Methodological validation of an existing telemetry system for QT evaluation in conscious guinea pigs

Journal of Pharmacological and Toxicological Methods

Volumn 55, Issue 1, 2007, Pages 27-34

  Shiotani, Motohiro ^a   Harada, Takuma ^a   Abe, Junko ^a   Hamada, Yoshimasa ^a   Horii, Ikuo ^a  

^a PFIZER INC   (United States)

Author keywords

ECG; Guinea pig; Methods; QT interval; Safety pharmacology; T wave; Telemetry system

Indexed keywords

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CALCULATION; DEVICE; ELECTROCARDIOGRAPHY; ELECTRODE; EVALUATION; GUINEA PIG; MALE; MATHEMATICAL ANALYSIS; NONHUMAN; QT INTERVAL; QT PROLONGATION; RELIABILITY; REPRODUCIBILITY; SCAPULA; STERNUM; T WAVE; TELEMETRY; VALIDATION PROCESS; WAVEFORM;

ANIMALS; ASTEMIZOLE; ELECTROCARDIOGRAPHY; ELECTRODES, IMPLANTED; GUINEA PIGS; LONG QT SYNDROME; MALE; MODELS, ANIMAL; SOTALOL; TELEMETRY;

ANIMALIA; CAVIA;

EID: 33845996505     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2006.04.008     Document Type: Article

References (22)

1. Akita M., Ishii K., Kuwahara M., and Tsubone H. The daily pattern of heart rate, body temperature, and locomotor activity in guinea pigs. Experimental Animals 50 (2001) 409-415
2. Bazett H.C. An analysis of the time-relations of electrocardiograms. Heart 7 (1920) 353-370
3. De Clerck F., van de Water A., D'Aubioul J., Lu H.R., van Rossem K., Hermans A., et al. In vivo measurement of QT prolongation, dispersion and arrhythmogenesis: Application to the preclinical cardiovascular safety pharmacology of a new chemical entity. Fundamental and Clinical Pharmacology 16 (2002) 125-140
4. Farkas A., Batey A.J., and Coker S.J. How to measure electrocardiographic QT interval in the anaesthetized rabbit. Journal of Pharmacological and Toxicological Methods 50 (2004) 175-185
5. Fridericia L.S. Die systolendauer im elektrokardiogramm bei normaln Menschen und bei Herzkranken. Acta Medica Scandinavica 53 (1920) 469-486
6. 1-antihistamines in a guinea-pig model of arrhythmogenicity. British Journal of Pharmacology 119 (1996) 187-188
7. Hamlin R.L., Kijtawornrat A., Keene B.W., and Hamlin D.M. QT and RR intervals in conscious and anesthetized guinea pigs with highly varying RR intervals and given QTc-lengthening test articles. Toxicological Sciences 76 (2003) 437-442
8. Harada T., Abe J., Shiotani M., Hamada Y., and Horii I. Effect of autonomic nervous function on QT interval in dogs. Journal of Toxicological Sciences 30 (2005) 229-237
9. Harada T., Shiotani M., Abe J., and Hamada Y. Usefulness of measuring QT interval in beagle dogs with chest lead. Advances in Animal Cardiology 37 (2004) 8-13
10. Hassimoto M., Harada T., Kaga N., Murano H., and Obata M. Accurate evaluation of QT interval in conscious rhesus monkeys (Macaca mulatta) by use of Holter ECG. Journal of Electrocardiology 35 (2002) 333-342
11. Hill S.L., Evangelista J.K., Pizzi A.M., Mobassaleh M., Fulton D.R., and Berul C.I. Proarrhythmia associated with cisapride in children. Pediatrics 101 (1998) 1053-1056
12. Horii I., Kito G., Hamada T., Jikuzono T., Kobayashi K., and Hashimoto K. Development of telemetry system in the common marmoset - cardiovascular effects of astemizole and nicardipine. Journal of Toxicological Sciences 27 (2002) 123-130
13. Kawataki M., Kashima T., Toda H., and Tanaka H. Relation between QT interval and heart rate. Applications and limitations of Bazett's formula. Journal of Electrocardiology 17 (1984) 371-375
14. Kramer K., Kinter L., Brockway B.P., Voss H.P., Remie R., and van Zutphen B.L. The use of radiotelemetry in small laboratory animals: Recent advances. Contemporary topics in laboratory animal science/American Association for Laboratory Animal Science 40 (2001) 8-16
15. Kulmatycki K.M., Abouchehade K., Sattari S., and Jamali F. Drug-disease interactions: Reduced beta-adrenergic and potassium channel antagonist activities of sotalol in the presence of acute and chronic inflammatory conditions in the rat. British Journal of Pharmacology 133 (2001) 286-294
16. Kurumiya S., and Kawamura H. Circadian oscillation of the multiple unit activity in the guinea pig suprachiasmatic nucleus. Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology 162 (1988) 301-308
17. Lindstrom E., Farde L., Eberhard J., and Haverkamp W. QTc interval prolongation and antipsychotic drug treatments: Focus on sertindole. International Journal of Neuropsychopharmacology/Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 8 (2005) 615-629
18. Matsunaga T., Mitsui T., Harada T., Inokuma M., Murano H., and Shibutani Y. QT corrected for heart rate and relation between QT and RR intervals in beagle dogs. Journal of Pharmacological and Toxicological Methods 38 (1997) 201-209
19. Nahas K., and Geffray B. QT interval measurement in the dog: Chest leads versus limb leads. Journal of Pharmacological and Toxicological Methods 50 (2004) 201-207
20. Noda Y., and Hashimoto K. Development of a halothane-adrenaline arrhythmia model using in vivo guinea pigs. Journal of Pharmacological Sciences 95 (2004) 234-239
21. Ohmura T., Chachin M., Tarui S., Nagakura A., Igarashi T., Ikeda H., et al. Effects of terfenadine, astemizole and epinastine on electrocardiogram in conscious cynomolgus monkeys. European Journal of Pharmacology 378 (1999) 169-175
22. Tobler I., Franken P., and Jaggi K. Vigilance states, EEG spectra, and cortical temperature in the guinea pig. American Journal of Physiology 264 (1993) 1125-1132