Zone 3 predominance of histopathological features in nonalcoholic steatohepatitis

NASH and Nutritional Therapy

Volumn , Issue , 2005, Pages 50-57

  Enzan, Hideaki ^a   Toi, Makoto ^a   Hayashi, Yoshihiro ^a   Hamauzu, Tadashi ^a   Kuroda, Naoto ^a   Hiroi, Makoto ^a  

^a KOCHI UNIVERSITY   (Japan)

Author keywords

Hepatic stellate cell; Histopathology; Liver acinus; NASH; Zone 3 fibrosis

Indexed keywords

EID: 33845704763     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/4-431-27172-4_3     Document Type: Chapter

References (17)

1. Ludwig J, Viggiano TR, Mcgill DB, Ott BJ (1980) Nonalcoholic steatohepatitis, Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 55: 434-438
2. Brunt EM, Janney CG, Bisceglie AMD,Neuschwandler-Tetri BA, Bacon BR (1999) Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 94: 2467-2474
3. Brunt EM (2001) Nonalcoholic steatohepatitis: definition and pathology. Semin Liver Dis 21:3-16
4. Caldwell SH, Oelsner DH, Iezzoni JC, Hespenheide EE, Battle EH, Driscoll CJ (1999) Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease. Hepatology 29: 664-669
5. Contos MJ, Sanyal AJ (2002) The clinicopathologic spectrum and management of nonalcoholic fatty liver disease. Adv Anat Pathol 9: 37-51
6. Ayata G, Gordon FD, Lewis WD, Pomfret E, Pomposelli JJ, Jenkins RL, Khettry U (2002) Cryptogenic cirrhosis: clinicopathologic findings at and after liver transplantation. Hum Pathol 33: 1098-1104
7. Weltman MD, Farrell GC, Hall P, Ingelman-Sundberg M, Liddle C (1998) Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology 27: 128-133
8. Leclercq IA, Farrell GC, Field J, Bell DR, Gonzalez FJ, Robertson GR (2000) CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. J Clin Invest 105: 1067-1075
9. Chitturi S, Farrell GC (2001) Etiopathogenesis of nonalcoholic steatohepatitis. Semin Liver Dis 21: 27-41
10. Day CP (1998) Steatohepatitis: a tale of two 'hits'. Gastroenterology 114: 842-845
11. Parola M, Pinzani M, Casini A, Albano E, Poli G, Gentilini A, Gentilini P, Dianzani MU (1993) Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen a1(I) gene expression in human liver fat-storing cells. Biochem Biophys Res Commun 194: 1044-1050
12. Seki S, Kitada T, Yamada T, Sakaguchi H, Nakatani K,Wakasa K (2002) In situ detection of lipid peroxidation and oxidative DNA damage in non-Alcoholic fatty liver diseases. J Hepatol 37: 56-62
13. Lefkowitch JH, Haythe JH, Regent N (2002) Kupffer cell aggregation and perivenular distribution in steatohepatitis. Mod Pathol 15: 699-704
14. Enzan H, Himeno H, Iwamura S, Saibara T, Onishi S, Yamamoto Y, Hara H (1994) Immunohistochemical identification of Ito cells and their myofibroblastic transformation in adult human liver. Virchows Arch 424: 249-256
15. Potter JJ, Womack L, Mezey E, Anania FA (1998) Transdifferentiation of rat hepatic stellate cells results in leptin expression. Biochem Biophys Res Commun 244: 178-182
16. Washington K, Wright K, Shyr Y, Hunter EB, Olson S, Raiford DS (2000) Hepatic stellate cell activation in nonalcoholic steatohepatitis and fatty liver. Hum Pathol 31: 822-828
17. Cortez-Pinto H, Baptista A, Camilo ME, de Moura MC (2001) Hepatic stellate cell activation occurs in nonalcoholic steatohepatitis. Hepato-gastroenterology 48: 87-90