Human lysosomal DNase IIα contains two requisite PLD-signature (HxK) motifs: Evidence for a pseudodimeric structure of the active enzyme species

Protein Science

Volumn 16, Issue 1, 2007, Pages 82-91

  Schäfer, Patrick ^a   Cymerman, Iwona A ^b   Bujnicki, Janusz M ^b   Meiss, Gregor ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Poland)

Author keywords

Active site; Apoptosis; DNA fragmentation; DNase; Phospholipase D; Structure

Indexed keywords

DNA FRAGMENT; LYSOSOMAL DNASE 2ALPHA; LYSOSOME ENZYME; PHOSPHOLIPASE D; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL ANALYSIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN MOTIF; PROTEIN STRUCTURE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CATALYTIC DOMAIN; ENDODEOXYRIBONUCLEASES; HUMANS; LYSOSOMES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EUKARYOTA; MAMMALIA;

EID: 33845952655     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.062535307     Document Type: Article

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