Three cases of toxic skin eruptions associated with methotrexate and a compilation of methotrexate-induced skin eruptions

Dermatology Online Journal

Volumn 12, Issue 7, 2006, Pages

  Scheinfeld, Noah ^a  

^a ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETAMETHASONE; CYCLOPHOSPHAMIDE; DIDANOSINE; DOXORUBICIN; EFAVIRENZ; FOLIC ACID; METHOTREXATE; PREDNISOLONE; TENOFOVIR; VANCOMYCIN; VINCRISTINE; ABORTIVE AGENT; ANTINEOPLASTIC AGENT;

ABORTION; ADULT; ANAMNESIS; ARTICLE; BURKITT LYMPHOMA; CASE REPORT; CHORIOCARCINOMA; CLINICAL FEATURE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG MEGADOSE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; MALE; MONOTHERAPY; SKIN BIOPSY; SKIN EXAMINATION; SKIN TOXICITY; DRUG ERUPTION; MIDDLE AGED; PREGNANCY; REVIEW; UTERUS CANCER;

ABORTIFACIENT AGENTS, NONSTEROIDAL; ADULT; ANTINEOPLASTIC AGENTS; BURKITT LYMPHOMA; CHORIOCARCINOMA; DRUG ERUPTIONS; FEMALE; HIV INFECTIONS; HUMANS; MALE; METHOTREXATE; MIDDLE AGED; PREGNANCY; UTERINE NEOPLASMS;

EID: 33845666783     PISSN: None     EISSN: 10872108     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. http://www.rxlist.com/cgi/generic/mtx.htm (accessed November 10, 2005).
2. Haustein UF, Rytter M. Methotrexate in psoriasis: 26 years' experience with low-dose long-term treatment. J Eur Acad Dermatol Venereol. 2000;14:382-8.
3. Plantin P, Saraux A, Guillet G. Methotrexate in dermatology: current aspects. Ann Dermatol Venereol. 1989;116:109-15.
4. Zachariae H. Methotrexate side-effects. Br J Dermatol. 1990;122 Suppl 36:127-33.
5. Olsen EA. The pharmacology of methotrexate. J Am Acad Dermatol. 1991;25:306-18.
6. Harrison PV. Methotrexate-induced epidermal necrosis. Br J Dermatol. 1987;116:867-9.
7. Heenen M, Laporte M, Noel JC, de Graef C. Methotrexate induces apoptotic cell death in human keratinocytes. Arch Dermatol Res. 1998;290:240-5.
8. Bell R, Sullivan JR, Burdon JG, Sinclair R. Toxic rash associated with high dose methotrexate therapy. Clin Exp Pharmacol Physiol Suppl. 1979;5:57-61.
9. Squier CA. Oral complications of cancer therapies. Mucosal alterations. NCI Monogr. 1990;(9):169-72.
10. Squier CA, Kremer MJ. Biology of oral mucosa and esophagus. J Natl Cancer Inst Monogr. 2001;(29):7-15.
11. Gibbs S, Ponec M.Intrinsic regulation of differentiation markers in human epidermis, hard palate and buccal mucosa. Arch Oral Biol. 2000;45:149-58.
12. Reynaert H, De Coninck A, Neven AM, Van Camp B, Schots R. Chemotherapy-induced acral erythema and acute graft-versus-host disease after allogeneic bone marrow transplantation. Bone Marrow Transplant. 1992;10:185-7.
13. Morris GM, Hamlet R, Hopewell JW. The cell kinetics of the epidermis and follicular epithelium of the rat: variations with age and body site. Cell Tissue Kinet. 1989;22:213-22.
14. Johnson GK, Squier CA, Johnson WT, Todd GL. Blood flow and epithelial thickness in different regions of feline oral mucosa and skin. J Oral Pathol. 1987;16:317-21.
15. Huang IT, Lin WM, Shun CT, Hsieh ST. Influence of cutaneous nerves on keratinocyte proliferation and epidermal thickness in mice. Neuroscience. 1999;94:965-73.
16. Patatanian E, Thompson DF. Rico MJ, Kory WP, Gould EW, Penneys NS. Interface dermatitis in patients with the acquired immunodeficiency syndrome. J Am Acad Dermatol. 1987;16:1209-18.
17. Kharfan Dabaja MA, Morgensztern D, Markoe AM, Bartlett-Pandite L. Radiation recall dermatitis induced by methotrexate in a patient with Hodgkin's disease. Am J Clin Oncol. 2000;23:531-3.
18. Yang CH, Yang LJ, Jaing TH, Chan HL. Toxic epidermal necrolysis following combination of methotrexate and trimethoprim-sulfamethoxazole. Int J Dermatol. 2000;39:621-3.
19. Goerttler E, Kutzner H, Peter HH, Requena L. Methotrexate-induced papular eruption in patients with rheumatic diseases: a distinctive adverse cutaneous reaction produced by methotrexate in patients with collagen vascular diseases. J Am Acad Dermatol. 1999;40(5 Pt 1):702-7.
20. Halevy S, Giryes H, Avinoach I, Livni E, Sukenik S. Leukocytoclastic vasculitis induced by low-dose methotrexate: in vitro evidence for an immunologic mechanism. J Eur Acad Dermatol Venereol. 1998;10:81-5.
21. Simonart T, Durez P, Margaux J, Van Geertruyden J, Goldschmidt D, Parent D. Cutaneous necrotizing vasculitis after low dose methotrexate therapy for rheumatoid arthritis: a possible manifestation of methotrexate hypersensitivity. Clin Rheumatol. 1997;16:623-5.
22. Martins da Cunha AC, Rappersberger K, Gadner H. Toxic skin reaction restricted to palms and soles after high-dose methotrexate. Pediatr Hematol Oncol. 1991;8:277-80.
23. Straka M, Zeringue E, Goldman M. A rare drug reaction to methotrexate after treatment for ectopic pregnancy. Obstet Gynecol. 2004;103(5 Pt 2):1047-8.
24. Widemann BC, Balis FM, Shalabi A, Boron M, O'Brien M, Cole DE, Jayaprakash N, Ivy P, Castle V, Muraszko K, Moertel CL, Trueworthy R, Hermann RC, Moussa A, Hinton S, Reaman G, Poplack D, Adamson PC. Treatment of accidental intrathecal methotrexate overdose with intrathecal carboxypeptidase G2. J Natl Cancer Inst. 2004;96:1557-9.
25. Cetiner M, Sener G, Sehirli AO, Eksioglu-Demiralp E, Ercan F, Sirvanci S, Gedik N, Akpulat S, Tecimer T, Yegen BC. Taurine protects against methotrexate-induced toxicity and inhibits leukocyte death.Toxicol Appl Pharmacol. 2005;209:39-50.
26. Kohli A, Ferencz TM, Calderon JG. Readministration of high-dose methotrexate in a patient with suspected immediate hypersensitivity and T-cell acute lymphoblastic lymphoma. Allergy Asthma Proc. 2004;25:249-52.
27. Arevalo-Lopez A. Acute methotrexate toxicity in psoriasis. Gac Med Mex. 1999;135:513-6.
28. Pearce HP, Wilson BB. Erosion of psoriatic plaques: an early sign of methotrexate toxicity. J Am Acad Dermatol. 1996;35:835-8.