Therapeutic and neuroprotective efficacy of pharmacological pretreatment and antidotal treatment of acute tabun or soman poisoning with the emphasis on pretreatment drug PANPAL

Arhiv za Higijenu Rada i Toksikologiju

Volumn 57, Issue 4, 2006, Pages 427-434

  Kassa, Jiři ^a,b  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Acetylcholinesterase reactivators; Anticholinergic drugs; Functional observatory battery; Mice; Pyridostigmine; Rats

Indexed keywords

ANTIDOTE; ATROPINE; BENACTYZINE; DIAZEPAM; OBIDOXIME; OXIME DERIVATIVE; PYRIDOSTIGMINE; SOMAN; TABUN; TRIHEXYPHENIDYL;

ARMY; BLOOD BRAIN BARRIER; CZECH REPUBLIC; DRUG EFFICACY; INTOXICATION; LD 50; NEUROPROTECTION; NONHUMAN; PROPHYLAXIS; PROVOCATION TEST; REVIEW; SPECTROPHOTOMETRY;

ANIMALS; ANTIDOTES; BENACTYZINE; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; DRUG COMBINATIONS; NEUROPROTECTIVE AGENTS; PHOSPHORIC ACID ESTERS; PYRIDOSTIGMINE BROMIDE; SOMAN; TRIHEXYPHENIDYL;

EID: 33845947238     PISSN: 00041254     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (33)

1. Kassa J. Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents. J Toxicol Clin Toxicol 2002;40:803-16.
2. Marrs TC. Organophosphate poisoning. Pharmacol Ther 1993;58:51-66.
3. th ed. New York (NY): McGraw Hill; 1996. p. 161-76.
4. Cabal J, Bajgar J. Tabun - návrat po 50 letech [Tabun: Reappearance following 50 years, in Czech]. Chem Listy 1999;93:27-31.
5. Eto M. Organophosphorus Pesticides: Organic and Biological Chemistry. Cleveland: CRC Press Inc; 1976.
6. Koplovitz I, Menton R, Matthew C, Shutz M, Nalls C, Kelly S. Dose-response effects of atropine and HI-6 treatment of organophosphorus poisoning in guinea pigs. Drug Chem Toxicol 1995;18:119-36.
7. Dawson RM. Review of oximes available for treatment of nerve agent poisoning. J Appl Toxicol 1994;14:317-31.
8. Bajgar J. Organophosphates/nerve agents poisonings: mechanism of action, diagnosis, prophylaxis, and treatment. Adv Clin Chem 2004;38:155-216.
9. Anderson DR, Harris LW, Woodard CL, Lennox WI. The effect of pyridostigmine pretreatment on oxime efficacy against intoxication by soman or VX in rats. Drug Chem Toxicol 1992;15:285-92.
10. Bajgar J, Fusek J, Vachek J. Treatment and prophylaxis against nerve agent poisoning. ASA Newsletter 1994;94:10-11.
11. Kassa J, Bajgar J. The influence of pharmacological pretreatment on efficacy of HI-6 oxime in combination with benactyzine in soman poisoning in rats. Hum Exp Toxicol 1996;15:383-8.
12. Kassa J, Fusek J. The positive influence of a cholinergic-anticholinergic pretreatment and antidotal treatment on rats poisoned with supralethal doses of soman. Toxicology 1998;128:1-7.
13. Vachek J, Kassa J, Fusek J, Bajgar J. Novější způsoby léčby intoxikace organofosfáty [The present possibilities of the treatment of poisonings with organophosphates, in Czech]. Sbor věd Prací VLA JEP Hradec Krâlové 1993;116:67-95.
14. Bajgar J. Prophylaxis against organophosphorus poisonings. J Med Chem Def 2003. Available at 〈 http://www.jmedchemdef.org 〉.
15. Fusek J, Bajgar J, Vachek J. The prophylactic antidote against nerve paralytic agents - PANPAL. Proceedings of the Meeting of NATO TG 004 Task Group on Prophylaxis and Therapy of Chemical Agents; 2-5 October 2000; The Hague, The Netherlands. Rijswijk: TNO Prins Maurits Laboratory; 2000. p. 63-4.
16. Tallarida R, Murray R. Manual of Pharmacological Calculation with Computer Programs. New York (NY): Springer-Verlag; 1987.
17. Ellman GL, Courtney DK, Andres VJr, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961;7:88-95.
18. Kassa J, Vachek J. A combination of the efficacy of pyridostigmine alone and the combination of pyridostigmine with anticholinergic drugs as pharmacological pretreatment of tabun-poisoned rats and mice. Toxicology 2002;177:179-85.
19. Kassa J, Vachek J, Bajgar J, Fusek J. A combination of pyridostigmine with anticholinergic drugs: effective pharmacological pretreatment of soman-poisoned mice. ASA Newslett 2001;01-3:16-9.
20. Kassa J, Vachek J, Bajgar J, Fusek J. A combination of the efficacy of pharmacological pretreatments against soman in mice. Voj zdrav Listy 2001;70 Suppl. 1:22-5.
21. Kassa J, Cabal J, Bajgar J, Szinicz L. The choice: HI-6, pralidoxime or obidoxime against nerve agents? ASA Newslett 1997;97-4:16-8.
22. Koplovitz I, Harris LW, Anderson DR, Lennox WJ, Steward JR. Reduction by pyridostigmine pretreatment of the efficacy of atropine and 2-PAM treatment of tabun, sarin and VX poisoning in rodents. Fundam Appl Toxicol 1992;18:102-6.
23. Koplovitz I, Stewart JR. A comparison of the efficacy of HI-6 and 2-PAM against soman, tabun, sarin and VX in the rabbit. Toxicol Lett 1994;70:269-79.
24. Frantik E, Hornychova M. Clustering of neurobehavioral measures of toxicity. Homeostasis 1995;36:19-25.
25. Hornychova M, Frantik E, Kubat J, Formanek J. Neurotoxicity profile of supermethrin, a new pyrethroid insekticide. Cent Eur J Publ Health 1995;3:210-8.
26. Moser VC, Tilson H, McPhail RC, Becking QC, Cuomo V, Frantik E, Kulig GM, Winneke G. The IPCS collaborative study on neurobehavioral screening methods: II. Protocol design and testing procedures. Neuro Toxicology 1997;18:929-38.
27. Roth Z, Josifko M, Maly V, Trcka V. Statistical Methods in Experimental Medicine. Prague: SZN Czechoslovakia; 1962.
28. Krejcova G, Kassa J. Neuroprotective efficacy of pharmacological pretreatment and antidotal treatment in tabun-poisoned rats. Toxicology 2003;185:129-39.
29. Koupilová M, Kassa J. The influence of Panpal pretreatment on the elimination of soman-induced neurotoxicity by antidotes in rats. Homeostasis 1999;39:133-5.
30. Gouge SF, Daniels DJ, Smith CE. Exacerbation of asthma after pyridostigmine during Operation Desert Storm. Mil Med 1994;159:108-13.
31. Wenger B, Quigley MD, Kokla MA. Seven-day pyridostigmine administration and thermoregulation during rest and exercise in dry heat. Aviat Space Environ Med 1993;64:905-12.
32. Abou-Donia MB, Goldstein LB, Jones KH, Abdel-Rahman AA, Damodaran TV, Dechkovskaia AM, Bullman SL, Amir BE, Khan WA. Locomotor and sensorimotor performance deficit in rats following exposure to pyridostigmine bromide, DEET, and permethrin, alone and in combination. Toxicol Sci 2001;60:305-10.
33. Clement JG, Shiloff JD, Gennings C. Efficacy of a combination of acetylcholinesterase reactivators, HI-6 and obidoxime, against tabun and soman poisoning in mice. Arch Toxicol 1987;61:70-5.