Effect of drying time, ambient temperature and pre-soaks on prion-infected tissue contamination levels on surgical stainless steel: concerns over prolonged transportation of instruments from theatre to central sterile service departments

Journal of Hospital Infection

Volumn 65, Issue 1, 2007, Pages 72-77

  Lipscomb, I P ^a   Pinchin, H ^a   Collin, R ^a   Keevil, C W ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Cleaning chemistries; Decontamination; Episcopic differential interference contrast epi fluorescence microscopy; Prion disease; Sterile service departments; Surgical instruments

Indexed keywords

PRION PROTEIN; STAINLESS STEEL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL TEMPERATURE; HOSPITAL PURCHASING; IATROGENIC DISEASE; INSTRUMENT STERILIZATION; MICROBIAL CONTAMINATION; NONHUMAN; OPERATING ROOM; PRION; SIMULATION; SURGICAL INSTRUMENT;

CROSS INFECTION; DECONTAMINATION; DESICCATION; DISINFECTANTS; DISINFECTION; EQUIPMENT CONTAMINATION; EQUIPMENT REUSE; HUMANS; IATROGENIC DISEASE; KINETICS; MICROSCOPY, FLUORESCENCE; PRION DISEASES; PRPSC PROTEINS; STAINLESS STEEL; SURGICAL INSTRUMENTS; TEMPERATURE; TIME FACTORS;

EID: 33845658217     PISSN: 01956701     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhin.2006.09.025     Document Type: Article

References (23)

1. Hilton D.A., Ghani A.C., Conyers L., et al. Prevalence of lymphoreticular prion protein accumulation in UK tissue samples. J Pathol 203 (2004) 733-739
2. Peden A.H., Ritchie D.L., Head M.W., and Ironside J.W. Detection and localization of PrPSc in the skeletal muscle of patients with variant, iatrogenic, and sporadic forms of Creutzfeldt-Jakob disease. Am J Pathol 168 (2006) 927-935
3. Hunter N., Foster J., Chong A., et al. Transmission of prion diseases by blood transfusion. J Gen Virol 83 (2002) 2897-2905
4. Llewelyn C.A., Hewitt P.E., Knight R.S., et al. Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion. Lancet 363 (2004) 417-421
5. Peden A.H., Head M.W., Ritchie D.L., Bell J.E., and Ironside J.W. Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient. Lancet 364 (2004) 527-529
6. Bishop M., Hart P., Aitchison L., Baybutt H., and Plinston C. Predicting susceptibility and incubation time of human-to-human transmission of vCJD. Lancet Neurol 5 (2006) 393-398
7. Zobeley E., Flechsig E., Cozzio A., Enari M., and Weissmann C. Infectivity of scrapie prions bound to a stainless steel surface. Mol Med 5 (1999) 240-243
8. Flechsig E., Hegyi I., Enari M., Schwarz P., Collinge J., and Weissmann C. Transmission of scrapie by steel-surface-bound prions. Mol Med 7 (2001) 679-684
9. Bernoulli C., Siegfried J., Baumgartner G., et al. Danger of accidental person-to-person transmission of Creutzfeldt-Jakob disease by surgery. Lancet 1 (1977) 478-479
10. Collins S., and Masters C.L. Iatrogenic and zoonotic Creutzfeldt-Jakob disease: the Australian perspective. Med J Aust 164 (1996) 598-602
11. ACDP/SEAC. Transmissible spongiform encephalopathy agents: safe working and the prevention of infection (1998), The Stationery Office, London
12. Anon. A guide to the decontamination of reusable surgical instruments (2003), NHS Estates, London
13. Anon. Stategy for modernising the provision of decontamination services (2005), NHS Estates, London
14. Anon. Joint trade union response to the Department of Health: national decontamination stratergy (2006), Amicus GMB & Unison, London
15. Khammo N, McDonnell G. Institute of decontamination sciences-official reference book. Southampton, UK: Yeoman Publications Ltd; 2006.
16. Lipscomb I.P., Sihota A., Botham M., Harris K.L., and Keevil C.W. Rapid method for the sensitive detection of protein contamination on surgical instruments. J Hosp Infect 62 (2006) 141-148
17. Betmouni S., and Perry V.H. The acute inflammatory response in CNS following injection of prion brain homogenate or normal brain homogenate. Neuropathol Appl Neurobiol 25 (1999) 20-28
18. Lipscomb I.P., Sihota A., and Keevil C.W. Diathermy forceps and pencils - reservoirs for protein and prion contamination?. J Hosp Infect 64 (2006) 193-194
19. Anon. The management and control of hospital acquired infection in acute NHS trusts in England. National Audit Office (HC230). London: The Stationary Office; 2000.
20. Scottish Health Executive. Health in Scotland (2000), SNHS, Edinburgh
21. Anon. The decontamination of surgical instruments in the NHS in England-update report. 'A step change' (2005), NHS Estates, London
22. Huys J. The sterile supply cycle: cleaning. Sterilization of medical supplies by stream, Volume 1 General Theory. 2nd edn. (2006), Heart Consultancy, Renkum, The Netherlands. 90-75829-04-3
23. Sparrer H.E., Santoso A., Szoka Jr. F.C., and Weissman J.S. Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in vitro-converted Sup35 protein. Science 289 (2000) 595-599