The role of ketoconazole in the QTc interval prolonging effects of H1-antihistamines in a guinea-pig model of arrhythmogenicity

British Journal of Pharmacology

Volumn 119, Issue 2, 1996, Pages 187-188

  Gras, J ^a   Llenas, J ^a   Palacios, J M ^a   Roberts, D J ^a  

^a Centro de Investigación y Desarrollo   (Spain)

Author keywords

Ebastine; Ketoconazole; Loratadine; QTc interval; Terfenadine

Indexed keywords

EBASTINE; HISTAMINE H1 RECEPTOR ANTAGONIST; KETOCONAZOLE; LORATADINE; TERFENADINE;

ANIMAL EXPERIMENT; ARRHYTHMOGENESIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ELECTROCARDIOGRAM; GUINEA PIG; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; QT INTERVAL; TELEMETRY;

EID: 0029818606     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15968.x     Document Type: Article

References (8)

1. CRUMB, W.J., WIBLE, B., ARNOLD, D.J., PAYNE, J.P. & BROWN, A.M. (1994). Blockade of multiple human cardiac potassium currents by the antihistamine terfenadine: possible mechanism of action of terfenadine-associated cardiotoxicity. Mol. Pharmacol., 47, 181-190.
2. HEEL, R.C. (1982). Toxicology and safety studies in Ketoconazole in the Management of Fungal Disease. ed. Levine, H.B. pp. 74-76. New York: ADIS Press.
3. HEY, J., DEL PRADO, M., KREUTNER, W. & EGAN, R.W. (1996). Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes. Arzneim. Forsch., 46, 159-163.
4. HONIG, P.K., WORTHAM, D.C., ZAMANI, K., CONNER, D.P., MULLIN, J.C. & CANTILENA, L.R. (1993). Terfenadine-ketoconazole interaction. JAMA, 269, 1513-1518.
5. MATHEWS, J.N.S., ALTMAN, D.G., CAMPBELL, M.J. & ROYSTON, P. (1989). Analysis of serial measurements in medical research. Br. Med. J., 300, 230-235.
6. MONAHAN, B.P., FERGUSON, C.L., KILLEAVY, E.S., LLOYD, B.K., TROY, J. & CANTILENA, L.R. (1990). Torsades de pointes occurring in association with terfenadine use. JAMA. 264, 2788-2790.
7. NIGHTINGALE, S.L. (1992). Warnings issued on nonsedating antihistamines terfenadine and astemizole. JAMA. 266, 705.
8. + channel cloned from human heart. Mol. Pharmacol., 44, 1240-1245.