Possibilities and limitations of fluorescence in situ hybridization technique in retrospective detection of low dose radiation exposure in post-Chernobyl human cohorts

Cytology and Genetics

Volumn 39, Issue 4, 2005, Pages 25-31

  Maznyk, N A ^a   Vinnikov, V A ^a  

^a Institute of Medical Radiology   (Ukraine)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CHERNOBYL ACCIDENT; COHORT ANALYSIS; ENVIRONMENTAL EXPOSURE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE TRANSLOCATION; HUMAN; LYMPHOCYTE; MIDDLE AGED; POLLUTANT; RADIATION EXPOSURE; RADIATION RESPONSE; REPRODUCIBILITY; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; TIME; UKRAINE;

ADOLESCENT; ADULT; CHERNOBYL NUCLEAR ACCIDENT; COHORT STUDIES; DOSE-RESPONSE RELATIONSHIP, RADIATION; ENVIRONMENTAL EXPOSURE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOCYTES; MIDDLE AGED; RADIOACTIVE POLLUTANTS; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; TIME FACTORS; TRANSLOCATION, GENETIC; UKRAINE;

EID: 33845781939     PISSN: 05643783     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Cytogenetic analysis for radiation dose assessment. A manual // IAEA Technical Report Series No 405. - Vienna: IAEA, 2001. - 127 p.
2. 60Co gamma ray dose-response for chromosomal aberrations in human lymphocytes analysed by FISH; applicability to biological dosimetry // Int. J. Radiat. Biol. - 1999. - 75, No 10. - P. 1215-1222.
3. Maznyk N.A., Vinnikov V.A. Calibration dose-response relationships for cytogenetic biodosimetry of recent and past exposure to low dose gamma-radiation // 2004. - 12, 4. - C. 415-425.
4. Lucas J. N., Awa A., Straume T. et al. Rapid translocation frequency analysis in human decades after exposure to ionizing radiation // Int. J. Radiat. Biol. - 1992. - 62, No 1. - P. 53-63.
5. Sasaki M.S. Use of lymphocyte chromosome aberrations in biological dosimetry: possibilities and limitations // Radiation-induced chromosome damage in man / Eds T. Ishihara, M. Sasaki. - New York: A.R. Liss, 1983. - P. 585-604.
6. 137Cesium- induced chromosome aberrations analyzed by fluorescence in situ hybridization: eight years follow up of the Goiania radiation accident victims // Mutat. Res. - 1998. - 400. - P. 299-312.
7. Sevan'kaev A.V., Khvostunov I.K., Mikhailova G.F. et al. Novel data set for retrospective biodosimetry using both conventional and FISH chromosome analysis after high accidental overexposure // Appl. Radiat. Isot. - 2000. - 52. - P. 1149-1152.
8. Matsumoto K., Ramsey M. J., Nelson D. O., Tucker J. D. Persistence of radiation-induced translocations in human peripheral blood determined by chromosome painting // Radiat. Res. - 1998. - 149. - P. 602-613.
9. Gardner S.N., Tucker J.D. The cellular lethality of radiation-induced chromosome translocations in human lymphocytes // Radiat. Res. -2002. - 157. - P. 539-552.
10. Lindholm C., Edwards A. Long-term persistence of translocations in stable lymphocytes from victims of a radiological accident // Int. J. Radiat. Biol. - 2004. - 80, No 8. - P. 559-566.