Atypical onset of symptoms in Huntington disease: Severe cognitive decline preceding chorea or other motor manifestations

Cognitive and Behavioral Neurology

Volumn 19, Issue 4, 2006, Pages 222-224

  Cooper, Douglas B ^a   Ales, Gregory ^a   Lange, Christopher ^b   Clement, Pamelia ^a  

^a BROOKE ARMY MEDICAL CENTER   (United States)

^b CARL R DARNALL ARMY MEDICAL CENTER   (United States)

Author keywords

Cognitive dysfunction; Early clinical signs; Huntington disease

Indexed keywords

ADULT; ARTICLE; BRAIN ATROPHY; BRAIN DISEASE; CASE REPORT; CHOREA; CLINICAL EXAMINATION; CLINICAL FEATURE; COGNITIVE DEFECT; DIAGNOSTIC IMAGING; ELECTROENCEPHALOGRAM; GENETIC ANALYSIS; HUMAN; HUNTINGTON CHOREA; INFORMATION PROCESSING; MALE; MOTOR DYSFUNCTION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SYMPTOMATOLOGY;

ATROPHY; CEREBRAL CORTEX; COGNITION DISORDERS; DISEASE PROGRESSION; HUMANS; HUNTINGTON DISEASE; MALE;

EID: 33845793367     PISSN: 15433633     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.wnn.0000213917.10514.1e     Document Type: Article

References (25)

1. Squitieri F, Cannella M, Giallonardo P, et al. Onset and pre-onset studies to define the Huntington's disease natural history. Brain Res Bull. 2001;56:233-238.
2. Folstein SE, Leigh RJ, Parhad IM, et al. The diagnosis of Huntington's disease. Neurology. 1986;36:1279-1283.
3. Kirkwood SC, Su JL, Conneally PM, et al. Progression of symptoms in the early and middle stages on Huntington disease. Arch Neurol. 2001;58:273-278.
4. Brandt J, Shpritz B, Codori AM, et al. Neuropsychological manifestations of the genetic mutation for Huntington's disease in presymptomatic individuals. J Int Neuropsychol Soc. 2002;8:918-924.
5. de Boo GM, Tibben A, Lanser JB, et al. Early cognitive and motor symptoms in identified carriers of the gene for Huntington disease. Arch Neurol. 1997;54:1353-1357.
6. Witjes-Ane MW, Vegter-van der Vlis M, van Vugt JP, et al. Cognitive and motor functioning in gene carriers for Huntington's disease: a baseline study. J Neuropsychiatry Clin Neurosci. 2003;15:7-16.
7. Kirkwood SC, Siemers E, Hodes ME, et al. Subtle changes among presymptomatic carriers of the Huntington's disease gene. J Neurol Neurosurg Psychiatry. 2000;69:773-779.
8. Ho AK, Sahakian BJ, Brown RG, et al. Profile of cognitive progression in early Huntington's disease. Neurology. 2003;61:1702-1706.
9. Paulsen JS, Zhao H, Stout JC, et al. Clinical markers of early disease in persons near onset of Huntington's disease. Neurology. 2001;57:658-662.
10. Wilkinson GS. WRAT - 3: Administration Manual. Wilmington, DE: Wide Range, Inc; 1993.
11. Johnstone B, Wilhelm K. The longitudinal stability of the WRAT-R reading subtest: is it an appropriate estimate of premorbid intelligence? J Int Neuropsychol Soc. 1996;2:282-285.
12. Beck AT, Steer RA. Beck Depression Inventory: Manual. San Antonio, TX: Psychological Corporation; 1993.
13. Wechsler D. Manual for the Wechsler Adult Intelligence Scale - Third Edition. San Antonio, TX: Psychological Corporation; 1993.
14. Reitan RM, Wolfson D. The Halstead-Reitan Neuropsychological Test Battery: Theory and Clinical Interpretation. Tucson, AZ: Neuropsychology Press; 1993.
15. Heaton RK, Grant I, Matthews CG. Comprehensive Norms for an Expanded Halstead-Reitan Battery. Lutz, FL: Psychological Assessment Resources, Inc; 1991.
16. Heaton RK. Wisconsin Card Sorting Test: Revised Manual. Lutz, FL: Psychological Assessment Resources, Inc; 1999.
17. Delis DC, Kramer JH, Kaplan E, et al. California Verbal Learning Test - Second Edition: Manual. San Antonio, TX: Psychological Corporation; 2000.
18. Folstein MF, Folstein SE, McHugh PR. Mini Mental State: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189-198.
19. Huntington Study Group. Unified Huntington's disease rating scale: reliability and consistency. Movement Disord. 1996;11:136-142.
20. Almquist EW, Elterman DS, MacLeod PM, et al. High incidence rate and absent family histories in one quarter of patients newly diagnosed with Huntington disease in British Columbia. Clin Genet. 2001;60:198-205.
21. Glosser G. Neurobehavioral aspects of movement disorders. Neurol Clin. 2001;19:535-551.
22. Aylward EH, Codori AM, Rosenblatt A, et al. Rate of caudate atrophy in presymptomatic and symptomatic stages of Huntington's disease. Movement Disord. 2000;15:552-560.
23. Aylward EH, Anderson NB, Bylsma FW, et al. Frontal lobe volume in patients with Huntington's disease. Neurology. 1998;50:252-258.
24. Roos RAC. Neuropathology of Huntington's chorea. In: Vinken PJ, Bruyn GW, Klawans HL, eds. Handbook of Clinical Neurology. Vol. 5: Extrapyramidal Disorders. Amsterdam: Elsevier Science Publishers; 1986:315-326.
25. Rasmusson DX, Brandt J, Martin DB, et al. Head injury as a risk factor for Alzheimer's disease. Brain Injury. 1995;9:213-219.