Combined clinical, thyroid ultrasound and cytological features help to predict thyroid malignancy in follicular and Hürthle cell thyroid lesions: Results from a series of 505 consecutive patients

Clinical Endocrinology

Volumn 66, Issue 1, 2007, Pages 13-20

  Rago, T ^a   Di Coscio, G ^c   Basolo, F ^d   Scutari, M ^a   Elisei, R ^a   Berti, P ^b   Miccoli, P ^b   Romani, R ^c   Faviana, P ^d   Pinchera, A ^a   Vitti, P ^a,d  

^a Department of Endocrinology ^*  (Italy)

^b Section of Cytopathology   (Italy)

^c Section of Pathology 1   (Italy)

^d UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CANCER RISK; CONTROLLED STUDY; CYTODIAGNOSIS; ECHOGRAPHY; FEMALE; GENDER; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PAPILLARY CARCINOMA; PRIORITY JOURNAL; THYROID CANCER; THYROID FOLLICLE CELL; THYROID GLAND; THYROID NODULE; THYROID PARAFOLLICULAR CELL; THYROIDECTOMY; TUMOR VOLUME; ULTRASOUND;

ADENOCARCINOMA, FOLLICULAR; ADENOMA; ADENOMA, OXYPHILIC; ADULT; BIOPSY, FINE-NEEDLE; CALCINOSIS; CARCINOMA, MEDULLARY; CARCINOMA, PAPILLARY, FOLLICULAR; CHI-SQUARE DISTRIBUTION; CYTODIAGNOSIS; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; HYPERPLASIA; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; THYROID GLAND; THYROID NEOPLASMS; THYROID NODULE;

EID: 33845661593     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2006.02677.x     Document Type: Article

References (41)

1. Mazzaferri, E.M. (1993) Management of a solitary thyroid nodule. The New England Journal of Medicine, 328, 553-559.
2. Ezzat, S., Sarti, D.A., Cain, D.R. & Braunstein, G.D. (1994) Thyroid incidentalomas: prevalence by palpation and ultrasonography. Archives of Internal Medicine, 154, 1838-1840.
3. Tan, G.H. & Gharib, H. (1997) Thyroid incidentalomas: management approaches to non-palpable nodules discovered incidentally on thyroid imaging. Annales of Internal Medicine, 126, 226-231.
4. Rago, T., Chiovato, L., Aghini-Lombardi, F., Grasso, L., Pinchera, A. & Vitti, P. (2001) Non-palpable thyroid nodules in a borderline iodine-sufficient area: detection by ultrasonography and follow-up. Journal of Endocrinology Investigation, 24, 770-776.
5. Gharib, H. (1994) Fine-needle aspiration biopsy of the thyroid nodules: advantages, limitations and effect. Mayo Clinic Procedure, 69, 44-49.
6. Suen, K.C. (2002) Fine-needle aspiration biopsy of the thyroid. Canadian Medicine Association Journal, 167, 491-495.
7. Goellner, J.R., Gharib, H., Grant, C.S. & Johnson, D.A. (1986) Fine needle aspiration cytology of the thyroid 1980 to 1986. Acta Cytologica, 31, 587-594.
8. Gardner, H.A.R., Ducatman, B.S. & Wang, H.H. (1993) Predictive value of fine needle aspiration of the thyroid in the classification of follicular lesions. Cancer, 71, 2598-2603.
9. Hamburger, J.I. (1994) Diagnosis thyroid nodules by fine needle biopsy: use and abuse. Journal of Clinical Endocrinology and Metabolism, 79, 335-339.
10. Smith, J., Cheifetz, R.E., Schneidereit, N., Berean, K. & Thomson, T. (2005) Can accurately predict benign follicular nodules? The American Journal of Surgery, 189, 592-595.
11. DeMay, R.M. (2000) Follicular lesions of the thyroid-W (h) ither follicular carcinoma? American Journal of Pathology, 114, 681-683.
12. Greaves, T.S., Olvera, M., Florentine, B.D., Raz, A.S., Cobb, C.J., Tsao-Wei, D.D., Groshen, S., Singer, P., Lopresti, J. & Martin, S.E. (2000) Follicular lesions of thyroid: a 5 year fine-needle aspiration experience. Cancer, 90, 335-341.
13. Carling, T. & Udelsman, R. (2005) Follicular neoplasm of the thyroid: what to recommend. Thyroid, 15, 583-587.
14. Baloch, Z.W., FleisherS., Livolsi, V.A. & Gupta, P.K. (2001) Diagnosis of 'follicular neoplasm': a gray zone in thyroid fine-needle aspiration cytology. Diagnostic Cytopathololgy, 26, 41-44.
15. Kini, S.R., Miller, J.M. & Hamburger, J.I. (1981) Cytopathology of Hürthle cell lesions of the thyroid gland by fine needle aspiration. Acta Cytologica, 25, 647-652.
16. Monzani, F., Caraccio, N., Iacconi, P., Faviana, P., Dardano, A., Basolo, F. & Miccoli, P. (2003) Prevalence of cancer in follicular thyroid nodules: is there still a role of intraoperative frozen section analysis? Thyroid, 13, 389-394.
17. Tuttle, R.M., Lemar, H. & Burch, H.B. (1998) Clinical features associated with an increased risk of thyroid malignancy in patients with follicular neoplasia by fine needle aspiration. Thyroid, 8, 377-383.
18. Davis, N.L., Gordon, M. & Germann, E. (1991) Clinical parameters predictive of malignancy of thyroid follicular neoplasm. American Journal of Surgery, 161, 567-569.
19. Raber, W., Kaserer, K., Niederle, B. & Vierhapper, H. (2000) Risk factors for malignancy of thyroid nodules initially identified as follicular neoplasia by fine needle aspiration: results of a prospective study of one hundred twenty patients. Thyroid, 10, 709-712.
20. Rago, T., Vitti, P., Chiovato, L., Mazzeo, S., De Liberi, A., Miccoli, P., Viacava, P., Bogazzi, F., Martino, E. & Pinchera, A. (1998) Role of conventional ultrasonography and color flow-doppler sonography in predicting malignancy in 'cold' thyroid nodules. European Journal of Endocrinology, 138, 41-46.
21. Papini, E., Guglielmi, R., Bianchini, A., Crescenzi, A., Taccagna, S., Nardi, F., Panunzi, C., Rinaldi, R., Toscano, V. & Pacella, C.M. (2002) Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features. Journal of Clinical Endocrinology and Metabolism, 87, 1941-1946.
22. Carpi, A., Ferrari, E., Toni, M.G., Sagripanti, A., Nicolini, A. & Di Coscio, G. (1996) Needle aspiration techniques in preoperative selection of patients with thyroid nodules: a long-term study. Journal of Clinical Oncology, 14, 1704-1712.
23. Bahar, G., Braslavsky, D., Shpitzer, T., Feinmesser, R., Avidan, S., Popovtzer, A. & Karl, S. (2003) The cytological and clinical value of the thyroid 'follicular lesion'. American Journal of Otolaryngology, 24, 217-220.
24. Goldestein, R.E., Netterville, J.L., Burkey, B. & Johnson, J.E. (2002) Implications of follicular neoplasms, atypia, and lesions suspicious for malignancy diagnosed by fine-needle aspiration of thyroid nodules. Annals of Surgery, 235, 656-664.
25. Salvatore, G., Giannini, R., Faviana, P., Caleo, A., Migliaccio, I., Fagin, J.A., Nikiforov, Y.E., Troncone, G., Palombini, L., Basolo, F. & Santoro, M. (2004) Analysis of BRAF point mutation and RET/PTC rearrangement refines the fine-needle aspiration diagnosis of papillary thyroid carcinoma. Journal of Clinical Endocrinology and Metabolism, 89, 5175-5180.
26. Guidelines of the Papanicolaou Society of Cytopathology for the examination of fine-needle aspiration specimens from thyroid nodules. (1996) The Papanicolaou Society of Cytopathology task force on standards of practice. Modern Pathology, 9, 710-715.
27. Heidinger, C.H.R. & Sobin, L.H. (1974) Histological typing of thyroid tumors. In: World Health Organization ed. International Histological Classification of Tumors. Roto Satag AS, Geneva, Switzerland, 17-27.
28. Silverman, J.F., West, R.L., Larkin, E.W., Park, H.K., Finley, J.L., Swanson, M.S. & Fore, W.W. (1986) The role of fine-needle aspiration biopsy in the rapid diagnosis and management of thyroid neoplasm. Cancer, 57, 1164-1170.
29. Piromalli, D., Martelli, G., Del Prato, I., Collini, P. & Pilotti, S. (1992) The role of fine needle aspiration in the diagnosis of thyroid nodules: analysis of consecutive cases. Journal of Surgery of Oncology, 50, 247-250.
30. Mesonero, C.E., Jugle, J.E., Wilbur, D.C. & Nayar, R. (1998) Fine-needle aspiration of the macrofollicular and microfollicular subtypes of the follicular variant of papillary carcinoma of the thyroid. Cancer Cytopathology, 84, 235-244.
31. Baloch, Z.W., LiVolsi, V. & A. (2003) Diagnostic dilemmas in the thyroid pathology: follicular variant of papillary carcinoma and classic papillary thyroid carcinoma arising in lymphocytic thyroiditis. Pathological Case Review, 8, 47-56.
32. Vasko, V.V., Gaudart, J., Allasia, C., Savchencho, V., Di Cristofaro, J., Saji, M., Ringel, M.D. & De Micco, C. (2004) Thyroid follicular adenomas may display feature of follicular carcinoma and variant of papillary carcinoma. European Journal of Endocrinologyy, 151, 779-786.
33. Nikiforova, M.N., Kimura, E.T., Gandhi, M., Biddinger, P.W., Knauf, J.A., Basolo, F., Zhu, Z., Giannini, R., Salvatore, G., Fusco, A., Santoro, M., Fagin, J.A. & Nikiforov, Y.E. (2003) BRAF mutations in thyroid tumors are restricted to papillary carcinoma and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas. Journal of Clinical Endocrinology and Metabolism, 88, 5399-5404.
34. Namba, H., Nakashima, M., Hayashi, N., Maeda, S., Rogounovitch, T.I., Ohtsuru, A., Saenko, V.A., Kanematsu, T. & Yamashita, S. (2003) Clinical implication and hot spot BRAF mutation, V599E, in papillary thyroid cancers. Journal of Clinical Endocrinology and Metabolism, 88, 4393-4697.
35. Elisei, R., Romei, C., Rago, T., Scutari, M., Bottici, V., Di Coscio, G., Basolo, F., Berti, P., Pinchera, A. & Vitti, P. (2005) Usefulness of molecular analysis of BRAF, mutation and RET/PTC rearrangements in fine needle aspiration (FNA) of thyroid nodules with cytology nondiagnostic for malignancies. Thyroid, 15, 79. 13th International Thyroid Congress. Buenos Aires, Brazil.
36. Baloch, Z.W. & LiVolsi, V.A. (2005) Pathologic diagnosis of papillary thyroid carcinoma: today and tomorrow. Expert Review of Molecular Diagnostics, 5, 573-584.
37. Carcangiu, M.L., Zampi, G., Pupi, A., Castagnoli, A. & Rosai, J. (1985) Papillary carcinoma of the thyroid: a clinico-pathologic study of 241 cases treated at the University of Florence. Italy Cancer, 55, 805-828.
38. Papotti, M., Rodriguez, J., De Pompa, R., Bartolazzi, A. & Rosai, J. (2005) Galectin-3 and HBME-1 expression in well-differentiated thyroid tumors with follicular architecture of uncertain malignant potential. Modern Pathology, 18, 571-546.
39. Schlinkert, R.T., van Heerden, J.A., Goellner, J.R., Garib, H., Smith, S.L., Rosales, R.F. & Weaver, A.L. (1997) Factors that predict malignant thyroid lesions when fine needle aspiration is 'suspicious for follicular neoplasm'. Mayo Clinics Proceedings, 72, 913-916.
40. Kelman, A.S., Rathan, A., Leibowitz, J., Burstein, D.E. & Haber, R.S. (2001) Thyroid cytology and the risk of malignancy in thyroid nodules: importance of nuclear atypia in indeterminate specimens. Thyroid, 11, 271-277.
41. McHenry, C.R., Thomas, S.R., Slusarczyk, S.J. & Khiyami, A. (1999) Follicular or Hυrthle cell neoplasms of the thyroid: can clinical factors be used to predict carcinoma and determine extent of thyroidectomy? Surgery, 126, 798-804.