Enhanced neuronal activation in central autonomic network nuclei in aged mice following acute peripheral immune challenge

Autonomic Neuroscience: Basic and Clinical

Volumn 131, Issue 1-2, 2007, Pages 137-142

  Gaykema, Ronald P A ^a   Balachandran, Madhu K ^a   Godbout, Jonathan P ^b   Johnson, Rodney W ^b   Goehler, Lisa E ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Amygdala; Brainstem; Catecholaminergic neurons; Central autonomic network; Circumventricular organ; Hypothalamus; Inflammation; Lipopolysaccharide; Normal aging; Sickness

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; PROTEIN C FOS;

AGING; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BAGG ALBINO MOUSE; BLOOD BRAIN BARRIER; BRAIN STEM; CATECHOLAMINE NERVE CELL; CONTROLLED STUDY; ILLNESS BEHAVIOR; IMMUNOHISTOCHEMISTRY; INFECTION; INFLAMMATION; MALE; MOUSE; NERVE CELL STIMULATION; NONHUMAN; PONS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION;

AGE FACTORS; AGING; ANIMALS; BRAIN STEM; CELL COUNT; DRUG ADMINISTRATION ROUTES; IMMUNOHISTOCHEMISTRY; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED BALB C; NEURONS; PROTO-ONCOGENE PROTEINS C-FOS; TYROSINE 3-MONOOXYGENASE;

EID: 33845673533     PISSN: 15660702     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autneu.2006.07.005     Document Type: Article

References (30)

1. Barrientos R.M., Higgins E.A., Biedenkapp J.C., Sprunger D.B., Wright-Hardesty K.J., Watkins L.R., Rudy J.W., and Maier S.F. Peripheral infection and aging interact to impair hippocampal memory consolidation. Neurobiol. Aging 27 (2006) 723-732
2. Blatteis C.M. Endotoxic fever: new concepts of its regulation suggests new approaches to its management. Pharmacol. Ther. 111 (2006) 194-223
3. Bruunsgaard H., Pedersen M., and Pedersen B.K. Aging and proinflammatory cytokines. Curr. Opin. Hematol. 8 (2001) 131-136
4. Buller K.M., and Day T.A. Systemic administration of interleukin-1beta activates select populations of central amygdala afferents. J. Comp. Neurol. 452 (2002) 288-296
5. Cunningham Jr. E.T., Wada E., Carter D.B., Tracey D.E., Battey J.F., and DeSouza E.B. In situ histochemical localization of type 1 IL-1 receptor RNA in the central nervous system, pituitary, and adrenal gland of the mouse. J. Neurosci. 12 (1992) 1101-1114
6. Dantzer R. Cytokine-induced sickness behavior: a neuroimmune response to activation of innate immunity. Eur. J. Pharmacol. 500 (2004) 399-411
7. Ek M., Kurosawa M., Lundeberg T., and Ericsson A. Activation of vagal afferents after intravenous injection of interleukin1β: role of endogenous prostaglandins. J. Neurosci. 18 (1998) 9471-9479
8. Ericsson A., Kovacs K.J., and Sawchenko P.E. A functional neuroanatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons. J. Neurosci. 14 (1994) 897-913
9. Gaykema R.P.A., Goehler L.E., Tilders F.J.H., Bol J.G.M., McGorry M.M., Maier S.F., and Watkins L.R. Bacterial endotoxin induces Fos immunoreactivity in primary afferent neurons of the vagus nerve. Neuroimmunomodulation 5 (1998) 234-240
10. Godbout J.P., Chen J., Abraham J., Richwine A.F., Berg B.M., Kelley K.W., and Johnson R.W. Exaggerated neuroinflammation and sickness in aged mice following activation of the peripheral innate immune system. FASEB J. 19 (2005) 1329-1331
11. Goehler L.E., Gaykema R.P.A., Hammack S.E., Maier S.F., and Watkins L.R. Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve. Brain Res. 804 (1998) 306-310
12. Goehler L.E., Gaykema R.P.A., Nguyen K.T., Lee J.L., Tilders F.J.H., Maier S.F., and Watkins L.R. Interleukin-1β in immune cells of the abdominal vagus nerve: an immune to nervous system link?. J. Neurosci. 19 (1999) 2799-2806
13. Goehler L.E., Gaykema R.P.A., Hansen M.K., Anderson K., Maier S.F., and Watkins L.R. Vagal immune-to-brain communication: a visceral chemosensory pathway. Auton. Neurosci. 85 (2000) 49-59
14. Goehler L.E., Gaykema R.P.A., Opitz N., Reddaway R., Badr N., and Lyte M. Activation in vagal afferents and central autonomic pathways: early responses to intestinal infection with Campylobacter jejuni. Brain Behav. Immun. 19 (2005) 334-344
15. Goehler L.E., Erisir A., and Gaykema R.P.A. Neural-immune interface in the area postrema. Neurosci. 140 (2006) 1415-1434
16. Holmes C., El-Okl M., Williams A.L., Cunningham C., Wilcockson D., and Perry V.H. Systemic infection, interleukin-1beta, and cognitive decline in Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 74 (2003) 788-789
17. Konsman J.P., Kelley K., and Dantzer R. Temporal and spatial relationships between lipopolysaccharide-induced expression of Fos, interleukin-1β and inducible nitric oxide synthase in rat brain. Neurosci. 89 (1999) 535-548
18. Krabbe K.S., Pedersen M., and Bruunsgaard H. Inflammatory mediators in the elderly. Exp. Gerontol. 39 (2004) 687-699
19. LaFlamme N., and Rivest S. Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components. FASEB J. 15 (2001) 155-163
20. Lee H.Y., Whiteside M.B., and Herkenham M. Area postrema removal abolishes stimulatory effects of intravenous interleukin-1β on hypothalamic-pituitary-adrenal axis activity and c-fos mRNA in the hypothalamic paraventricular nucleus. Brain Res. Bull. 46 (1998) 495-503
21. Lee C.-K., Weindruch R., and Prolla T. Gene-expression profile of the ageing brain in mice. Nat. Genet. 25 (2000) 294-297
22. Lu J., Zhang Y.-H., Chou T.C., Gaus S.E., Elmquist J.K., Shiromani P., and Saper C.B. Contrasting effects of ibotenate lesions of the paraventricular nucleus and subparaventricular zone on sleep-wake cycle and temperature regulation. J. Neurosci. 21 (2001) 4864-4874
23. Maier S.F., and Watkins L.R. Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. Psychol. Rev. 105 (1998) 83-107
24. Marvel F.A., Chen C.-C., Badr N.A., Gaykema R.P.A., and Goehler L.E. Reversible inactivation of the dorsal vagal complex blocks lipopolysaccharide-induced social withdrawal and c-Fos expression in central autonomic nuclei. Brain Behav. Immun. 18 (2004) 123-143
25. Nadjar A., Bluthe R.-M., May M.J., Dantzer R., and Parnet P. Inactivation of the cerebral NFκB pathway inhibits interleukin-1β-induced sickness behavior and c-Fos expression in various brain nuclei. Neuropsychopharmacology 30 (2005) 1492-1499
26. Perry V.H., Newman T.A., and Cunningham C. The impact of systemic infection on the progression of neurodegenerative disease. Nat. Rev., Neurosci. 4 (2003) 103-112
27. Pinner R.W., Teutsch S.M., Simonsen L., Klug L.A., Graber J.M., Clarke M.J., and Berkelman R.L. Trends in infectious diseases mortality in the United States. JAMA 275 (1996) 189-193
28. Strandberg T.E., Pitkala K.H., Linnavuori K.H., and Tilvis R.S. Impact of viral and bacterial burden on cognitive impairment in elderly persons with cardiovascular diseases. Stroke 34 (2003) 2126-2131
29. Tkacs N.C., and Li J. Immune stimulation induces Fos expression in brainstem amygdala afferents. Brain Res. Bull. 48 (1999) 223-231
30. Wan W., Janz L., Vriend C.Y., Sorensen C.M., Greenberg A.H., and Nance D.M. Differential induction of c-Fos immunoreactivity in hypothalamus and brain stem nuclei following central and peripheral administration of endotoxin. Brain Res. Bull. 32 (1993) 581-587