Human Fanconi A cells are susceptible to TRAIL-induced apoptosis

British Journal of Haematology

Volumn 136, Issue 2, 2007, Pages 315-318

  Pigullo, Simona ^a   Ferretti, Elisa ^a   Lanciotti, Marina ^a   Bruschi, Maurizio ^a,b   Candiano, Giovanni ^a   Svahn, Johanna ^a   Haneline, Laura ^c   Dufour, Carlo ^a   Pistoia, Vito ^a   Corcione, Anna ^a  

^a G GASLINI INSTITUTE   (Italy)

^b Renal Child Foundation   (Italy)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Caspase 8; Fanconi type A cells; Poly(ADP ribose) polymerase 1 cleavage; Tumour necrosis factor related apoptosis inducing ligand

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; CASPASE 8; FANCONI ANEMIA GROUP A PROTEIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME ACTIVATION; FANCONI ANEMIA; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL LINE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; STRUCTURAL GENE; WESTERN BLOTTING;

APOPTOSIS; BIOLOGICAL MARKERS; CASPASE 8; CELL LINE, TUMOR; ENZYME ACTIVATION; FANCONI ANEMIA; FANCONI ANEMIA COMPLEMENTATION GROUP A PROTEIN; FANCONI ANEMIA COMPLEMENTATION GROUP C PROTEIN; HUMANS; OLIGOPEPTIDES; POLY(ADP-RIBOSE) POLYMERASES; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 33845874114     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2006.06432.x     Document Type: Article

References (12)

1. Chaudhary, P.M., Eby, M., Jasmin, A., Bookwalter, A., Murray, J. & Hood, L. (1997) Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. Immunity, 7, 821-830.
2. Clarke, A.A., Gibson, F.M., Scott, J., Myatt, N. & Rutherford, T.R. (2004) Fanconi's anemia cell lines show distinct mechanisms of cell death in response to mitomycin C or agonistic anti-Fas antibodies. Haematologica, 89, 11-20.
3. Degli-Esposti, M.A., Dougall, W.C., Smolak, P.J., Waugh, J.Y., Smith, C.A. & Goodwin, R.G. (1997a) The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity, 7, 813-820.
4. Degli-Esposti, M.A., Smolak, P.J., Walczak, H., Waugh, J., Huang, C.P., DuBose, R.F., Goodwin, R.G. & Smith, C.A. (1997b) Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. Journal of Experimental Medicine, 186, 1165-1170.
5. Dufour, C., Corcione, A., Svahn, J., Haupt, R., Poggi, V., Beka'ssy, A.N., Scime, R., Pistorio, A. & Pistoia, V. (2003) TNF-alpha and IFN-gamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro. Blood, 102, 2053-2059.
6. Faivre, L., Guardiola, P., Lewis, C., Dokal, I., Ebell, W., Zatterale, A., Altay, C., Poole, J., Stones, D., Kwee, M.L., van Weel-Sipman, M., Havenga, C., Morgan, N., de Winter, J., Digweed, M., Savoia, A., Pronk, J., de Ravel, T., Jansen, S., Joenje, H., Gluckman, E. & Mathew, C.G. (2000) Association of complementation group and mutation type with clinical outcome in Fanconi anemia. European Fanconi Anemia Research Group. Blood, 96, 4064-4070.
7. Haneline, L.S., Broxmeyer, H.E., Cooper, S., Hangoc, G., Carreau, M., Buchwald, M. & Clapp, D.W. (1998) Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac-/- mice. Blood, 91, 4092-4098.
8. Platzbecker, U., Kurre, P., Guardiola, P., Ward, J.L., Radich, J.P., Kiem, H.P. & Deeg, H.J. (2004) Fanconi anemia type C-deficient hematopoietic cells are resistant to TRAIL (TNF-related apoptosis-inducing ligand)-induced cleavage of pro-caspase-8. Experimental Hematology, 32, 815-821.
9. Rathbun, R.K., Christianson, T.A., Faulkner, G.R., Jones, G., Keeble, W., O'Dwyer, M. & Bagby, G.C. (2000) Interferon-gamma-induced apoptotic responses of Fanconi anemia group C hematopoietic progenitor cells involve caspase 8-dependent activation of caspase 3 family members. Blood, 96, 4204-4211.
10. Sheridan, J.P., Marsters, S.A., Pitti, R.M., Gurney, A., Skubatch, M., Baldwin, D., Ramakrishnan, L., Gray, C.L., Baker, K., Wood, W.I., Goddard, A.D., Godowski, P. & Ashkenazi, A. (1997) Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science, 277, 818-821.
11. Walczak, H., Degli-Esposti, M.A., Johnson, R.S., Smolak, P.J., Waugh, J.Y., Boiani, N., Timour, M.S., Gerhart, M.J., Schooley, K.A., Smith, C.A., Goodwin, R.G. & Rauch, C.T. (1997) TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO Journal, 16, 5386-5397.
12. Wiley, S.R., Schooley, K., Smolak, P.J., Din, W.S., Huang, C.P., Nicholl, J.K., Sutherland, G.R., Smith, T.D., Rauch, C., Smith, C.A. & Goodwin, R.G. (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity, 3, 673-682.