Synthesis of bisdesmosidic kryptogenyl saponins using the 'random glycosylation' strategy and evaluation of their antitumor activity

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 1, 2007, Pages 156-160

  Liu, Yang ^a   Zhao, Dong Mei ^a   Lu, Xue Hua ^a   Wang, Hui ^a   Chen, Hong ^b   Ke, Ying ^b   Leng, Ling ^b   Cheng, Mao Sheng ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b MEDICAL COLLEGE OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

Author keywords

Antitumor activity; Kryptogenin glycosides; Random glycosylation; Steroidal saponins

Indexed keywords

3BETA,26 DIHYDROXY 25 CHOLEST 5 EN 16,22 DIONE; BISDESMOSIDIC KRYPTOGENYL SAPONIN DERIVATIVE; CHOLESTANE DERIVATIVE; SAPONIN DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; EVALUATION; GLYCOSYLATION; HELA CELL; HUMAN; HUMAN CELL; STEROID ANALYSIS;

ANTINEOPLASTIC AGENTS; DRUG SCREENING ASSAYS, ANTITUMOR; GLYCOSIDES; GLYCOSYLATION; HELA CELLS; HUMANS; SAPONINS; STEROIDS;

EID: 33845681978     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.09.071     Document Type: Article

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27. We also attempted to use three glycosyl donors in one random reaction. Unfortunately, the corresponding sublibrary generated was too complex to be analyzed and separated. So far, at best three components are suitable in our research.