On the mechanism of an asymmetric α,β-unsaturated carboxylic acid hydrogenation: Application to the synthesis of a PGD2 receptor antagonist

Journal of the American Chemical Society

Volumn 128, Issue 51, 2006, Pages 17063-17073

  Tellers, David M ^a   McWilliams, J Christopher ^a   Humphrey, Guy ^a   Journet, Michel ^a   DiMichele, Lisa ^a   Hinksmon, Joseph ^a   McKeown, Arlene E ^a   Rosner, Thorsten ^a   Sun, Yongkui ^a   Tillyer, Richard D ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASYMMETRIC HYDROGENATION CATALYSTS; CHIRAL LIGANDS; LOW HYDROGEN PRESSURES; RUTHENIUM COMPLEXES;

CARBOXYLIC ACIDS; CATALYSTS; DEUTERIUM COMPOUNDS; HYDROGENATION; MOLECULAR STRUCTURE; SYNTHESIS (CHEMICAL);

RUTHENIUM COMPOUNDS;

2,2' BIS(DIPHENYLPHOSPHINO) 1,1' BINAPHTHYL DERIVATIVE; PROSTAGLANDIN D2 RECEPTOR ANTAGONIST; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; RUTHENIUM DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ASYMMETRIC SYNTHESIS; CARBON METABOLISM; CATALYST; CHIRALITY; COMPLEX FORMATION; DRUG SYNTHESIS; ENANTIOMER; HYDROGENATION; HYDROGENOLYSIS; LIGAND BINDING; METAL BINDING; PHOTOCHEMISTRY; REDUCTION KINETICS;

ALKENES; CARBOXYLIC ACIDS; DEUTERIUM; HYDROGEN; HYDROGENATION; KINETICS; MOLECULAR STRUCTURE; PRESSURE; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; STEREOISOMERISM; TEMPERATURE;

EID: 33845920911     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0623358     Document Type: Article

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