hTERT mRNA expression is associated with a poor clinical outcome in human breast cancer

Anticancer Research

Volumn 26, Issue 6 C, 2006, Pages 4901-4904

  Elkak, A ^a   Mokbel, R ^a   Wilson, C ^b   Jiang, W G ^c   Newbold, R F ^b   Mokbel, Kefah ^a,b  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b BRUNEL UNIVERSITY   (United Kingdom)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Breast cancer; hTERT mRNA; Prognosis; Survival; Telomerase

Indexed keywords

MESSENGER RNA; TELOMERASE REVERSE TRANSCRIPTASE;

ARTICLE; BREAST CANCER; CANCER GRADING; CANCER MORTALITY; CANCER SURVIVAL; CANCER TISSUE; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RATING SCALE; RECURRENT CANCER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; STATISTICAL SIGNIFICANCE;

BREAST NEOPLASMS; DISEASE-FREE SURVIVAL; HUMANS; NEOPLASM STAGING; RNA, MESSENGER; TELOMERASE; TREATMENT OUTCOME;

EID: 33845943560     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Morin GB: The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesises TTAGGG repeats. Cell 59: 521-529, 1989.
2. Harley CB: Telomere loss: Mitotic clock or genetic time bomb? Mutation Res 256: 271-282, 1991.
3. Kim NW, Piatyszek MA, Prowse KR et al: Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015, 1994.
4. Rhyu MS: Telomeres, Telomeres and immortality. J Na Cancer Inst 87: 884-894, 1995.
5. Chadeneau C, Hay K, Hirte H W et al: Telomerase activity associated with acquisition of malignancy in human colorectal cancer. Cancer Res 55: 2533-2536, 1995.
6. Blackburn EH: Structure and formation of telomeres. Nature 550: 569-573, 1991.
7. Hiyama E, Gollahon L, Kataoka TE et al: Telomerase activity in human breast tumours. J Natl Cancer Inst 88: 116-122, 1996.
8. Hiyama E, Yokoyama T, Tatsumoto N et al: Telomerase activity in gastric cancer. Cancer Res 55: 3258-3262, 1995.
9. Feng J, Funk WD, Wang SS et al: The RNA component of human telomerase. Science 269: 1236-1241, 1995.
10. Harrington L, McPhail T, Mar V et al: A mammalian telomerase-associated protein. Science 275: 973-977, 1997.
11. Yang H, Kyo S, Takatura M et al: Autocrine transformation growth factor b suppresses telomerase activity and transcription of human telomerase reverse transcriptase in human cancer cells. Cell Growth Differ 12: 119-127, 2001.
12. Nakamura TM, Morin GB, Chapman KB et al: Telomerase catalytic subunit homologs from fission yeast and human. Science 277: 955-959, 1997.
13. Weinrich SL, Pruzan R, Ma L et al: Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTERT. Nat Genet 17: 498-502, 1997.
14. Kirkpatrick KL and Mokbel K: The significance of human telomerase reverse transcriptase (hTERT) in cancer. Eur J Surg Oncol 127: 754-760, 2001.
15. Nakayama J, Tahara H, Tahara E et al: Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat Genet 18: 65-68, 1998.
16. Meyerson M, Counter CM, Eaton EN et al: hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90: 785-795, 1997.
17. Kirkpatrick KL, Ogunkolade W, Elkak AE, Bustin S, Jenkins P, Ghilchick M and Mokbel K: hTERT expression in human breast cancer and non-cancerous breast tissue: correlation with tumour stage and c-Myc expression. Breast Cancer Res Treat 77: 277-284, 2003.
18. Jiang WG, Watkins G, Lane J, Douglas-Jones A, Cunnick GH, Mokbel M and Mansel RE: Prognostic value of Rho familty and and rho-GDIs in breast cancer. Clin. Cancer Res 9: 6432-6440, 2003.
19. Elkak AE, Meligonis G, Salhab M, Mitchell B, Blake JR, Newbold RF and Mokbel K: hTERT protein expression is independent of clinicopathological parameters and c-Myc protein expression in human breast cancer. J Carcinog 4: 17, 2005.
20. Mokbel K, Ghilchik M, Williams G et al: The association between telomerase activity and hormone receptor status and p53 expression in breast cancer. IJ Surg Invest 1: 509-516, 2000.
21. Clark G, Osborne CK, Levitt D et al: Telomerase activity and survival of patients with node-positive breast cancer. J Natl Cancer Inst 89: 1874-1881, 1997.
22. Roos G, Nilsson P, Cajander S et al: Telomerase activity in relation to p53 status and clinico-pathological parameters in breast cancer. Int J Cancer 79: 343-348, 1998.
23. Poremba C, Heine B, Diallo R et al: Telomerase as a prognostic marker in breast cancer: high-throughput tissue microarray analysis of hTERT and hTR. J Path 198: 181-189, 2002.