Cytokeratin15-positive basal epithelial cells targeted in graft-versus-host disease express a constitutive antiapoptotic phenotype

Journal of Investigative Dermatology

Volumn 127, Issue 1, 2007, Pages 106-115

  Zhan, Qian ^a   Signoretti, Sabina ^a   Whitaker Menezes, Diana ^b   Friedman, Thea M ^c   Korngold, Robert ^c   Murphy, George F ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c HACKENSACK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN; CYTOKERATIN 15; MESSENGER RNA; PROTEIN BAX; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BASAL CELL; CELL POPULATION; CELL PROTECTION; EPITHELIUM CELL; FEMALE; GENE CONTROL; GRAFT VERSUS HOST REACTION; LASER; MALE; MICRODISSECTION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; EPITHELIAL CELLS; FEMALE; GRAFT VS HOST DISEASE; KERATIN-15; KERATINOCYTES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS;

EID: 33845750961     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700583     Document Type: Article

References (33)

1. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215:403-10
2. Bickenbach JR (1981) Identification and behavior of label-retaining cells in oral mucosa and skin. J Dent Res 60:1611-20
3. Cheng EH, Levine B, Boise LH, Thompson CB, Hardwick JM (1996) Bax-independent inhibition of apoptosis by Bcl-XL. Nature 379:554-6
4. Cotsarelis G, Sun TT, Lavker RM (1990) Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61:1329-37
5. Gho CG, Braun JEF, Tilli CMLJ, Neumann HAM, Ramaekers FCS (2004) Human follicular stem cells: their presence in plucked hair and follicular cell culture. Br J Dermatol 150:860-8
6. Gilliam A, Whitaker-Menezes D, Korngold R, Murphy GF (1996) Apoptosis is the predominant form of epithelial target cell injury in acute experimental graft-versus-host disease. J Invest Dermatol 107:377-83
7. Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ (1991) BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA 88:6961-5
8. Jones SC, Friedman TM, Murphy GF, Korngold R (2004) Specific donor Vβ-associated CD4 T-cell responses correlate with severe acute graft-versus-host disease directed to multiple minor histocompatibility antigens. Biol Blood Marrow Transplant 10:91-105
9. Kaur P, Li A, Redevers R, Bertoncello I (2004) Keratinocyte stem cell assays: an evolving science. J Investig Dermatol Symp Proc 9:238-47
10. Kim H, Whartenby KA, Georgantas RW, Wingard J, Civin CI (2002a) Human CD34+ hematopoietic stem/progenitor cells express high levels of FLIP and are resistant to Fas-mediated apoptosis stem. Cells 20:174-82
11. Kim JC, Whitaker-Menezes D, Deguchi M, Adair B, Korngold R, Murphy GF (2002b) Novel expression vascular cell adhesion molecule-1 (CD106) by squamous epithelium in experimental acute graft-versus-host disease. Am J Pathol 161:763-70
12. Korngold R, Marini JC, de Baca ME, Murphy GF, Giles-Komar J (2003) Role of tumor necrosis factor-alpha in graft-versus-host disease and graft-versus-leukemia responses. Biol Blood Marrow Transplant 9:292-303
13. Langley RG, Walsh N, Nevill T, Thomas L, Rowden G (1996) Apoptosis is the mode of keratinocyte death in cutaneous graft-versus-host disease. J Am Acad Dermatol 35:187-90
14. Lavker RM, Sun T-T (1982) Heterogeneity in basal epidermal keratinocytes: morphologic and functional correlations. Science 215:1239-41
15. Lindeman N, Waltregny D, Signoretti S, Loda M (2002) Gene transcript quantitation by real-time RT-PCR in cells selected by immunohistochemistrylaser capture microdissection. Diagn Mol Pathol 11:187-92
16. Liu Y, Lyle S, Yang Z, Cotsarelis G (2003) Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge. J Invest Dermatol 121:963-8
17. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)). Methods 25:402-8
18. Lyle S, Christofidou-Solomidou M, Liu Y, Elder DE, Albelda S, Cotsarelis G (1998) The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Sci 111:3179-88
19. Morris RJ, Liu Y, Marles L, Yang Z, Trempus C, Li S et al. (2004) Capturing and profiling adult hair follicle stem cells. Nat Biotechnol 22:411-7
20. Murphy GF, Korngold R (2004) Significance of selectively-targeted apoptotic rete cells in graft-versus-host disease. Biol Blood Marrow Transplant 10:357-65
21. Murphy GF, Lavker RM, Whitaker D, Korngold R (1991) Cytotoxic folliculitis in acute graft-versus-host disease. Evidence of follicular stem cell injury and recovery. J Cutan Pathol 18:309-14
22. Polakowska RR, Piacentini M, Bartlett R, Goldsmith LA, Haake AR (1994) Apoptosis in human skin development: morphogenesis, periderm, and stem cells. Dev Dyn 199:176-88
23. Sale GE, Beauchamp MD, Akiyama M (1994a) Parafollicular bulges, but not hair bulb keratinocytes, are attacked in graft-versus-host disease of human skin. Bone Marrow Transplant 14:411-3
24. Sale GE, Raff RF, Storb R (1994b) Stem cell regions in filiform papillae of tongue as targets of graft-versus-host disease. Transplantation 58:1273-5
25. Sale GE, Shulman HM, Gallucci BB, Thomas ED (1985) Young rete ridge keratinocytes are preferred targets in cutaneous graft-versus-host disease. Am J Pathol 118:278-87
26. Schmaltz C, Alpdognan O, Muriglan SJ, Kappel BJ, Rotolo JA, Ricchetti ET et al. (2003) Donor T cell-derived TNF is required for graft-versus-host disease, graft-versus-tumor activity, and complete T cell chimerism after bone marrow transplantation. Blood 101:2440-5
27. Tiberio R, Marconi A, Fila C, Fumelli C, Pignatti M, Krajewski S et al. (2002) Keratinocytes enriched for stem cells are protected from anoikis via an integrin signaling pathway in a Bcl-2 dependent manner. FEBS Lett 524:139-44
28. Wagner JL, Murphy GF (2005) Pathology and pathogenesis of cutaneous graft-versus-host disease. In: Graft-vs-host disease (Cooke K, Ferrara JL, eds), 3rd ed, New York: Marcel Dekker, 229-55
29. Waseem A, Dogan B, Tidman N, Alam Y, Purkis P, Jackson S et al. (1999) Keratin 15 expression is stratified epithelia: downregulation in activated keratinocytes. J Invest Dermatol 112:362-9
30. Webb A, Li A, Kaur P (2004) Location and phenotype of human adult keratinocyte stem cells of the skin. Differentiation 72:387-395
31. Werner S, Werner S, Munz B (2000) Suppression of keratin 15 expression by transforming growth factor beta in vitro and by cutaneous injury in vivo. Exp Cell Res 254:80-90
32. Whitaker-Menezes D, Jones SC, Friedman TM, Korngold R, Murphy GF (2003) An epithelial target site in experimental graft-versus-host disease and cytokine-mediated cytotoxicity is defined by cytokeratin 15 expression. Biol Blood Marrow Transplant 9:559-70
33. Xu X, Lyle S, Liu Y, Solky B, Cotsarelis G (2003) Differential expression of cyclin D1 in the human hair follicle. Am J Pathol 163:969-978