Anti-inflammatory activity of the synthetic C-C biflavonoids

Journal of Pharmacy and Pharmacology

Volumn 58, Issue 12, 2006, Pages 1661-1667

  Park, Haeil ^a   Kim, Young Hoon ^a   Chang, Hyeun Wook ^b   Kim, Hyun Pyo ^a  

^a Kangwon National University   (South Korea)

^b Yeungnam University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5,6 DIHYDRO 6 METHYL 4H 1,3 THIAZINE; BIFLAVONOID; CARRAGEENAN; CYCLOOXYGENASE 2; ENZYME INHIBITOR; GINKGETIN; LIPOPOLYSACCHARIDE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN E2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PAW EDEMA; PROSTAGLANDIN SYNTHESIS INHIBITION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIFLAVONOIDS; BLOTTING, WESTERN; CARRAGEENAN; CELL LINE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MOLECULAR STRUCTURE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITROBENZENES; PREDNISOLONE; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SULFONAMIDES;

EID: 33845986353     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.58.12.0014     Document Type: Article

References (20)

1. Amella, M., Bronner, F., Hagg, M., Anton, R., Landry, Y. (1985) Inhibition of mast cell histamine release by flavonoids and biflavonoids. Planta Med. 16-20
2. Banerjee, T., Valacchi, G., Ziboh, V. A., van der Vliet, A. (2002) Inhibition of TNF-α-induced cyclooxygenase-2 expression by amentoflavone through suppression of NF-κB activation in A549 cells. Mol. Cell. Biochem. 238: 105-110
3. 2 by naturally occurring biflavonoid, ochnaflavone. Biochem. Biophys. Res. Comm. 205: 843-849
4. 2 inhibitory biflavonoids. Bioorg. Med. Chem. Lett. 16: 2373-2375
5. Cheon, B. S., Kim, Y. H., Son, K. H., Chang, H. W., Kang, S. S., Kim, H. P. (2000) Effects of prenylated flavonoids and biflavonoids on lipopolysaccharide-induced nitric oxide production from the mouse macrophage cell line RAW 264.7. Planta Med. 66: 596-600
6. Chi, Y. S., Cheon, B. S., Kim, H. P. (2001) Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells. Biochem. Pharmacol. 61: 1195-1203
7. Chi, Y. S., Lim, H., Park, H., Kim, H. P. (2003) Effect of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. Biochem. Pharmacol. 66: 1271-1278
8. Gabor, M. (1986) Anti-inflammatory and antiallergic properties of flavonoids. In: Cody, V., Middleton, E., Harborne, J. B. (eds) Plant flavonoids in biology and medicine: Biochemical, pharmacological, and structure-activity relationships. Alan R. Liss, New York, pp 471-480
9. 2 with anti-inflammatory activity. Biochem. Pharmacol. 53: 733-740
10. Iwu, M. M., Igboko, O. A., Okunji, C. O., Tempesta, M. S. (1990) Antidiabetic and aldose reductase activity of biflavanones of Garcinia kola. J. Pharm. Pharmacol. 42: 290-292
11. Kim, H. P., Son, K. H., Chang, H. W., Kang, S. S. (2004) Anti-inflammatory plant flavonoids and cellular action mechanisms. J. Pharmacol. Sci. 96: 229-245
12. Kwak, W.-J., Han, C. K., Son, K. H., Chang, H. W., Kang, S. S., Park, B. K., Kim, H. P. (2002) Effects of Ginkgetin from Ginkgo biloba leaves on cyclooxygenases and in vivo skin inflammation. Planta Med. 68: 316-321
13. Lee, S. J., Choi, S. H., Son, K. H., Chang, H. W., Kang, S. S., Kim, H. P. (1995) Suppression of mouse lymphocyte proliferation in vitro by naturally-occurring biflavonoids. Life Sci. 57: 551-558
14. Lin, Y.-M., Flavin, M. T., Cassidy, C. S., Mar, A., Chen, F.-C. (2001) Biflavonoids as novel antituberculosis agents. Bioorg. Med. Chem. Lett. 11: 2101-2104
15. Middleton, E., Kandaswami, C., Theoharides, T. C. (2000) The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol. Rev. 52: 673-751
16. Mossman, T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays. J. Immunol. Methods 65: 55-63
17. Murakami, M., Kudo, I. (2004) Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway. Prog. Lipid Res. 43: 3-35
18. Ruckstuhl, M., Berez, A., Anton, R., Landry, Y. (1979) Flavonoids are selective cyclic phosphodiesterase inhibitors. Biochem. Pharmacol. 28:535-538
19. Selvam, C., Jachak, S. M. (2004) A cyclooxygenase (COX) inhibitory biflavonoid from the seeds of Semecarpus anacardium. J. Ethnopharmacol. 95: 209-212
20. Winter, C. A., Risley, E. A., Nuss, G. W. (1962) Carrageenan-induced edema in the hindpaw of the rat as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. Med. 111: 544-547