Investigation of major genetic polymorphisms in the renin-angiotensin- aldosterone system in subjects with young-onset hypertension selected by a targeted-screening system at university

Clinical and Experimental Hypertension

Volumn 29, Issue 1, 2007, Pages 61-67

  Miyama, Noriyuki ^a   Hasegawa, Yoko ^b   Suzuki, Michiko ^a   Hida, Wataru ^b   Kazama, Itsuro ^a   Hatano, Ryo ^a   Sanada, Satoru ^a   Arata, Tomoaki ^a   Michimata, Mari ^a   Sato, Akira ^a   Satomi, Susumu ^a   Matsubara, Mitsunobu ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Angiotensin converting enzyme; Casual blood pressure; Essential hypertension; Home blood pressure; White coat hypertension

Indexed keywords

ALDOSTERONE SYNTHASE; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSINOGEN; DIPEPTIDYL CARBOXYPEPTIDASE;

ADULT; CONFERENCE PAPER; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ESSENTIAL HYPERTENSION; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC SCREENING; GENOTYPE; HUMAN; HYPERTENSION; JAPANESE; MALE; MEDICAL EXAMINATION; ONSET AGE; POPULATION GENETICS; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; STUDENT; SYSTOLIC BLOOD PRESSURE; WHITE COAT HYPERTENSION;

ADOLESCENT; ADULT; AGE OF ONSET; ALDOSTERONE SYNTHASE; ALLELES; ANGIOTENSINOGEN; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD PRESSURE; FEMALE; GENETIC SCREENING; GENOTYPE; HUMANS; HYPERTENSION; JAPAN; MALE; PEPTIDYL-DIPEPTIDASE A; POLYMORPHISM, GENETIC; RECEPTOR, ANGIOTENSIN, TYPE 1; RENIN-ANGIOTENSIN SYSTEM;

EID: 33845959394     PISSN: 10641963     EISSN: 15256006     Source Type: Journal    
DOI: 10.1080/10641960601096968     Document Type: Conference Paper

References (17)

1. Matsubara M. Genetic determination of human essential hypertension. Tohoku J. Exp. Med. 2000;192:19-33.
2. Matsubara M. Renal sodium handling for body fluid maintenance and blood pressure regulation. Yakugaku Zasshi 2004;124:301-309.
3. Ishikawa K, Baba S, Katsuya T, Iwai N, Asai T, Fukuda M, Takiuchi S, Fu Y, Mannami T, Ogata J, Higaki J, Ogihara T. T + 31C polymorphism of angiotensinogen gene and essential hypertension. Hypertension 2001;37:281-285.
4. Higaki J, Baba S, Katsuya T, Sato N, Ishikawa K, Manami T, Ogata J, Ogihara T. Deletion allele of angiotensin-converting enzyme gene increase risk of essential hypertension in Japanese men. The Suita Study. Circulation 1998;101:2060-2065.
5. Takami S, Katsuya T, Rakugi H, Sato N, Nakata Y, Kamitani A, Miki T, Higaki J, Ogihara T. Angiotensin II type 1 receptor gene polymorphism is associated with increased left ventricular mass but not with hypertension. Am J Hypertens 1998;11:316-321.
6. Tsujita Y, Iwai N, Katsuya T, Higaki J, Ogihara T, Takami S, Kinoshita M, Mannami T, Ogata J, Baba S. Lack of association between genetic polymorphism of CYP11B2 and hypertension in Japanese: the Suita Study. Hypertens Res 2001;24:105-109.
7. Matsubara M, Metoki H, Katsuya T, Kikuya M, Suzuki M, Michimata M, Araki T, Tsuji I, Ogihara T, Imai Y. T + 31C polymorphisms (M235T) of the angiotensinogen gene and home blood pressure in the Japanese general population: the Ohasama study. Hypertens Res 2003;26:47-52.
8. Matsubara M, Suzuki M, Fujiwara T, Kikuya M, Metoki H, Michimata M, Araki T, Kazama I, Sato T, Hozawa A, Ohkubo T, Tsuji I, Katsuya T, Higaki J, Ogihara T, Satoh H, Imai Y. Angiotensin converting enzyme I/D polymorphism and hypertension: the Ohasama study. J Hypertens 2002;20:1121-1126.
9. 1166 gene polymorphism of the angiotensin II type 1 receptor (AT1) and ambulatory blood pressure: the Ohasama Study. Hypertens Res 2003;26:141-145.
10. Matsubara M, Kikuya M, Ohkubo T, Metoki H, Fujiwara T, Suzuki M, Hozawa A, Katsuya T, Higaki J, Tsuji I, Araki T, Ogihara T, Satoh S, Hisamichi S, Nagai K, Kitaoka H, Imai Y. Aldosterone synthase gene (CYP11B2) C-344T polymorphism; ambulatory blood pressure and nocturnal decline in blood pressure in the general Japanese population: the Ohasama study. J Hypertens 2001;19:2179-2184.
11. Matsubara M, Sato T, Nishimura T, Suzuki M, Kikuya M, Metoki H, Michimata M, Tsuji I, Ogihara T, Imai Y. CYP11B2 polymorphisms and home blood pressure in a population-based cohort in Japanese: the Ohasama Study. Hypertens Res 2004;27:1-6.
12. Lifton RP, Dluhy RG, Powers M, Rich GM, Cook S, Ulick S, Lalouel J-M. A chimaeric 11β-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature 1992;355:262-265.
13. Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, Gill Jr JR, Ulick S, Milora RV, Findling JW, Canessa CM, Rossier BC, Lifton RP. Liddle's syndrome: heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel. Cell 1994;79:407-414.
14. Mune T, Rogerson FM, Nikkila H, Agarwal AK, White PC. Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase. Nat Genet 1995;10:394-399.
15. Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP. Human hypertension caused by mutations in WNK kinases. Science 2001;293:1107-1112.
16. O'Donnell CJ, Lindpaintner K, Larson MG, Rao VS, Ordovas JM, Schaefer EJ, Myers RH, Levy D. Evidence for association and genetic linkage of the angiotensin converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham heart study. Circulation 1998;97:1766-1772.
17. Bonnardeaux A, Davies E, Jeunemaitre X, Fery I, Charru A, Clauser E, Tiret L, Cambien F, Corvol P, Soubrier F. Angiotensin II type 1 receptor gene polymorphism in human essential hypertension. Hypertension 1994;24:63-69.