Challenges and opportunities in abdominal aortic aneurysm research

Journal of Vascular Surgery

Volumn 45, Issue 1, 2007, Pages 192-198

  Wassef, Momtaz ^a   Upchurch Jr , Gilbert R ^b   Kuivaniemi, Helena ^c   Thompson, Robert W ^d   Tilson III, M D ^e  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Departments of Surgery   (United States)

^e ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; ATENOLOL; COLLAGEN; DOXYCYCLINE; ELASTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOSARTAN; MATRIX METALLOPROTEINASE INHIBITOR; PROSTAGLANDIN SYNTHASE INHIBITOR; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ABDOMINAL AORTA ANEURYSM; AGE DISTRIBUTION; ANEURYSM RUPTURE; AORTA DISSECTION; ARTICLE; ATHEROSCLEROSIS; AUTOSOMAL DOMINANT INHERITANCE; BIOMECHANICS; CIGARETTE SMOKING; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; GENE LOCUS; GENE MAPPING; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HEREDITY; HISTOPATHOLOGY; HUMAN; HYPERTENSION; INCIDENCE; MARFAN SYNDROME; NON INVASIVE PROCEDURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SEX DIFFERENCE; TENSILE STRENGTH; THORACIC AORTA ANEURYSM;

ANIMALS; AORTIC ANEURYSM, ABDOMINAL; BIOMEDICAL RESEARCH; HUMANS; INCIDENCE; RISK FACTORS; VASCULAR SURGICAL PROCEDURES;

EID: 33845953683     PISSN: 07415214     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jvs.2006.09.004     Document Type: Article

References (46)

1. Thompson R.W., Geraghty P.J., and Lee J.K. Abdominal aortic aneurysms: basic mechanisms and clinical implications. Curr Probl Surg 39 (2002) 93-232
2. Wassef M., Baxter B.T., Chisholm R.L., et al. Pathogenesis of abdominal aortic aneurysms: a multidisciplinary research program supported by the National Heart, Lung, and Blood Institute. J Vasc Surg 34 (2001) 730-738
3. Alcorn H.G., Wolfson Jr. S.K., Sutton-Tyrrell K., et al. Risk factors for abdominal aortic aneurysms in older adults enrolled in The Cardiovascular Health Study. Arterioscler Thromb Vasc Biol 16 (1996) 963-970
4. Reed D., Reed C., Stemmermann G., and Hayashi T. Are aortic aneurysms caused by atherosclerosis?. Circulation 85 (1992) 205-211
5. Tilson M.D. Aortic aneurysms and atherosclerosis. Circulation 85 (1992) 378-379
6. Beere P.A., Glagov S., and Zarins C.K. Experimental atherosclerosis at the carotid bifurcation of the cynomolgus monkey-localization, compensatory enlargement, and the sparing effect of lowered heart rate. Arteriosler Thromb 12 (1992) 1245-1253
7. Longo G.M., Xiong W., Greiner T.C., et al. Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms. J Clin Invest 110 (2002) 625-632
8. Pyo R., Lee J.K., Shipley J.M., et al. Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J Clin Invest 105 (2000) 1641-1649
9. Daugherty A., Manning M.W., and Cassis L.A. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest 105 (2000) 1605-1612
10. Deng G.G., Martin-McNulty B., Sukovich D.A., et al. Urokinase-type plasminogen activator plays a critical role in angiotensin II-induced abdominal aortic aneurysm. Circ Res 92 (2003) 510-517
11. Silence J., Lupu F., Collen D., and Lijnen H.R. Persistence of atherosclerotic plaque but reduced aneurysm formation in mice with stromelysin-1 (MMP3) gene inactivation. Arterioscler Thromb Vasc Biol 21 (2001) 1440-1445
12. Silence J., Collen D., and Lijnen H.R. Reduced atherosclerotic plaque but enhanced aneurysm formation in mice with inactivation of the tissue inhibitor of metalloproteinase-1 (TIMP-1) gene. Circ Res 90 (2002) 897-903
13. Guo D., Hasham S., Kuang S.Q., et al. Familial thoracic aortic aneurysms and dissections: genetic heterogeneity with a major locus mapping to 5q13-14. Circulation 103 (2001) 2461-2468
14. Vaughan C.J., Casey M., He J., et al. Identification of a chromosome 11q23.2-q24 locus for familial aortic aneurysm disease, a genetically heterogeneous disorder. Circulation 103 (2001) 2469-2475
15. Kuivaniemi H., Shibamura H., Arthur C., et al. Familial abdominal aortic aneurysms: collection of 233 multiplex families. J Vasc Surg 37 (2003) 340-345
16. Verloes A., Sakalihasan N., Koulischer L., and Limet R. Aneurysms of the abdominal aorta: familial and genetic aspects in three hundred thirteen pedigrees. J Vasc Surg 21 (1995) 646-655
17. Majumder P.P., St Jean P.L., Ferrell R.E., Webster M.W., and Steed D.L. On the inheritance of abdominal aortic aneurysm. Am J Hum Genet 48 (1991) 164-170
18. Shibamura H., Olson J.M., van Vlijmen-Van Keulen C., et al. Genome scan for familial abdominal aortic aneurysm using sex and family history as covariates suggests genetic heterogeneity and identifies linkage to chromosome 19q13. Circulation 109 (2004) 2103-2108
19. Neptune E.R., Frischmeyer P.A., Arking D.E., et al. Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome. Nat Genet 33 (2003) 407-411
20. Habashi J.P., Judge D.P., Holm T.M., et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 312 (2006) 36-37
21. Crawford E.S., and Cohen E.S. Aortic aneurysm: a multifocal disease. Arch Surg 117 (1982) 1393-1400
22. Wolinsky H., and Glagov S. A lamellar unit of aortic medial structure and function in mammals. Circ Res 20 (1967) 99-111
23. Allaire E., Forough R., Clowes M., Starcher B., and Clowes A.W. Local overexpression of TIMP1 prevents aortic aneurysm degeneration and rupture in a rat model. J Clin Invest 102 (1998) 1413-1420
24. Shi G.P., Sukhova G.K., Grubb A., et al. Cystatin C deficiency in human atherosclerosis and aortic aneurysms. J Clin Invest 104 (1999) 1191-1197
25. Koch A.E., Haines G.K., Rizzo R.J., et al. Human abdominal aortic aneurysms. Immunophenotypic analysis suggesting an immune-mediated response. Am J Pathol 137 (1990) 1199-1213
26. Gregory A.K., Yin N.X., Capella J., et al. Features of autoimmunity in the abdominal aortic aneurysm. Arch Surg 131 (1996) 85-88
27. Schonbeck U., Sukhova G.K., Gerdes N., and Libby P. T(H)2 predominant immune responses prevail in human abdominal aortic aneurysm. Am J Pathol 161 (2002) 499-506
28. Pereira L., Lee S.Y., Gayraud B., et al. Pathogenetic sequence for aneurysm revealed in mice underexpressing fibrillin-1. Proc Natl Acad Sci U S A 96 (1999) 3819-3823
29. Pereira L., Andrikopoulos K., Tian J., et al. Targeting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome. Nat Genet 17 (1997) 218-222
30. Segura A.M., Luna R.E., Horiba K., et al. Immunohistochemistry of matrix metalloproteinases and their inhibitors in thoracic aortic aneurysms and aortic valves of patients with Marfan's syndrome. Circulation 98 19 Suppl (1998) II331-II337
31. Curci J.A., Mao D., Bohner D.G., et al. Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patients with abdominal aortic aneurysms. J Vasc Surg 31 (2000) 325-342
32. Mosorin M., Juvonen J., Biancari F., et al. Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: a randomized, double-blind, placebo-controlled pilot study. J Vasc Surg 34 (2001) 606-610
33. Baxter B.T., Pearce W.H., Waltke E.A., et al. Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: report of a prospective (phase II) multicenter study. J Vasc Surg 36 (2002) 1-12
34. Goldberg I.D., Stemerman M.B., Ransil B.J., and Fuhro R.L. In vivo aortic muscle cell growth kinetics. Differences between thoracic and abdominal segments after intimal injury in the rabbit. Circ Res 47 (1980) 182-189
35. Baxter B.T., Davis V.A., Minion D.J., Wang Y.P., Lynch T.G., and McManus B.M. Abdominal aortic aneurysms are associated with altered matrix proteins of the nonaneurysmal aortic segments. J Vasc Surg 19 (1994) 797-802
36. Chew D.K., Knoetgen III J., Xia S., Gaetz H.P., and Tilson M.D. Regional distribution in human of a novel aortic collagen-associated microfibrillar protein. Exp Mol Pathol 66 (1999) 59-65
37. Schachter D., and Sang J.C. Regional differentiation in the rat aorta: effects of cyclooxygenase inhibitors. Am J Physiol 273 3 Pt 2 (1997) H1478-H1483
38. Ikonomidis J.S., Gibson W.C., Gardner J., et al. A murine model of thoracic aortic aneurysms. J Surg Res 115 (2003) 157-163
39. Raghavan M.L., Vorp D.A., Federle M.P., Makaroun M.S., and Webster M.W. Wall stress distribution on three-dimensionally reconstructed models of human abdominal aortic aneurysm. J Vasc Surg 31 (2000) 760-769
40. Fillinger M.F., Raghavan M.L., Marra S.P., Cronenwett J.L., and Kennedy F.E. In vivo analysis of mechanical wall stress and abdominal aortic aneurysm rupture risk. J Vasc Surg 36 (2002) 589-597
41. Fillinger M.F., Marra S.P., Raghavan M.L., and Kennedy F.E. Prediction of rupture risk in abdominal aortic aneurysm during observation: wall stress versus diameter. J Vasc Surg 37 (2003) 724-732
42. Kent K.C., Zwolak R.M., Jaff M.R., et al. Screening for abdominal aortic aneurysm: a consensus statement. J Vasc Surg 39 (2004) 267-269
43. Brown L.C., and Powell J.T. Risk factors for aneurysm rupture in patients kept under ultrasound surveillance. UK Small Aneurysm Trial Participants. Ann Surg 230 (1999) 289-296
44. Lederle F.A., Johnson G.R., Wilson S.E., et al. Rupture rate of large abdominal aortic aneurysms in patients refusing or unfit for elective repair. JAMA 287 (2002) 2968-2972
45. Lederle F.A., Wilson S.E., Johnson G.R., et al. Immediate repair compared with surveillance of small abdominal aortic aneurysms. N Engl J Med 346 (2002) 1437-1444
46. Wever J.J., Blankensteijn J.D., Th M Mali W.P., and Eikelboom B.C. Maximal aneurysm diameter follow-up is inadequate after endovascular abdominal aortic aneurysm repair. Eur J Vasc Endovasc Surg 20 (2000) 177-182