Effects of sodium hyaluronate and methylprednisolone acetate on proteoglycan metabolism in equine articular chondrocytes treated with interleukin-1

American Journal of Veterinary Research

Volumn 67, Issue 12, 2006, Pages 1980-1986

  Yates, Angela C ^a   Stewart, Allison A ^a   Bryon, Christopher R ^a   Pondenis, Holly C ^a   Kaufmann, Karissa M ^a   Constable, Peter D ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; DNA; GLYCOSAMINOGLYCAN; HYALURONIC ACID; INTERLEUKIN 1; MESSENGER RNA; METHYLPREDNISOLONE ACETATE; PROTEOGLYCAN; SODIUM SULFATE; SULFUR 35;

ANIMAL CELL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARTILAGE CELL; CELL CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; DNA CONTENT; DRUG POTENTIATION; GENE EXPRESSION; HORSE; INFLAMMATION; MONOTHERAPY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEOGLYCAN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; CHONDROCYTES; HORSES; HYALURONIC ACID; INFLAMMATION; INTERLEUKIN-1; METHYLPREDNISOLONE; PROTEOGLYCANS; SULFUR RADIOISOTOPES;

EQUIDAE;

EID: 33845969889     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.67.12.1980     Document Type: Article

References (33)

1. American Horse Council Web site. Deloitte Consulting LLP for the American Horse Council Foundation in 2005. Available at: www.horsecouncil.org Accessed Oct 31, 2005.
2. Jeffcott LB, Rossdale PD, Freestone J. An assessment of wastage in Thoroughbred racing from conception to 4 years of age. Equine Vet J 1982;14:185-198.
3. Pool RP, Meagher DM. Pathologic findings and pathogenesis of racetrack injuries. Vet Clin North Am Equine Pract 1990;4;6:1-30.
4. Rossdale PD, Hopes R, Digby NJ, et al. Epidemiological study of wastage among racehorses 1982 and 1983. Vet Rec 1985;116:66-69.
5. Dyson S. Lameness and poor performance in the sports horse: dressage, show jumping and horse trials (eventing), in Proceedings. 46th Annu Meet Am Assoc Equine Pract 2000;46:308-315.
6. Frisbie DD. Effects of 6α-methylprednisolone acetate on an equine osteochondral fragment exercise model. Am J Vet Res 1998;59:1619-1628.
7. Roneus B, Lindblad A, Lindholm A, et al. Effects of intraarticular corticosteroid and sodium hyaluronate injections on synovial fluid production and synovial fluid content of sodium hyaluronate and proteoglycans in normal equine joints. Zentralbl Veterinarmed [A] 1993;401:10-16.
8. Rydell NW, Butler J, Balazs EA. Hyaluronic acid in synovial fluid. VI. Effect of intra-articular injection of hyaluronic acid on the clinical symptoms of arthritis in track horses. Acta Vet Scand 1970;11:139-155.
9. Meagher DM. The effects of intra-articular corticosteroids and continued training on carpal chip fractures of horses, in Proceedings. 25th Annu Meet Am Assoc Equine Pract 1979;405-412.
10. Karakok M, Ugras S, Tosun N, et al. Effect of intra-articular administration of hyaluronan and cortisone on secondary osteoarthritis of the infected rabbit's knee. Tohoku J Exp Med 2001;1951:35-42.
11. Foland JW, McIllwraith CW, Trotter GW, et al. Effects of betamethasone and exercise on equine carpal joints with osteochondral fragments. Vet Surg 1994;23:369-376.
12. Frisbie DD, Kawcak CE, Trotter GW, et al. Effects of triamcinolone acetonide on an in vivo equine osteochondral fragment exercise model. Am J Vet Res 1997;29:349-359.
13. Chunekamarai S, Krook LP, Lust G, et al. Changes in articular cartilage after intra-articular injections of methylprednisilone acetate in horses. Am J Vet Res 1989;50:1733-1741.
14. Murphy DJ, Todhunter RJ, Fubini SL, et al. The effects of methylprednisolone on normal and monocyte-conditioned medium-treated articular cartilage from dogs and horses. Vet Surg 2000;29:546-575.
15. Doyle AJ, Stewart AA, Constable PE, et al. Effects of sodium hyaluronate and methylprednisolone acetate on proteoglycan synthesis in equine articular cartilage explants. Am J Vet Res 2005;66:48-53.
16. Knudson CB. Hyaluronan receptor-directed assembly of chondrocyte pericellular matrix. J Cell Biol 1993;1203:825-834.
17. Nishida Y. Antisense inhibition of hyaluronan synthase-2 in human articular chondrocytes inhibits proteoglycan retention and matrix assembly. J Biol Chem 1999;274:21893-21899.
18. Sztrolovics R, Recklies AD, Roughley PJ, et al. Hyaluronate degradation as an alternative mechanism for proteoglycan release from cartilage during interleukin-1beta-stimulated catabolism. Biochem J 2002;362:473-479.
19. Fukuda K, Dan H, Takayama M, et al. Hyaluronic acid increases proteoglycan synthesis in bovine articular cartilage in the presence of interleukin-1. J Pharmacol Exp Ther 1996;277:1672-1676.
20. Homandberg GA, Hui F, Wen C, et al. Hyaluronic acid suppresses fibronectin fragment mediated cartilage chondrolysis: I. In vitro. Osteoarthritis Cartilage 1997;5:309-319.
21. Morris EA, Wilcon S, Treadwell BV. Inhibition of interleukin 1-mediated proteoglycan degradation in bovine articular cartilage explants by the addition of sodium hyaluronate. Am J Vet Res 1992;53:1977-1982.
22. Ghosh P, Guidolin D. Potential mechanism of action of intra-articular hyaluronan therapy in osteoarthritis: are the effects molecular weight dependent? Semin Arthritis Rheum 2002;18:10-37.
23. Masuda K, Shirota H, Thonar E. Quantification of 35S-labeled proteoglycans complexed to alcian blue by rapid filtration in multiwell plates. Anal Biochem 1994;217:167-175.
24. Farndale RW, Sayers CA, Barrett AJ. A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures. Connect Tissue Res 1982;9:247-248.
25. Kim YJ, Sah RL, Doong JY, et al. Fluorometric assay of DNA in cartilage explants using Hoechst 33258. Anal Biochem 1988;174:168-176.
26. Stewart MC, Kadlcek RM, Robbins PD, et al. Expression and activity of the CDK inhibitor p57Kip2 in chondrocytes undergoing hypertrophic differentiation. J Bone Miner Res 2004;19:123-133.
27. -cT method. Methods 2001;25:402-408.
28. Axelrod L. Glucocorticoids. In: Harris ED, Kelley WN, Ruddy S, et al, eds. Textbook of rheumatology. 4th ed. Philadelphia: WB Saunders Co, 1993;779-796.
29. Trotter GW. Intra-articular corticosteroids. In: McIllwraith CW, Trotter GW, eds. Joint disease in the horse. Philadelphia: WB Saunders Co, 1996;237-256.
30. Rae MT, Niven D, Critchley HO, et al. Antiinflammatory steroid action in human ovarian surface epithelial cells. J Clin Endocrinol Metab 2004;89:4538-4544.
31. Dechant JE, Baxter GM, Frisbie DD, et al. Effect of dosage titration of methylprednisolone acetate and triamcinolone acetonide on interleukin-1-conditioned equine articular cartilage explants in vitro. Equine Vet J 2003;35:444-450.
32. Abe M, Takahashi M, Nagano A. The effect hyaluronic acid with different molecular weights on collagen crosslink synthesis in cultured chondrocytes embedded in collagen gels. J Biomed Mater Res A 2005;75:494-496.
33. Atamaz F, Kirazli Y, Akkoc Y. A comparison of two different intra-articular hyaluronan drugs and physical therapy in the management of knee osteoarthritis. Rheumatol Int 2006;26:873-878.