Single-cell detection using optofluidic intracavity spectroscopy

IEEE Sensors Journal

Volumn 6, Issue 6, 2006, Pages 1543-1550

  Shao, Hua ^a,b   Kumar, Dhiraj ^a,b,c   Lear, Kevin L ^a,b  

^a IEEE   (United States)

^b Engineering Research Center and Hydraulics Laboratory   (United States)

^c OptiComp Corporation   (United States)

Author keywords

Biological cell differentiation; Intracavity spectroscopy; Microfluidic cavity; Transmission spectra; Transverse mode

Indexed keywords

BIOLOGICAL CELL DIFFERENTIATION; MICROFLUIDIC CAVITY; OPTOFLUIDIC INTRACAVITY SPECTROSCOPY; TRANSMISSION SPECTRA; TRANSVERSE MODE;

BIOSENSORS; BLOOD; DEMODULATION; MICROSCOPIC EXAMINATION; POLYSTYRENES; REFRACTIVE INDEX; SPECTROSCOPIC ANALYSIS; YEAST;

CELLS;

EID: 33845675046     PISSN: 1530437X     EISSN: None     Source Type: Journal    
DOI: 10.1109/JSEN.2006.884512     Document Type: Article

References (20)

1. J. Beuthan, O. Minet, J. Helfmann, M. Herrig, and G. Muller, "The spatial variation of the refractive index in biological cells," Phys. Med. Biol., vol. 41, no. 3, pp. 369-382, 1996.
2. V. Backman, M. B. Wallace, L. T. Arendt et al., "Detection of preinvasive cancer cells," Nature, vol. 406, no. 6791, pp. 35-36, Jul. 2000.
3. J. Emmelkamp, F. Wolbers, H. Andersson, R. S. DaCosta, B. C. Wilson, I. Vermes, and A. V. D. Berg, "The potential of auto fluorescence for the detection of single living cells for label-free cell sorting in microfluidic systems," Electrophoresis, vol. 25, no. 21/22, pp. 3740-3745, Nov. 2004.
4. A. C. Romano, E. M. Espana, S. H. Yoo, M. T. Budak, J. M. Wolosin, and S. C. G. Tseng, "Different cell sizes in human limbal and central corneal basal epithelia measured by confocal microscopy and flow cytometry," Investig. Ophthalmol. Vis. Sci., vol. 44, no. 12, pp. 5125-5129, 2003.
5. C. G. Xie and Y. Q. Li, "Confocal micro-Raman spectroscopy of single biological cells using optical trapping and shifted excitation difference techniques," J. Appl. Phys., vol. 93, no. 5, pp. 2982-2986, Mar. 2003.
6. R. S. Gurajar, V. Backman, L. T. Perelman, I. Georgakoudi et al., "Imaging human epithelial properties with polarized light scattering spectroscopy," Nat. Med., vol. 7, no. 11, pp. 1245-1248, 2001.
7. P. B. Tarsa, A. D. Wist, P. Rabinowitz, and K. K. Lehmann, "Single-cell detection by cavity ring-down spectroscopy," Appl. Phys. Lett., vol. 85, no. 19, pp. 4523-4525, Nov. 2004.
8. A. Katz, A. Alimova, M. Xu, E. Rudolph, M. K. Shah, H. E. Savage, R. B. Rosen, S. A. McCormick, and R. R. Alfano, "Bacteria size determination by elastic light scattering," IEEE J. Sel. Topics Quantum Electron., vol. 9, no. 2, pp. 277-287, Mar./Apr. 2003.
9. X. J. Liang, A. Q. Liu, X. M. Zhang, P. H. Yap, T. C. Ayi, and H. S. Yoon, "Determination of refractive index of single living cell using integrated biochip," in Proc. 13th Int. Conf. Solid-State Sens., Actuators, Microsyst., 2005, pp. 1712-1715.
10. Y. Zhang, K. L. Cooper, and A. B. Wang, "Multicavity Fabry-Perot interferometric thin-film sensor with built-in temperature compensation," IEEE Photon. Technol. Lett., vol. 17, no. 12, pp. 2712-2714, Dec. 2005.
11. P. L. Gourley, "Biocavity laser for high-speed cell and tumor biology," J. Appl. Phys. D, vol. 36, no. 14, pp. R228-R239, 2003.
12. D. Kumar, H. Shao, and K. L. Lear, "Microfluidic cavity surface emitting laser based biosensor," in Proc. 17th Annu. Meeting IEEE LEOS, Nov. 2004, vol. 1, pp. 118-119.
13. H. Shao, D. Kumar, S. A. Feld, and K. L. Lear, "Micro-fluidic passive cavity interferometer based biosensor," in Proc. 17th Annu. Meeting IEEE LEOS, Nov. 2004, vol. 1, pp. 120-121.
14. K. E. Meissner, P. L. Gourley, T. M. Brennan, B. E. Hammons, and A. E. McDonald, "Intracavity spectroscopy in vertical cavity surface-emitting lasers for micro-optical-mechanical systems," Appl. Phys. Lett., vol. 69, no. 11, pp. 1517-1519, Sep. 1996.
15. A. E. Siegman, Lasers. Mill Valley, CA: Univ. Sci., 1986, ch. 19 and 21.
16. G. Smith, B. K. Pierscionek, and D. A. Atchison, "The optical modeling of the human lens," Ophthalmic Physiol. Opt., vol. 11, no. 4, pp. 359-369, Oct. 1991.
17. H. Shao, D. Kumar, S. A. Feld, and K. L. Lear, "Fabrication of a Fabry-Perot cavity in a microfluidic channel using thermocompressive gold bonding of glass substrates," J. Microelectromech. Syst., vol. 14, no. 4, pp. 756-762, Aug. 2005.
18. T. Klaassen, J. D. Jong, M. V. Exter, and J. P. Woerdman, "Transverse mode coupling in an optical resonator," Opt. Lett., vol. 30, no. 15, pp. 1959-1961, Aug. 2005.
19. E. Gratton, S. Breusegem, N. Barry, Q. Ruan, and J. Eid, "Fluctuation correlation spectroscopy in cells: Determination of molecular aggregation," in Biophotonics-Optical Science and Engineering for the 21st Century, Norwell, MA: Kluwer, 2004.
20. P. Schwille, F. J. MeyerAlmes, and R. Rigler, "Dual-color fluorescence cross-correlation spectroscopy for multicomponent diffusional analysis in solution," Biophys J., vol. 72, no. 4, pp. 1878-1886, Apr. 1997.