No differences in efficacy between noncultured and cultured islets in reducing hyperglycemia in a nonvascularized islet graft model

Diabetes Technology and Therapeutics

Volumn 8, Issue 5, 2006, Pages 536-545

  Bohman, Sara ^a   Andersson, Arne ^a   King, Aileen ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

ALLOXAN DIABETES MELLITUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL GRAFT; CELL CULTURE; CELL ISOLATION; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE OXIDATION; GLUCOSE TOLERANCE; HYPERGLYCEMIA; INSULIN RELEASE; MALE; MICROENCAPSULATION; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; REVASCULARIZATION; TREATMENT OUTCOME;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; HYPERGLYCEMIA; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MICE; MICE, INBRED C57BL; NEOVASCULARIZATION, PHYSIOLOGIC; TISSUE CULTURE TECHNIQUES;

EID: 33845681669     PISSN: 15209156     EISSN: None     Source Type: Journal    
DOI: 10.1089/dia.2006.8.536     Document Type: Article

References (19)

1. The Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977-986.
2. Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM, Rajotte RV: Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000;343:230-238.
3. Penn I: Post-transplant malignancy: the role of immunosuppression. Drug Saf 2000;23:101-113.
4. Sun AM, Goosen MF, O'Shea G: Microencapsulated cells as hormone delivery systems. Crit Rev Ther Drug Carrier Syst 1987;4:1-12.
5. Lim F, Sun AM: Microencapsulated islets as bioartificial endocrine pancreas. Science 1980;210:908-910.
6. King A, Sandler S, Andersson A, Hellerstrom C, Kulseng B, Skjak-Braek G: Glucose metabolism in vitro of cultured and transplanted mouse pancreatic islets microencapsulated by means of a high-voltage electrostatic field. Diabetes Care 1999;22(Suppl 2):B121-B126.
7. Andersson A, Sandler S: Viability tests of cryopreserved endocrine pancreatic cells. Cryobiology 1983;20:161-168.
8. Olsson R, Carlsson PO: Better vascular engraftment and function in pancreatic islets transplanted without prior culture. Diabetologia 2005;48:469-476.
9. King A, Lock J, Xu G, Bonner-Weir S, Weir GC: Islet transplantation outcomes in mice are better with fresh islets and exendin-4 treatment. Diabetologia 2005;48:2074-2079.
10. Ballinger WF, Lacy PE: Transplantation of intact pancreatic islets in rats. Surgery 1972;72:175-186.
11. Kemp CB, Knight MJ, Scharp DW, Lacy PE, Ballinger WF: Transplantation of isolated pancreatic islets into the portal vein of diabetic rats. Nature 1973;244:447.
12. Brown J, Molnar IG, Clark W, Mullen Y: Control of experimental diabetes mellitus in rats by transplantation of fetal pancreases. Science 1974;184:1377-1379.
13. Korsgren O, Jansson L, Sandler S, Andersson A: Hyperglycemia-induced B cell toxicity. The fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background. J Clin Invest 1990;86:2161-2168.
14. King A, Lau J, Nordin A, Sandler S, Andersson A: The effect of capsule composition in the reversal of hyperglycemia in diabetic mice transplanted with microencapsulated allogeneic islets. Diabetes Technol Ther 2003;5:653-663.
15. Andersson A, Korsgren O, Jansson L: Intraportally transplanted pancreatic islets revascularized from hepatic arterial system. Diabetes 1989;38(Suppl 1):192-195.
16. Menger MD, Jaeger S, Walter P, Feifel G, Hammersen F, Messmer K: Angiogenesis and hemodynamics of microvasculature of transplanted islets of Langerhans. Diabetes 1989;38(Suppl 1):199-201.
17. Korbutt GS, Mallett AG, Ao Z, Flashner M, Rajotte RV: Improved survival of microencapsulated islets during in vitro culture and enhanced metabolic function following transplantation. Diabetologia 2004;47:1810-1818.
18. Calafiore R, Basta G, Luca G, Lemmi A, Montanucci MP, Calabrese G, Racanicchi L, Mancuso F, Brunetti P: Microencapsulated pancreatic islet allografts into nonimmunosuppressed patients with type 1 diabetes: first two cases. Diabetes Care 2006;29:137-138.
19. Leblond FA, Simard G, Henley N, Rocheleau B, Huet PM, Halle JP: Studies on smaller (approximately 315 microM) microcapsules: IV. Feasibility and safety of intrahepatic implantations of small alginate poly-L-lysine microcapsules. Cell Transplant 1999;8:327-337.