Cytogenetic and molecular studies of an unusual case of multiple primary alveolar rhabdomyosarcomas: Low-level chromosomal instability and reciprocal translocation t(6;11)

Experimental and Molecular Pathology

Volumn 82, Issue 1, 2007, Pages 58-62

  Wang, Zhiqin ^a   Velagaleti, Gopalrao V N ^a   Eltorky, Mahmoud A ^a   Tang, Wendell W ^a   Hawkins, Hal K ^a   Jones, Elizabeth A ^a   Northup, Jill ^a   Panova, Neli ^a   Qiu, Suimin ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Alveolar rhabdomyosarcoma; Chromosomal instability; Chromosomal translocation; Mirror image tumor; t(6; 11)

Indexed keywords

PROTEIN P53; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR PAX3; TRANSCRIPTION FACTOR PAX7;

ARTICLE; CASE REPORT; CHROMOSOMAL INSTABILITY; CHROMOSOME 6; CYTOGENETICS; DNA SEQUENCE; EXON; FUSION GENE; GENE FUSION; GENE MUTATION; GERM LINE; HUMAN; MALE; ONSET AGE; POLYMERASE CHAIN REACTION; RECIPROCAL CHROMOSOME TRANSLOCATION; RHABDOMYOSARCOMA; SCHOOL CHILD;

CHEEK; CHILD; CHROMOSOMAL INSTABILITY; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 6; FOREARM; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; MALE; NEOPLASMS, MULTIPLE PRIMARY; RHABDOMYOSARCOMA, ALVEOLAR; TRANSLOCATION, GENETIC;

EID: 33845941743     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2006.09.004     Document Type: Article

References (13)

1. Barr F.G., Qualman S.J., Macris M.H., Melnyk N., Lawlor E.R., Strzelecki D.M., Triche T.J., Bridge J.A., and Sorensen P.H. Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusions. Cancer Res. 62 (2002) 4704-4710
2. Barr F.G., Smith L.M., Lynch J.C., Strzelecki D., Parham D.M., Qualman S.J., and Breitfeld P.P. Examination of gene fusion status in archival samples of alveolar rhabdomyosarcoma entered on the intergroup rhabdomyosarcoma study-III trial: a report from the children's oncology group. J. Mol. Diagn. 8 (2006) 202-208
3. Blann M., Velagaleti G.V.N., Morgan D.L., Martinez R.E., Conlin P.A., and Tonk V.S. Interstitial deletion of 20q in a patient with Waldenstrom macroglobulinemia following chemotherapy. Cancer Genet. Cytogenet. 132 (2002) 145-148
4. Burds A.A., Lutum A.S., and Sorger P.K. Generating chromosome instability through the simultaneous deletion of Mad2 and p53. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 11296-11301
5. Gatalica G., Velagaleti G., Kuivaniemi H., Tromp G., Palazzo J., Graves K.M., Guigneaux M., Wood T., Sinha M., and Luxon B. Gene expression profile of an adenomyoepithelioma of the breast with a reciprocal translocation involving chromosome 8 and 16. Cancer Genet. Cytogenet. 156 (2005) 14-22
6. Herzog C.E., Stewart J.M., and Blakely M.L. Pediatric soft tissue sarcomas. Surg. Oncol. Clin. N. Am. 12 (2003) 419-447
7. Merlino G., and Helman L.J. Rhabdomyosarcoma-Working out the pathways. Oncogene 18 (1999) 5340-5348
8. Middel P., Gunawan B., Gross A.J., Radzun H.J., and Fuzesi L. Chromosome abnormalities in a primary adult embryonal rhabdomyosarcoma of the prostate. Histopathology 37 (2000) 378-380
9. Nowak M.A., Komarova N.L., Sengupta A., Jallepalli P.V., Shih I.M., Vogelstein B., and Lengauer C. The role of chromosomal instability in tumor initiation. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 16226-16231
10. Pearson P. The use of new staining techniques for human chromosome identification. J. Med. Genet. 9 (1972) 264-275
11. Varley J.M. Germline TP53 mutations and Li-Fraumeni syndrome. Hum. Mutat. 21 (2003) 313-320
12. Welborn J.L., Jenks H.M., and Hagemeijer A. Unique clinical features and prognostic significance of the translocation (6;11) in acute leukemia. Cancer Genet. Cytogenet. 65 (1993) 125-129
13. Wong K.F., Chan J.K., and Sin V.C. T-cell prolymphocytic leukemia with a novel translocation (6;11)(q21;q23). Cancer Genet. Cytogenet. 111 (1999) 149-151