Perinatal Brain Metabolism

Fetal and Neonatal Physiology: Third Edition

Volumn 2-2, Issue , 2003, Pages 1713-1725

  Vannucci, Robert C ^a   Vannucci, Susan J ^b  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b NEW YORK PRESBYTERIAN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33845775074     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-7216-9654-6.50171-5     Document Type: Chapter

References (129)

1. McIlwain H, Bachelard HS Biochemistry and the Central Nervous System 1971, Williams & Wilkins, Baltimore.
2. Siesjö BK Brain Energy Metabolism 1978, John Wiley & Sons, New York.
3. Hawkins R Cerebral energy metabolism. Cerebral Energy Metabolism and Metabolic Encephalopathy 1985, 3-23. Plenum Press, New York. D.W. McCandless (Ed.).
4. Lowry OH, et al. Effect of ischemia on known substrates and cofactors of the glycolytic pathway in brain. J Biol Chem 1964, 239:18.
5. Lehrer GM, et al. Enzymatic maturation of mouse cerebral neocortex in vitro and in situ. Exp Neurol 1970, 26:595.
6. Wilson JE The relationship between glycolytic and mitochondrial enzymes in the developing rat brain. J Biol Chem 1972, 239:223.
7. Cohen MM, Lim S Acid soluble phosphate in the developing rabbit brain. J Neurochem 1962, 9:345.
8. Mandel P, Edel-Harth S Free nucleotides in the rat brain during postnatal development. J Neurochem 1966, 13:591.
9. Thurston JH, McDougal DB Effect of ischemia on metabolism of the brain of the newborn mouse. Am J Physiol 1969, 216:348.
10. 31P NMR study of cerebral metabolism during prolonged seizures in the neonatal dog. Ann Neurol 1985, 18:14.
11. Gonya-Magee T, Vannucci RC Ontogeny of cerebral oxidative metabolism in the chick embryo. J Neurochem 1982, 38:1387.
12. Vannucci RC, Duffy TE The influence of birth on carbohydrate and energy metabolism in rat brain. Am J Physiol 1974, 226:933.
13. Duffy TE, Vannucci RC Perinatal brain metabolism: effects of anoxia and ischemia. Cerebral Vascular Disease 1975, 231-235. Grune & Stratton, New York. J.P. Whisnant, B.A. Sandok (Eds.).
14. Leonard JC, et al. Nuclear magnetic resonance: an overview of its spectroscopic and imaging applications in pediatric patients. J Pediatr 1985, 106:757.
15. Cady EB, et al. Non-invasive investigation of cerebral metabolism in newborn infants by phosphorus nuclear magnetic resonance spectroscopy. Lancet 1983, 1:1059.
16. Hamilton PA, et al. Impaired energy metabolism in brains of newborn infants with increased cerebral echodensities. Lancet 1986, 1:1242.
17. Younkin DP, et al. Unique aspects of human newborn cerebral metabolism evaluated with phosphorus nuclear magnetic resonance spectroscopy. Ann Neurol 1984, 16:581.
18. 31P magnetic resonance spectroscopy study in vivo. Pediatr Res 1994, 35:431.
19. 1H-magnetic resonance spectroscopy-determined cerebral lactate and poor neurologic outcomes in children with central nervous system disease. Ann Neurol 1997, 41:470.
20. Hanrahan JD, et al. Persistent increases in cerebral lactate concentration after birth asphyxia. Pediatr Res 1998, 44:304.
21. Barkovich AJ, et al. Proton MR spectroscopy for the evaluation of brain injury in asphyxiated, term neonates. AJNR Am J Neuroradiol 1999, 20:1399.
22. Himwich HE, et al. The respiratory metabolism of infant brain. Am J Physiol 1939, 125:601.
23. Himwich HE, et al. Mechanisms for the maintenance of life in the newborn during anoxia. Am J Physiol 1942, 135:387.
24. Tyler DB, van Harreveld A The respiration of the developing brain. Am J Physiol 1942, 136:600.
25. Swaiman KF, et al. Interrelationships of glucose and glutamic acid metabolism in developing rat brain. J Neurochem 1963, 10:635.
26. Himwich WA, et al. Metabolic studies on perinatal human brain. J Appl Physiol 1959, 14:873.
27. Himwich HE, Fazekas JF Comparative studies of the metabolism of brain of infant and adult dog. Am J Physiol 1941, 132:454.
28. Kjellmer I, et al. Cerebral reactions during intrauterine asphyxia in the sheep. I. Circulation and oxygen consumption in the fetal brain. Pediatr Res 1974, 8:50.
29. 2 metabolism after asphyxia in neonatal lambs. Pediatr Res 1986, 20:778.
30. 2-hemoglobin affinity in the regulation of cerebral blood flow in fetal sheep. Am J Physiol 1986, 251:H56.
31. 2 in fetal, newborn, and adult sheep. Am J Physiol 1982, 242:H862.
32. Brennan RW, et al. Cerebral blood flow and metabolism during cardiopulmonary bypass: evidence of microembolic encephalopathy. Neurology 1971, 21:665.
33. Hernandez MJ, et al. Cerebral blood flow and oxygen consumption in the newborn dog. Am J Physiol 1978, 234:R209.
34. Grubb RL, et al. Effects of increased intracranial pressure on cerebral blood volume, blood flow and oxygen utilization in monkeys. J Neurosurg 1975, 43:385.
35. Levitsky LL, et al. Fasting plasma levels of glucose, acetoacetate, d&-β-hydroxybutyrate, glycerol and lactate in the baboon infant: correlation with cerebral uptake of substrates and oxygen. Pediatr Res 1977, 11:298.
36. Garfunkel JM, et al. The relationship of oxygen consumption to cerebral functional activity. J Pediatr 1954, 44:64.
37. Kety SS, Schmidt CF The nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure, and normal values. J Clin Invest 1948, 27:476.
38. Settergren G, et al. Cerebral blood flow and exchange of oxygen, glucose, ketone bodies, lactate, pyruvate, and amino acids in anesthetized children. Acta Paediatr Scand 1980, 69:457.
39. Kennedy C, Sokoloff L An adaption of the nitrous oxide method to study the cerebral circulation in children, normal values for cerebral blood flow and cerebral metabolic rate. J Clin Invest 1957, 36:1130.
40. Wechsler RL, et al. Blood flow and oxygen consumption of the human brain during anesthesia produced by thiopental. Anesthesiology 1951, 12:308.
41. Altman DI, et al. Cerebral oxygen metabolism in newborns. Pediatrics 1993, 92:99.
42. Yoxall CW, Weindling AM Measurement of cerebral oxygen consumption in the human neonate using near infrared spectroscopy: cerebral oxygen consumption increases with advancing age. Pediatr Res 1998, 44:283.
43. Astrup J, et al. Inhibition of cerebral oxygen and glucose consumption in the dog by hypothermia, pentobarbital, and lidocaine. Anesthesiology 1981, 55:263.
44. Duffy TE, et al. Carbohydrate and energy metabolism in perinatal rat brain: relation to survival in anoxia. J Neurochem 1975, 24:271.
45. Swabb DF, Boer K The presence of biologically labile compounds during ischemia and their relationship to the EEG in rat cerebral cortex and hippothalamus. J Neurochem 1972, 19:2843.
46. Vannucci RC, Plum F Pathophysiology of perinatal hypoxic-ischemic brain damage. Biology of Brain Dysfunction 1975, Vol 3:1-45. Plenum Publishing, New York. G.E. Gaull (Ed.).
47. Murthy MRV, Rappoport DA Biochemistry of the developing rat brain. II. Neonatal mitochondrial oxidations. Biochim Biophys Acta 1963, 74:51.
48. Moore CL, Strasberg PM Mitochondrial oxidative metabolism. Handbook of Neurochemistry 1970, Vol 3:53-85. Plenum Press, New York. A. Lajtha (Ed.).
49. Holtzman D, Moore CL Oxidative phosphorylation in immature rat mitochondria. Biol Neonate 1973, 22:230.
50. Davison A, Dobbing J The developing brain. Applied Neurochemistry 1968, 253-286. Blackwell Scientific, Oxford. A. Davison, J. Dobbing (Eds.).
51. Samson FE, et al. Mitochondrial changes in developing rat brain. Am J Physiol 1960, 199:693.
52. Gjedde A, et al. Cerebral blood flow and oxygen consumption in rat, measured with microspheres or xenon. Acta Physiol Scand 1977, 100:273.
53. Mayman CI, Tijerina ML The effect of hypoglycemia on energy reserves of adult and newborn brain. Brain Hypoxia 1971, 242-249. JB Lippincott, Philadelphia. J.B. Brierley, B.S. Meldrum (Eds.).
54. Gregorie NM, et al. Cerebral blood flow and cerebral metabolic rates for oxygen, glucose, and ketone bodies in newborn dogs. J Neurochem 1978, 30:63.
55. Hernandez MJ, et al. Cerebral blood flow and metabolism during hypoglycemia in newborn dogs. J Neurochem 1980, 35:622.
56. Jones ME, et al. Cerebral metabolism in sheep: a comparative study of the adult, the lamb and the fetus. Am J Physiol 1975, 229:235.
57. Alexander SC, et al. Cerebral carbohydrate metabolism of man during respiratory and metabolic alkalosis. J Appl Physiol 1968, 24:66.
58. Kety SS Circulation and metabolism of the human brain in health and disease. Am J Med 1950, 8:205.
59. Sokoloff L Localization of functional activity in the central nervous system by measurement of glucose utilization with radioactive deoxyglucose. J Cereb Blood Flow Metab 1981, 1:7.
60. 14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure and normal values in the conscious and anesthetized albino rat. J Neurochem 1977, 28:897.
61. Abrams RM, et al. Local cerebral glucose utilization in fetal and neonatal sheep. Am J Physiol 1984, 246:R608.
62. Duffy TE, et al. Local cerebral glucose metabolism in newborn dogs: effects of hypoxia and halothane anesthesia. Ann Neurol 1982, 11:233.
63. Kennedy C Energy metabolism of the brain. Perinatal Brain Insult: Mead Johnson Symposium on Perinatal and Developmental Medicine #17 1981, 30-42. Mead Johnson and Company, Evansville, IL. J.C. Sinclair (Ed.).
64. Mujsce DJ, et al. Regional cerebral blood flow and glucose utilization during hypoglycemia in newborn dogs. Am J Physiol 1989, 256:H1659.
65. Vannucci RC, et al. Regional cerebral glucose utilization in the immature rat: effect of hypoxia-ischemia. Pediatr Res 1989, 26:208.
66. 18FDG positron emission tomography. Science 1986, 231:840.
67. Chugani HT, et al. Positron emission tomography study of human brain functional development. Ann Neurol 1987, 22:487.
68. Kinnala A, et al. Cerebral metabolic rate for glucose during the first six months of life: an FDG positron emission tomography study. Arch Dis Child 1996, 74:F153.
69. Powers WJ, et al. Cerebral glucose transport and metabolism in preterm human infants. J Cereb Blood Flow Metab 1998, 18:632.
70. Berntman L, et al. Cerebral oxygen consumption and blood flow in hypoxia: influence of sympathoadrenal activation. Stroke 1979, 10:20.
71. Dahlquist G, Persson B The rate of cerebral utilization of glucose, ketone bodies, and oxygen: a comparative in vivo study of infant and adult rats. Pediatr Res 1976, 10:910.
72. Forrester T, et al. Effect of adenosine trisphosphate and some derivatives on cerebral blood flow and metabolism. J Physiol 1979, 296:343.
73. Volpe JJ, et al. Positron emission tomography in the asphyxiated term newborn: parasagittal impairment of cerebral blood flow. Ann Neurol 1985, 17:287.
74. Cremer JE, Heath DF The estimation of rates of utilization of glucose and ketone bodies in the brain of the suckling rat using compartmental analysis of isotopic data. Biochem J 1974, 142:527.
75. Hawkins RA, et al. Ketone body utilization by adult and suckling rat brain in vivo. Biochem J 1971, 122:13.
76. Spitzer JJ, Weng JT Removal and utilization of ketone bodies by the brain of newborn puppies. J Neurochem 1972, 19:2169.
77. Owen OE, et al. Brain metabolism during fasting. J Clin Invest 1967, 46:1589.
78. Persson B, et al. Diabetes in pregnancy. Reviews in Perinatal Medicine 1978, 1-55. Raven Press, New York. E.M. Scarpelli, E.V. Cosmi (Eds.).
79. Sann L, et al. Effect of intravenous L-alanine administration on plasma glucose, insulin, and glucagon, blood pyruvate, lactate, and beta-hydroxybutyrate concentrations in newborn infants. Acta Paediatr Scand 1978, 67:297.
80. Goodwin LS, et al. Relationship between cerebrospinal fluid and blood lactate in low birth weight infants. Pediatr Res 1980, 14:632.
81. Stanley CA, et al. Metabolic fuel and hormone responses to fasting in newborn infants. Pediatrics 1979, 64:613.
82. Stemberg ZK, Hodr J The relationship between the blood levels of glucose, lactic acid, and pyruvic acid in the mother and in both umbilical vessels of the healthy fetus. Biol Neonate 1966, 10:227.
83. Hellman J, et al. Blood-brain barrier permeability to lactic acid in the newborn dog: lactate as a cerebral metabolic fuel. Pediatr Res 1982, 16:40.
84. Cremer JE Substrate utilization and brain development. J Cereb Blood Flow Metab 1982, 2:394.
85. Cremer JE, et al. Kinetics of blood-brain barrier transport of pyruvate, lactate, and glucose in suckling, weanling, and adult rats. J Neurochem 1979, 33:439.
86. Pessin JE, et al. Mammalian facilitative glucose transporter family: structure and molecular regulation. Am Rev Physiol 1992, 54:911.
87. Vannucci SJ, et al. Glucose transporter proteins in brain: delivery of glucose to neurons and glia. Glia 1997, 21:2.
88. Maher F, et al. Glucose transporter proteins in brain. FASEB J 1994, 8:1003.
89. Price NT, et al. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem J 1998, 329:321.
90. Vannucci SJ, et al: Developmental expression of the monocarboxylate transporter proteins in rat brain. J Neurochem (in press).
91. Vannucci SJ Developmental expression of GLUT1 and GLUT3 glucose transporters in brain. J Neurochem 1994, 62:240.
92. Vannucci SJ, et al. Effects of hypoxia-ischemia on GLUT1 and GLUT3 glucose transporters in immature brain. J Cereb Blood Flow Metab 1996, 16:77.
93. Nehlig A, et al. Autoradiographic measurement of local cerebral β-hydroxybutyrate uptake in the rat during postnatal development. Neuroscience 1991, 40:871.
94. Vannucci RC Hypoxic-ischemic encephalopathy. Neonatal-Perinatal Medicine 1997, 877-891. Mosby-Year Book, Philadelphia. A.A. Fanaroff, R.J. Martin (Eds.).
95. Vannucci RC Heterogeneity of hypoxic-ischemic thresholds in experimental animals. Brain Lesions in the Newborn 1994, 192-204. Munksgaard, Copenhagen. H.C. Lou (Ed.).
96. LaManna JC, et al. Oxygen insufficiency during hypoxic hypoxia in rat brain cortex. Brain Res 1984, 293:312.
97. Sugano T, et al. Mitochondrial functions under hypoxic conditions: the steady state of cytochrome c reduction and energy metabolism. Biochim Biophys Acta 1974, 347:340.
98. Hossmann K-A Treatment of experimental cerebral ischemia. J Cereb Blood Flow Metab 1982, 2:275.
99. Raichle ME The pathophysiology of brain ischemia. Ann Neurol 1983, 13:2.
100. Rice JE, et al. The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol 1981, 9:131.
101. Palmer C, et al. Carbohydrate and energy metabolism during the evolution of hypoxic-ischemic brain damage in the immature rat. J Cereb Blood Flow Metab 1990, 10:227.
102. Welsh FA, et al. Columnar alterations of NADH fluorescence during hypoxia-ischemia in immature rat brain. J Cereb Blood Flow Metab 1982, 2:221.
103. Yager JY, et al. Cerebral energy metabolism during hypoxia-ischemia and early recovery in the immature rat. Am J Physiol 1992, 262:H672.
104. Brown AW Structural abnormalities in neurons. J Clin Pathol 1977, 30(Suppl 11):155.
105. Brown AW, Brierley JB The earliest alterations in rat neurones and astrocytes after anoxia-ischaemia. Acta Neuropathol 1973, 23:9.
106. Linn F, et al. Mitochondrial respiration during recirculation after prolonged ischemia in cat brain. Exp Neurol 1987, 96:321.
107. Rehncroná S, et al. Recovery of brain mitochondrial function in the rat after complete and incomplete cerebral ischemia. Stroke 1979, 10:437.
108. Sims NR, Pulsinelli WA Altered mitochondrial respiration in selectively vulnerable brain subregions following transient forebrain ischemia in the rat. J Neurochem 1987, 49:1367.
109. Vannucci RC, et al. Cerebral glucose and energy utilization during the evolution of hypoxic-ischemic brain damage in the immature rat. J Cereb Blood Flow Metab 1994, 14:279.
110. Dora et, et al. Kinetics of microcirculatory NAD/NADH, and electrocorticographic changes in cat brain cortex during ischemia and recirculation. Ann Neurol 1986, 19:536.
111. Kogure K, et al. The dissociation of cerebral blood flow, metabolism, and function in the early stages of developing cerebral infarction. Ann Neurol 1980, 8:278.
112. Hope PL, et al. Cerebral energy metabolism studied with phosphorus NMR spectroscopy in normal and birth-asphyxiated infants. Lancet 1984, 2:366.
113. Azzopardi D, et al. Prognosis of newborn infants with hypoxic-ischemic brain injury assessed by phosphorus magnetic resonance spectroscopy. Pediatr Res 1989, 25:451.
114. Lorek A, et al. Delayed ("secondary") cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy. Pediatr Res 1994, 36:699.
115. Penrice J, et al. Proton magnetic resonance spectroscopy of the brain during acute hypoxia-ischemia and delayed cerebral energy failure in the newborn piglet. Pediatr Res 1997, 41:795.
116. Saugstad OD Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res 1988, 23:143.
117. Myers RE A unitary theory of causation of anoxic and hypoxic brain pathology. Cerebral Hypoxia and Its Consequence 1979, 195-213. Raven Press, New York. S. Fahn (Ed.).
118. Rehncroná S, et al. Excessive cellular acidosis: an important mechanism of neuronal damage in the brain?. Acta Physiol Scand 1980, 110:435.
119. Rehncroná S, et al. Brain lactic acidosis and ischemic cell damage. I. Biochemistry and neurophysiology. J Cereb Blood Flow Metab 1981, 1:297.
120. Goldman SA, et al. The effects of extracellular acidosis on neurons and glia in vitro. J Cereb Blood Flow Metab 1989, 9:471.
121. Kraig RP, et al. Hydrogen ions kill brain at concentrations reached in ischemia. J Cereb Blood Flow Metab 1987, 7:379.
122. Petito CK, et al. Light and electron microscopic evaluation of hydrogen ion-induced brain necrosis. J Cereb Blood Flow Metab 1987, 7:625.
123. Gardiner M, et al. Influence of blood glucose concentration on brain lactate accumulation during severe hypoxia and subsequent recovery of brain energy metabolism. J Cereb Blood Flow Metab 1982, 2:429.
124. Ginsberg MD, et al. Deleterious effect of glucose pretreatment on recovery form diffuse cerebral ischemia in the cat. I. Local cerebral blood flow and glucose utilization. Stroke 1980, 11:347.
125. Paschen W, et al. Lactate and pH in the brain: association and dissociation in different pathophysiological states. J Neurochem 1987, 48:154.
126. Yager JY, et al. Cerebral oxidative metabolism and redox state during hypoxia-ischemia and early recovery in the immature rat. Am J Physiol 1991, 261:H1102.
127. Penrice J, et al. Proton magnetic resonance spectroscopy of the brain in normal preterm and term infants, and early changes after perinatal hypoxia-ischemia. Pediatr Res 1996, 40:6.
128. Amess PN, et al. Early brain proton magnetic resonance spectroscopy and neonatal neurology related to neurodevelopmental outcome at 1 year in term infants after presumed hypoxic-ischaemic brain injury. Dev Med Child Neurol 1999, 41:436.
129. Robertson NJ, et al. Cerebral intracellular lactic alkalosis persisting months after neonatal encephalopathy measured by magnetic resonance spectroscopy. Pediatr Res 1999, 46:287.