Stability of insulin under iontophoretic conditions

Pharmazie

Volumn 61, Issue 12, 2006, Pages 1014-1018

  Panchagnula, Ramesh ^a,b   Bindra, P ^a   Kumar, N ^a   Shanker Dey, C ^a   Pillai, O ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

ARTICLE; BIOASSAY; BIOLOGICAL ACTIVITY; DEGRADATION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONTOPHORESIS; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; RADIOIMMUNOASSAY;

ADMINISTRATION, CUTANEOUS; ANIMALS; BLOOD GLUCOSE; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIABETES MELLITUS, EXPERIMENTAL; DIFFUSION CHAMBERS, CULTURE; ELECTROCHEMISTRY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; HYDROGEN-ION CONCENTRATION; HYPOGLYCEMIC AGENTS; INSULIN; IONTOPHORESIS; KINETICS; RADIOIMMUNOASSAY; RATS; RATS, SPRAGUE-DAWLEY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 33845927195     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Banga AK, Chien YW (1993) Characterization of in vitro transdermal iontophoretic delivery of insulin. Drug Dev Ind Pharm 19: 2069-2087.
2. Banga AK, Reddy IK (1994) Biotechnology drugs: Pharmaceutical issues. Pharmacy Times 60: 68-76.
3. Brange J, Langkjaer L (1993) Insulin structure and stability, in: Wang YJ, Pearlman R (ed.) Stability and characterization of protein and peptide drugs, Plenum Press, pp. 315-345.
4. Brange J, Langkjaer L, Havelund S, Volund A (1992) Chemical stability of insulin. 1. hydrolytic degradation during storage of pharmaceutical preparations. Pharm Res 9: 715-726.
5. Chiang CH, Shao CH, Chen JL (1988) Effect of pH, electric current, and enzyme inhibitors on iontophoresis of delta sleep-inducing peptide. Drug Dev Ind Pharm 24: 431-438.
6. Huang YY, Wu SM (1996) Stability of peptides during iontophoretic transdermal delivery. Int J Pharm 131: 19-23.
7. Kari B (1986) Control of blood glucose in alloxan-diabetic rats by iontophoresis of insulin. Diabetes 35: 217-221.
8. Meril CR, Goldman D, Sedman SA, Ebert MH (1981) Ultra sensitive stain for proteins in polyacrylamide gels shows regional variation in cerebrospinal fluid proteins. Science 211: 1437-1438
9. Pillai O, Nair V, Poduri R, Panchagnula R (1999) Transdermal iontophoresis. Part II: Peptide and protein delivery. Methods Find Exp Clin Pharmacol 21: 229-240.
10. Pillai O, Nair V, Jain AK, Thomas NS, Panchagnula R (2001) Noninvasive transdermal delivery of peptides and proteins. Drugs Future 26: 779-791.
11. Pillai O, Kumar N, Dey CS, Borkute S, Nagalingam S, Panchagnula R (2003a) Transdermal iontophoresis of insulin. Part I: A study on the issues associated with the use of platinum electrodes on rat skin. J Pharm Pharmacol 55: 1505-1513.
12. Pillai O, Borkute SD, Sivaprasad N, Panchagnula R (2003b) Transdermal iontophoresis of insulin. II: Physicochemical considerations. Int J Pharm 254: 271-280.
13. Pillai O, Panchagnula R (2003c) Transdermal delivery of insulin from poloxamer gel: Ex vivo and in vivo skin permeation studies in rat using iontophoresis and chemical enhancers. J Control Release 89: 127-140.
14. Rivier J, McClintock R (1983) Reversed-phase high performance liquid chromatography of insulins from different species. J Chromatogr 268: 112-119.