Inclusion of the ASH1 gene that governs the neuroendocrine differentiation of lung epithelium as an additional prototypic 'lineage-survival oncogene' [1]

Nature Reviews Cancer

Volumn 7, Issue 1, 2007, Pages

  Osada, Hirotaka ^a   Takahashi, Takashi ^b  

^a AICHI CANCER CENTER HOSPITAL   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; RNA; VIRUS LARGE T ANTIGEN;

ACHAETE SCUTE HOMOLOGUE 1 GENE; APOPTOSIS; CANCER INHIBITION; CARCINOGENESIS; CELL CYCLE ARREST; CELL DIFFERENTIATION; CELL LINEAGE; CELL SURVIVAL; CELLULAR DISTRIBUTION; GENE FUNCTION; GENE REPRESSION; GENE TARGETING; LETTER; LUNG ALVEOLUS EPITHELIUM; LUNG CARCINOGENESIS; NEUROSECRETORY CELL; ONCOGENE; PRIORITY JOURNAL; RNA INTERFERENCE; SIMIAN VIRUS 40; TRANSGENE; TUMOR GENE; TUMOR GROWTH;

EID: 33845887983     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc1947-c1     Document Type: Letter

References (7)

1. Garraway, L. A. & Sellers, W. R. Lineage dependency and lineage-survival oncogenes in human cancer. Nature Rev. Cancer 6, 593-602 (2006).
2. McGill, G. G. et al. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 109, 707-718 (2002).
3. Garraway, L. A. et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 436, 117-122 (2005).
4. Hong, K. U., Reynolds, S. D., Giangreco, A., Hurley, C. M. & Stripp, B. R. Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion. Am. J. Respir. Cell Mol. Biol. 24, 671-681 (2001).
5. Borges, M. et al. An achaete-scute homologue essential for neuroendocrine differentiation in the lung. Nature 386, 852-855 (1997).
6. Linnoila, R. I. et al. Constitutive achaete-scute homologue-1 promotes airway dysplasia and lung neuroendocrine tumors in transgenic mice. Cancer Res. 60, 4005-4009 (2000).
7. Osada, H., Tatematsu, Y., Yatabe, Y., Horio, Y. & Takahashi, T. ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features. Cancer Res. 65, 10680-10685 (2005).