Compaction of islets is detrimental to transplant outcome in mice

Transplantation

Volumn 82, Issue 11, 2006, Pages 1472-1476

  Merani, Shaheed ^a   Schur, Colleen ^a   Truong, Wayne ^a   Knutzen, Victor K ^a   Lakey, Jonathan R T ^a   Anderson, Colin C ^a   Ricordi, Camillo ^b   Shapiro, A M James ^a,c  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Glucose homeostasis; Islet injury; Islet transplantation

Indexed keywords

GLUCOSE; INSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOLOGICAL MONITORING; CONTROLLED STUDY; EXPERIMENTAL MODEL; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; GRAFT RECIPIENT; HISTOLOGY; HORMONE DETERMINATION; IMPLANTATION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; TREATMENT OUTCOME;

ANIMALS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; GRAFT SURVIVAL; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; MICE, INBRED BALB C; MICE, INBRED STRAINS; TISSUE AND ORGAN HARVESTING;

EID: 33845718541     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.tp.0000243166.64244.3d     Document Type: Article

References (17)

1. Corlett MP, Scharp DW. The effect of pancreatic warm ischemia on islet isolation in rats and dogs. J Surg Res 1988; 45(6): 531.
2. Ketchum RJ, Nicolae M, Jahr H, et al. Analysis of donor age and cold ischemia time as factors in cadaveric human islet isolation. Transplant Proc 1994; 26(2): 596.
3. Lakey JR, Kneteman NM, Rajotte RV, et al. Effect of core pancreas temperature during cadaveric procurement on human islet isolation and functional viability. Transplantation 2002; 73(7): 1106.
4. Rose NL, Palcic MM, Shapiro AM, Lakey JR. Endogenous pancreatic enzyme activity levels show no significant effect on human islet isolation yield. Cell Transplant 2004; 13(2): 153.
5. Emamaullee J, Liston P, Korneluk RG, et al. XIAP overexpression in islet beta-cells enhances engraftment and minimizes hypoxia-reperfusion injury. Am J Transplant 2005; 5(6): 1297.
6. Hering BJ, Matsumoto I, Sawada T, et al. Impact of two-layer pancreas preservation on islet isolation and transplantation. Transplantation 2002; 74(12): 1813.
7. Ricordi C, Fraker C, Szust J, et al. Improved human islet isolation outcome from marginal donors following addition of oxygenated perfluorocarbon to the cold-storage solution. Transplantation 2003; 75(9): 1524.
8. Avila JG, Tsujimura T, Oberholzer J, et al. Improvement of pancreatic islet isolation outcomes using glutamine perfusion during isolation procedure. Cell Transplant 2003; 12(8): 877.
9. Contreras JL, Eckstein C, Smyth CA, et al. Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death. Diabetes 2004; 53(11): 2804.
10. Suarez-Pinzon WL, Lakey JR, Brand SJ, Rabinovitch A. Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet {beta}-cells from pancreatic duct cells and an increase in functional {beta}-cell mass. J Clin Endocrinol Metab 2005; 90(6): 3401.
11. Davalli AM, Ogawa Y, Ricordi C, et al. A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice. Transplantation 1995; 59(6): 817.
12. Davalli AM, Ogawa Y, Scaglia L, et al. Function, mass, and replication of porcine and rat islets transplanted into diabetic nude mice. Diabetes 1995; 44(1): 104.
13. Lacy PE, Kostianovsky M. Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 1967; 16(1): 35.
14. Gotoh M, Maki T, Kiyoizumi T, et al. An improved method for isolation of mouse pancreatic islets. Transplantation 1985; 40(4): 437.
15. Emamaullee JA, Rajotte RV, Liston P, et al. XIAP overexpression in human islets prevents early posttransplant apoptosis and reduces the islet mass needed to treat diabetes. Diabetes 2005; 54(9): 2541.
16. Migliavacca B, Nano R, Antonioli B, et al. Identification of in vitro parameters predictive of graft function: a study in an animal model of islet transplantation. Transplant Proc 2004; 36(3): 612.
17. Weir GC, Bonner-Weir S. Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes 2004; 53 Suppl 3: S16.