The murine Pou6f2 gene is temporally and spatially regulated during kidney embryogenesis and its human homolog is overexpressed in a subset of Wilms tumors

Journal of Pediatric Hematology/Oncology

Volumn 28, Issue 12, 2006, Pages 791-797

  Renzo, Francesca Di ^a   Doneda, Luisa ^a   Menegola, Elena ^a   Sardella, Michele ^b   Vecchi, Giovanna De ^b   Collini, Paola ^b   Spreafico, Filippo ^b   Fossati Bellani, Franca ^b   Giavini, Erminio ^a   Radice, Paolo ^b,c   Perotti, Daniela ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

^c FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

Author keywords

Kidney embryogenesis; Pou6f2; Wilms tumor; Wt1

Indexed keywords

MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR POU6F2; WT1 PROTEIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EPITHELIUM; FEMALE; FETUS; GENE EXPRESSION; GENETIC REGULATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; KIDNEY DEVELOPMENT; MALE; MESENCHYME; MORPHOGENESIS; MOUSE; NEPHROBLASTOMA; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGANOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; STAINING;

ADULT; AGED; ANIMALS; CELL DIFFERENTIATION; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KIDNEY; MALE; MESODERM; MICE; ORGANOGENESIS; POU DOMAIN FACTORS; TUMOR STEM CELLS; WILMS TUMOR; WT1 PROTEINS;

EID: 33845706340     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0b013e31802d3e65     Document Type: Article

References (24)

1. Beckwith JB. Wilm's tumor and other renal tumors of childhood. In: Finegold M, ed. Pathology of Neoplasia in Children and Adolescent. Philadelphia: WB Saunders; 1986:313-332.
2. Call KM, Glaser T, Ito CY, et al. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell. 1990;60:509-520.
3. Bonetta L, Kuehn SE, Huang A, et al. Wilms tumor locus on 11p13 defined by multiple CpG island-associated transcripts. Science. 1990;250:994-997.
4. Gessler M, Poustka A, Cavenee W, et al. Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping. Nature. 1990;343:774-778.
5. Rauscher FJ III. The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor. FASEB J. 1993;7:896-903.
6. Hastie ND. The genetics of Wilms' tumor - a case of disrupted development. Annu Rev Genet. 1994;28:523-558.
7. Dome JS, Coppes MJ. Recent advances in Wilms tumor genetics. Curr Opin Pediatr. 2002;14:5-11.
8. Ruteshouser EC, Huff V. Familial Wilms tumor. Am J Med Genet C Semin Med Genet. 2004;129:29-34.
9. Perotti D, De Vecchi G, Testi MA, et al. Germline mutations of the POU6F2 gene in Wilms tumors with loss of heterozygosity on chromosome 7p14. Hum Mutat. 2004;24:400-407.
10. Phillips K, Luisi B. The virtuoso of versatility: POU proteins that flex to fit. J Mol Biol. 2000;302:1023-1039.
11. Zhou H, Yoshioka T, Nathans J. Retina-derived POU-domain factor-1: a complex POU-domain gene implicated in the development of retinal ganglion and amacrine cells. J Neurosci. 1996;16:2261-2274.
12. Doneda L, Bulfamante G, Grimoldi MG, et al. Localization of fos, jun, kit and SCF mRNA in human placenta throughout gestation using in situ RT-PCR. Early Pregnancy. 1997;3:265-271.
13. Perotti D, Vecchi GD, Lualdi E, et al. Wilms tumor in monozygous twins: clinical, pathological, cytogenetic and molecular case report. J Pediatr Hematol Oncol. 2005;27:521-525.
14. Pritchard-Jones K, Fleming S, Davidson D, et al. The candidate Wilms' tumour gene is involved in genitourinary development. Nature. 1990;346:194-197.
15. Pelletier J, Schalling M, Buckler AJ, et al. Expression of the Wilms' tumor gene WT1 in the murine urogenital system. Genes Dev. 1991;5:1345-1356.
16. Park S, Schalling M, Bernard A, et al. The Wilms tumour gene WT1 is expressed in murine mesoderm-derived tissues and mutated in a human mesothelioma. Nature Genet. 1993;4:415-420.
17. Armstrong JF, Pritchard-Jones K, Bickmore WA, et al. The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo. Mech Dev. 1992;40:85-97.
18. Buckler AJ, Pelletier J, Haber DA, et al. Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development. Mol Cell Biol. 1991;11:1707-1712.
19. Rackley RR, Flenniken AM, Kuriyan NP, et al. Expression of the Wilms' tumor suppressor gene WT1 during mouse embryogenesis. Cell Growth Differ. 1993;4:1023-1031.
20. Rivera MN, Haber D. Wilm's tumour: connecting tumorigenesis and organ development in the kidney. Nat Rev Cancer. 2005;5:699-712.
21. Wagner KD, Wagner N, Vidal VP, et al. The Wilms' tumor gene Wt1 is required for normal development of the retina. EMBO J. 2002;21:1398-1405.
22. Wagner KD, Wagner N, Schley G, et al. The Wilms' tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b). Gene. 2003;305:217-223.
23. Jin ZG, Liu L, Zhong H, et al. Second intron of mouse nestin gene directs its expression in pluripotent embryonic carcinoma cells through POU factor binding site. Acta Biochim Biophys Sin. 2006;38:207-212.
24. Wagner N, Wagner KD, Scholz H, et al. The intermediate filament protein nestin is expressed in the developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1. Am J Physiol Regul Integr Comp Physiol. 2006;291:779-787.