Clinical outcomes of childhood lupus nephritis: A single center's experience

Pediatric Nephrology

Volumn 22, Issue 2, 2007, Pages 222-231

  Lee, Byong Sop ^a   Cho, Hee Yeon ^a   Kim, Eo Jin ^a   Kang, Hee Gyung ^a   Ha, Il Soo ^a   Cheong, Hae Il ^a   Kim, Joong Gon ^a   Lee, Hyun Soon ^b   Choi, Yong ^a  

^a Seoul National University Children's Hospital   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

Author keywords

Anti phospholipid antibody; Cyclophosphamide pulse therapy; Lupus nephritis; Renal flare; Renal outcome; Risk factors

Indexed keywords

ANTIHYPERTENSIVE AGENT; ANTITHROMBOCYTIC AGENT; AZATHIOPRINE; CORTICOSTEROID; CYCLOPHOSPHAMIDE; DIURETIC AGENT; ENALAPRIL; IMMUNOSUPPRESSIVE AGENT; MESNA; METHYLPREDNISOLONE; MIZORIBINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PHOSPHOLIPID ANTIBODY; PREDNISOLONE;

ADOLESCENT; AMENORRHEA; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; AVASCULAR NECROSIS; CATARACT; CHILD; CHILDHOOD DISEASE; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; DEATH; DISEASE CLASSIFICATION; DISEASE COURSE; DISEASE EXACERBATION; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG MEGADOSE; DRUG TREATMENT FAILURE; FEMALE; GLAUCOMA; GLOMERULOSCLEROSIS; GONADAL DISEASE; HERPES ZOSTER; HUMAN; HUMAN TISSUE; HYPERTENSION; IMMUNOSUPPRESSIVE TREATMENT; KAPLAN MEIER METHOD; KIDNEY BIOPSY; LEUKOCYTE COUNT; LOW DRUG DOSE; LUPUS ERYTHEMATOSUS NEPHRITIS; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MILIARY TUBERCULOSIS; MULTIVARIATE ANALYSIS; NEPHRITIS; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROTEINURIA; REMISSION; RETROSPECTIVE STUDY; RISK FACTOR; SEPSIS; SEX DIFFERENCE; SIDE EFFECT; STEVENS JOHNSON SYNDROME; SURVIVAL RATE; SURVIVAL TIME;

ADOLESCENT; ANTIPHOSPHOLIPID SYNDROME; CHILD; CHILD, PRESCHOOL; DISEASE PROGRESSION; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KAPLAN-MEIERS ESTIMATE; KIDNEY FAILURE, CHRONIC; KOREA; LUPUS NEPHRITIS; MALE; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL RATE;

EID: 33845699453     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-006-0286-0     Document Type: Article

References (55)

1. Costallat LT, Coimbra AM (1994) Systemic lupus erythematosus: Clinical and laboratory aspects related to age at disease onset. Clin Exp Rheumatol 12:603-607
2. Font J, Cervera R, Espinosa G, Pallares L, Ramos-Casals M, Jimenez S, Garcia-Carrasco M, Seisdedos L, Ingelmo M (1998) Systemic lupus erythematosus (SLE) in childhood: Analysis of clinical and immunological findings in 34 patients and comparison with SLE characteristics in adults. Ann Rheum Dis 57:456-459
3. Gloor JM (1998) Lupus nephritis in children. Lupus 7:639-643
4. Bakkaloglu A (2001) Lupus nephropathy in children. Nephrol Dial Transplant 16 [Suppl 6]:126-128
5. Perfumo F, Martini A (2005) Lupus nephritis in children. Lupus 14:83-88
6. Klein-Gitelman M, Reiff A, Silverman ED (2002) Systemic lupus erythematosus in childhood. Rheum Dis Clin North Am 28:561-577
7. Cameron JS (1999) Lupus nephritis. J Am Soc Nephrol 10:413-424
8. Emre S, Bilge I, Sirin A, Kilicaslan I, Nayir A, Oktem F, Uysal V (2001) Lupus nephritis in children: Prognostic significance of clinicopathological findings. Nephron 87:118-126
9. Barbano G, Gusmano R, Damasio B, Alpigiani MG, Buoncompagni A, Gattorno M, Perfumo F (2002) Childhood-onset lupus nephritis: A single-center experience of pulse intravenous cyclophosphamide therapy. J Nephrol 15:123-129
10. Bogdanovic R, Nikolic V, Pasic S, Dimitrijevic J, Lipkovska-Markovic J, Eric-Marinkovic J, Ognjanovic M, Minic A, Stajic N (2004) Lupus nephritis in childhood: A review of 53 patients followed at a single center. Pediatr Nephrol 19:36-44
11. Wang LC, Yang YH, Lu MY, Chiang BL (2004) Retrospective analysis of the renal outcome of pediatric lupus nephritis. Clin Rheumatol 23:318-323
12. Hagelberg S, Lee Y, Bargman J, Mah G, Schneider R, Laskin C, Eddy A, Gladman D, Urowitz M, Hebert D, Silverman E (2002) Long term follow up of childhood lupus nephritis. J Rheumatol 29:2635-2642
13. Austin HA 3rd, Klippel JH, Balow JE, le Riche NG, Steinberg AD, Plotz PH, Decker JL (1986) Therapy of lupus nephritis. Controlled trial of prednisone and cytotoxic drugs. N Engl J Med 314:614-619
14. Boumpas DT, Austin HA 3rd, Vaughn EM, Klippel JH, Steinberg AD, Yarboro CH, Balow JE (1992) Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis. Lancet 340:741-745
15. Yee CS, Gordon C, Dostal C, Petera P, Dadoniene J, Griffiths B, Rozman B, Isenberg DA, Sturfelt G, Nived O, Turney JH, Venalis A, Adu D, Smolen JS, Emery P (2004) EULAR randomized controlled trial of pulse cyclophosphamide and methylprednisolone versus continuous cyclophosphamide and prednisolone followed by azathioprine and prednisolone in lupus nephritis. Ann Rheum Dis 63:525-529
16. Chan TM, Tse KC, Tang CS, Mok MY, Li FK; Hong Kong Nephrology Study Group (2005) Long-term study of mycophenolate mofetil as continuous induction and maintenance treatment for diffuse proliferative lupus nephritis. J Am Soc Nephrol 16:1076-1084
17. Contreras G, Pardo V, Leclercq B, Lenz O, Tozman E, O'Nan P, Roth D (2004) Sequential therapies for proliferative lupus nephritis. N Engl J Med 350:971-980
18. Baqi N, Moazami S, Singh A, Ahmad H, Balachandra S, Tejani A (1996) Lupus nephritis in children: A longitudinal study of prognostic factors and therapy. J Am Soc Nephrol 7:924-929
19. Schwartz GJ, Brion LP, Spitzer A (1987) The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children and adolescents. Pediatr Clin North Am 34:571-590
20. Moroni G, Quaglini S, Maccario M, Banfi G, Ponticelli C (1996) "Nephritic flares" are predictors of bad long-term renal outcome in lupus nephritis. Kidney Int 50:2047-2053
21. National Kidney Foundation (2002) K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Am J Kidney Dis 39 [2 Suppl 1]:S1-S266
22. Wilson WA, Gharavi AE, Koike T, Lockshin MD, Branch DW, Piette JC, Brey R, Derksen R, Harris EN, Hughes GR, Triplett DA, Khamashta MA (1999) International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: Report of an international workshop. Arthritis Rheum 42:1309-1311
23. Churg J, Bernstein J, Glassock RJ (1995) Renal disease. Ikagu-Shoin, Tokyo, pp 151-179
24. Austin HA 3rd, Muenz LR, Joyce KM, Antonovych TT, Balow JE (1984) Diffuse proliferative lupus nephritis: Identification of specific pathologic features affecting renal outcome. Kidney Int 25:689-695
25. Yoo CW, Kim MK, Lee HS (2000) Predictors of renal outcome in diffuse proliferative lupus nephropathy: Data from repeat renal biopsy. Nephrol Dial Transplant 15:1604-1608
26. Hong CY (2001) Pediatrics, 7th edn. Korean Textbook Press, Seoul, pp 1233-1237
27. Wang LC, Yang YH, Lu MY, Chiang BL (2003) Retrospective analysis of mortality and morbidity of pediatric systemic lupus erythematosus in the past two decades. J Microbiol Immunol Infect 36:203-208
28. Mok CC, Mak A, Chu WP, To CH, Wong SN (2005) Long-term survival of southern Chinese patients with systemic lupus erythematosus: A prospective study of all age-groups. Medicine (Baltimore) 84:218-224
29. Cervera R, Khamashta MA, Font J, Sebastiani GD, Gil A, Lavilla P, Mejia JC, Aydintug AO, Chwalinska-Sadowska H, de Ramon E, Fernandez-Nebro A, Galeazzi M, Valen M, Mathieu A, Houssiau F, Caro N, Alba P, Ramos-Casals M, Ingelmo M, Hughes GR; European Working Party on Systemic Lupus Erythematosus (2003) Morbidity and mortality in systemic lupus erythematosus during a 10-year period: A comparison of early and late manifestations in a cohort of 1,000 patients. Medicine (Baltimore) 82:299-308
30. Lahita RG (1999) The role of sex hormones in systemic lupus erythematosus. Curr Opin Rheumatol 11:352-356
31. Cameron JS (1994) Lupus nephritis in childhood and adolescence. Pediatr Nephrol 8:230-249
32. Wallace DJ, Podell T, Weiner J, Klinenberg JR, Forouzesh S, Dubois EL (1981) Systemic lupus erythematosus - survival patterns. Experience with 609 patients. JAMA 245:934-938
33. Ward MM, Studenski S (1990) Systemic lupus erythematosus in men: A multivariate analysis of gender differences in clinical manifestations. J Rheumatol 17:220-224
34. Austin HA 3rd, Boumpas DT, Vaughan EM, Balow JE (1994) Predicting renal outcomes in severe lupus nephritis: Contributions of clinical and histologic data. Kidney Int 45:544-550
35. Austin HA 3rd, Muenz LR, Joyce KM, Antonovych TA, Kullick ME, Klippel JH, Decker JL, Balow JE (1983) Prognostic factors in lupus nephritis. Contribution of renal histologic data. Am J Med 75:382-391
36. Nossent HC, Henzen-Logmans SC, Vroom TM, Berden JH, Swaak TJ (1990) Contribution of renal biopsy data in predicting outcome in lupus nephritis. Analysis of 116 patients. Arthritis Rheum 33:970-977
37. Schwartz MM, Lan SP, Bernstein J, Hill GS, Holley K, Lewis EJ (1992) Role of pathology indices in the management of severe lupus glomerulonephritis. Lupus Nephritis Collaborative Study Group. Kidney Int 42:743-748
38. Magil AB, Puterman ML, Ballon HS, Chan V, Lirenman DS, Rae A, Sutton RA (1988) Prognostic factors in diffuse proliferative lupus glomerulonephritis. Kidney Int 34:511-517
39. Ioannidis JP, Boki KA, Katsorida ME, Drosos AA, Skopouli FN, Boletis JN, Moutsopoulos HM (2000) Remission, relapse, and re-remission of proliferative lupus nephritis treated with cyclophosphamide. Kidney Int 57:258-264
40. Illei GG, Takada K, Parkin D, Austin HA, Crane M, Yarboro CH, Vaughan EM, Kuroiwa T, Danning CL, Pando J, Steinberg AD, Gourley MF, Klippel JH, Balow JE, Boumpas DT (2002) Renal flares are common in patients with severe proliferative lupus nephritis treated with pulse immunosuppressive therapy: Long-term follow up of a cohort of 145 patients participating in randomized controlled studies. Arthritis Rheum 46:995-1002
41. El Hachmi M, Jadoul M, Lefebvre C, Depresseux G, Houssiau FA (2003) Relapses of lupus nephritis: Incidence, risk factors, serology and impact on outcome. Lupus 12:692-696
42. Moroni G, Quaglini S, Maccario M, Banfi G, Ponticelli C (1996) "Nephritic flares" are predictors of bad long-term renal outcome in lupus nephritis. Kidney Int 50:2047-2053
43. Massengill SF, Hedrick C, Ayoub EM, Sleasman JW, Kao KJ (1997) Antiphospholipid antibodies in pediatric lupus nephritis. Am J Kidney Dis 29:355-361
44. Bhandari S, Harnden P, Brownjohn AM, Turney JH (1998) Association of anticardiolipin antibodies with intraglomerular thrombi and renal dysfunction in lupus nephritis. QJM 91:401-409
45. Frampton G, Hicks J, Cameron JS (1991) Significance of anti-phospholipid antibodies in patients with lupus nephritis. Kidney Int 39:1225-1231
46. Gulko PS, Reveille JD, Koopman WJ, Burgard SL, Bartolucci AA, Alarcon GS (1993) Anticardiolipin antibodies in systemic lupus erythematosus: clinical correlates, HLA associations, and impact on survival. J Rheumatol 20:1684-1693
47. Farrugia E, Torres VE, Gastineau D, Michet CJ, Holley KE (1992) Lupus anticoagulant in systemic lupus erythematosus: A clinical and renal pathological study. Am J Kidney Dis 20:463-471
48. Moroni G, Ventura D, Riva P, Panzeri P, Quaglini S, Banfi G, Simonini P, Bader R, Meroni PL, Ponticelli C (2004) Antiphospholipid antibodies are associated with an increased risk for chronic renal insufficiency in patients with lupus nephritis. Am J Kidney Dis 43:28-36
49. Alarcon-Segovia D, Boffa MC, Branch W, Cervera R, Gharavi A, Khamashta M, Shoenfeld Y, Wilson W, Roubey R (2003) Prophylaxis of the antiphospholipid syndrome: A consensus report. Lupus 12:499-503
50. Flanc RS, Roberts MA, Strippoli GF, Chadban SJ, Kerr PG, Atkins RC (2004) Treatment of diffuse proliferative lupus nephritis: A meta-analysis of randomized controlled trials. Am J Kidney Dis 43:197-208
51. Wetzels JF (2004) Cyclophosphamide-induced gonadal toxicity: A treatment dilemma in patients with lupus nephritis? Neth J Med 62:347-352
52. Huong du L, Amoura Z, Duhaut P, Sbai A, Costedoat N, Wechsler B, Piette JC (2002) Risk of ovarian failure and fertility after intravenous cyclophosphamide. A study in 84 patients. J Rheumatol 29:2571-2576
53. Ioannidis JP, Katsifis GE, Tzioufas AG, Moutsopoulos HM (2002) Predictors of sustained amenorrhea from pulsed intravenous cyclophosphamide in premenopausal women with systemic lupus erythematosus. J Rheumatol 29:2129-2135
54. Beimler JH, Andrassy K (2004) Cyclophosphamide treatment in systemic necrotizing vasculitis and lupus nephritis. How long? How much? Pediatr Nephrol 19:949-955
55. Houssiau FA, Vasconcelos C, D'Cruz D, Sebastiani GD, de Ramon Garrido E, Danieli MG, Abramovicz D, Blockmans D, Mathieu A, Direskeneli H, Galeazzi M, Gul A, Levy Y, Petera P, Popovic R, Petrovic R, Sinico RA, Cattaneo R, Font J, Depresseux G, Cosyns JP, Cervera R (2004) Early response to immunosuppressive therapy predicts good renal outcome in lupus nephritis: Lessons from long-term follow up of patients in the Euro-Lupus Nephritis Trial. Arthritis Rheum 50:3934-3940