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Nilsson L, Kjellman NIM, Björkstén B. A randomized controlled trial of the effect of pertussis vaccines on atopic disease. Arch. Pediatr. Adolesc. Med. 152(8), 734-738 (1998). • A prospective study evaluating the effects of acellular and whole-cell pertussis vaccines. Results indicated a possible small increase in the risk of atopic disease after acellular pertussis vaccination at 2.5 years of age.
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Nilsson L, Kjellman NIM, Björkstén B. A randomized controlled trial of the effect of pertussis vaccines on atopic disease. Arch. Pediatr. Adolesc. Med. 152(8), 734-738 (1998). • A prospective study evaluating the effects of acellular and whole-cell pertussis vaccines. Results indicated a possible small increase in the risk of atopic disease after acellular pertussis vaccination at 2.5 years of age.
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Nilsson L, Kjellman NI, Bjorksten B. Allergic disease at the age of 7 years after pertussis vaccination in infancy: results from the follow-up of a randomized controlled trial of vaccines. Arch. Pediatr. Adolesc. Med. 157(12), 1184-1189 (2003). • A prospective study evaluating the effect of acellular and whole-cell pertussis vaccines at 7 years of age. There was no association between this vaccination (acellular or whole-cell) and the prevalence of asthma, allergic rhinoconjuntivitis, atopic dermatitis or any allergic disease at this age.
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Anderson HR, Poloniecki JD, Strachan DP, Beasley R, Björstén B, Asher MI, ISAAC Phase I study group. Immunization and symptoms of atopic disease in children: results from the International Study of Asthma and Allergies in Childhood. Am. J. Public Health 91(7), 1126-1129 (2001). •• Ecological study including more than 400,000 children that found an inverse relationship between the rates of diphtheria, tetanus and pertussis immunization and the prevalence of atopic diseases throughout the world.
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50
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DeStefano F, Gu D, Kramarz P et al. Vaccine safety datalink research group childhood vaccinations and risk of asthma. Pediatr. Infect. Dis. J. 21(6), 498-504 (2002). •• An extensive study in which a cohort of 167,000 children were followed: no differences on asthma prevalence among vaccinated and nonvaccinated children were found.
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Maher JE, Mullooly JP, Drew L, DeStefano F. Infant vaccinations and childhood asthma among full-term infants. Pharmacoepidemiol. Drug Saf. 13(1), 1-9 (2004). • A cohort study that reports that childhood asthma was not significantly associated with the number of doses of whole-cell pertussis vaccine and that the measles-mumps-rubella vaccine was not associated with an increase in the prevalence of asthma.
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Roost HP, Gassner M, Grize L et al. Influence of MMR-vaccinations and diseases on atopic sensitization and allergic symptoms in Swiss schoolchildren. Pediatr. Allergy Immunol. 15(5), 401-407 (2004). • Describes an inverse association between asthma and a positive disease history or vaccination against measles.
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Bager P, Westergaard T, Rostgaard K, Nielsen NM, Melbye M, Aaby P. Smallpox vaccination and risk of allergy and asthma. J. Allergy Clin. Immunol. 111(6), 1227-1231 (2003). • The only article reporting the relationship between smallpox vaccine and atopic disorders.
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Lewis SA, Britton JR. Measles infection, measles vaccination and the effect of birth order in the aetiology of hayfever. Clin. Exp. Allergy 28(12), 1493-1500 (1998). •• A study based on a British birth-cohort that explored the independent effect of measles infection and measles vaccination on the occurrence of hayfever. The authors concluded that in those children with contact with older siblings, hayfever was reduced significantly and independently in relation to both measles infection and measles vaccination, compared with those who were neither infected nor vaccinated.
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