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Volumn 43, Issue 25, 2004, Pages 3224-3228

Asymmetric catalysis in the pharmaceutical industry

Author keywords

Asymmetric catalysis; Chiral auxiliaries; Freedom to operate; Hydrogenation; Industrial processes

Indexed keywords

CATALYSIS; HYDROGENATION; SYNTHESIS (CHEMICAL);

EID: 4544260095     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200330072     Document Type: Review
Times cited : (150)

References (27)
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    • For a detailed analysis illustrated with many examples including the use of enzymes, see reference [2].
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    • Note
    • In favorable cases, the benefits of continuous chromatography outweigh the capital expense for specialty equipment, which can be operated internally or at a specialist company.
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    • For other multistep routes to sertraline tetralone (S)-1 by using asymmetric catalysis, see: E. J. Corey, T. G. Gant, Tetrahedron Lett. 1994, 35, 5373; M. Lautens, T. Rovis, J. Org. Chem. 1997, 62, 5246; H. M. L. Davies, D. G. Stafford, T. Hansen, Org. Lett. 1999, 1, 233.
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    • For other multistep routes to sertraline tetralone (S)-1 by using asymmetric catalysis, see: E. J. Corey, T. G. Gant, Tetrahedron Lett. 1994, 35, 5373; M. Lautens, T. Rovis, J. Org. Chem. 1997, 62, 5246; H. M. L. Davies, D. G. Stafford, T. Hansen, Org. Lett. 1999, 1, 233.
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    • For other multistep routes to sertraline tetralone (S)-1 by using asymmetric catalysis, see: E. J. Corey, T. G. Gant, Tetrahedron Lett. 1994, 35, 5373; M. Lautens, T. Rovis, J. Org. Chem. 1997, 62, 5246; H. M. L. Davies, D. G. Stafford, T. Hansen, Org. Lett. 1999, 1, 233.
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    • Palladium prices from http://www.kitco.com/charts/historicalpalladium. html. We thank Dr. Don Zeng of Heraeus for pointing out this internet reference.
  • 27
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    • Note
    • Crystallization of the product of an asymmetric catalytic reaction, a step often included to enhance the optical purity, can contribute to the robustness of the process (for example, in the case of varying selectivity), provided that the optical purity does not drop below the eutectic composition.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.