Developmental dental toxicity of dioxin and related compounds - A review

International Dental Journal

Volumn 56, Issue 6, 2006, Pages 323-331

  Alaluusua, Satu ^a,b   Lukinmaa, Pirjo Liisa ^a  

^a University of Helsinki ^*

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Developmental dental defect; Dioxins; Human; Mouse; PAHs; PCBs; Rat; TCDD; Teeth

Indexed keywords

EID: 33845649810     PISSN: 00206539     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1875-595X.2006.tb00336.x     Document Type: Review

References (79)

1. U.S. Environmental Protection Agency. At: http://www.epa.gov/ncea/pdfs/ dioxin/dioxreass.htm.
2. Kiviranta H. Exposure and human PCDD/F and PCB body burden in Finland. Thesis. KTL, Kuopio, Finland, 2005.
3. Birnbaum LS, Tuomisto J. Non-carcinogenic effects of TCDD in animals. Food Addit Contam 2000 17: 275-288.
4. Kiukkonen A. Toxicity of Dioxin to Developing Teeth and Salivary glands. An Experimental Study. Thesis. Helsinki: University of Helsinki, Finland, 2006.
5. Uno S, Dalton TP, Derkenne S et al. Oral exposure to benzo[a]pyrene in the mouse: Detoxication by inducible cytochrome P450 is more important than metabolic activation. Mol Pharmacol 2004 65: 1225-1237.
6. Ramesh A, Walker SA, Hood DB et al. Bioavailability and risk assessment of orally ingested polycyclic aromatic hydrocarbons. Int J Toxicol 2004 23: 301-333.
7. Huisman M, Koopman-Esseboom C, Fidler V. Perinatal exposure to polychlorinated biphenyls and dioxins and its effect on neonatal neurological development. Early Hum Dev 1995 41: 111-127.
8. Lackmann G M, Göen T, Töllner U et al. PCBs and HCB in serum of full-term German neonates. Lancet 1996 348: 1035.
9. Vartiainen T, Saarikoski S, Jaakkola JJ et al. PCDD, PCDF, and PCB concentrations in human milk from two areas in Finland. Chemosphere 1997 34: 2571-2583.
10. Furst P, Furst C, Wilmers K. PCDDs and PCFs in human milk - a statistical evaluation of a 6-year survey. Chemosphere 1992 25: 1029-1038.
11. Schecter A, Birnbaum L, Ryan JJ et al. Dioxins: An overview. Environ Res 2006 101: 419-428.
12. ten Tusscher GW, Stam GA, Koppe JG. Open chemical combustions resulting in a local increased incidence of orofacial clefts. Chemosphere 2000 40: 1263-1270.
13. ten Tusscher GW, Koppe JG. Perinatal dioxin exposure and later effects - a review. Chemosphere 2004 54: 1329-1336.
14. Jacobson JL, Jacobson SW, Humphrey HE. Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive functioning in young children. J Pediatr 1990 116: 38-45.
15. Patandin S, Lanting CI, Mulder PG et al. Effects of environmental exposure to polychlorinated biphenyls and dioxins on cognitive abilities in Dutch children at 42 months of age. J Pediatr 1999 134: 33-41.
16. Weisglas-Kuperus N, Patandin S, Berbers GA et al. Immunologic effects of background exposure to polychlorinated biphenyls and dioxins in Dutch preschool children. Environ Health Perspect 2000 108: 1203-1207.
17. ten Tusscher GW, Steerenberg PA, van Loveren H et al. Persistent hematologic and immunologic disturbances in 8-year-old Dutch children associated with perinatal dioxin exposure. Environ Health Perspect 2003 111: 1519-1523.
18. Boström CE, Gerde P, Hanberg A et al. Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air. Environ Health Perspect 2002 110 Suppl 3: 451-488.
19. Abbott BD, Perdew GH, Birnbaum LS. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. Toxicol Appl Pharmacol 1994 126: 16-25.
20. Bryant PL, Clark GC, Probst MR et al. Effects of TCDD on Ah receptor, ARNT, EGF, and TGF-alpha expression in embryonic mouse urinary tract. Teratology 1997 55: 326-337.
21. Peters JM, Naratsky MG, Elizondo G et al. Amelioration of TCDD-induced teratogenesis in aryl hydrocarbon receptor (AHR)-null mice. Toxicol Sci 1999 47: 86-92.
22. Schmidt JV, Bradfield CA. AH receptor signaling pathways. Annu Rev Cell Dev Biol 1996 12: 55-89.
23. Nebert DW, Roe AL, Dieter MZ. Role of the aromatic hydrocarbon receptor and (Ah) gene battery in the oxidative stress response, cell cycle control and apoptosis. Biochem Pharmacol 2000 59: 65-85.
24. Carlson D, Perdew G. A dynamic role for Ah receptor in cell signalling? Insights from a diverse group of Ah receptor interacting proteins. J Biochem Mol Toxicol 2002 16: 317-325.
25. Marlowe JL, Puga A. Aryl hydrocarbon receptor, cell cycle regulation, toxicity and tumorigenesis. J Cell Biochem 2005 96: 1174-1184.
26. Pohjanvirta R, Wong JMT, Li W et al. Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain. Mol Pharmacol 1998 54: 86-94.
27. Simanainen U, Tuomisto JT, Tuomisto J et al. Structure-activity relationships and dose responses of polychlorinated dibenzo-p-dioxins for short-term effects in 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant and -sensitive rat strains. Toxicol Appl Pharmacol 2002 181: 38-47.
28. Jämsä T, Viluksela M, Tuomisto JT et al. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on bone in two rat strains with different aryl hydrocarbon receptor structures. J Bone Miner Res 2001 16: 1812-1820.
29. Miettinen HM, Pulkkinen P, Jämsä T et al. Effects of in utero and lactational TCDD exposure on bone development in differentially sensitive rat lines. Toxicol Sci 2005 85: 1003-1012.
30. Kattainen H, Tuukkanen J, Simanainen U et al. In utero/lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure impairs molar tooth development in rats. Toxicol Appl Pharmacol 2001 74: 216-224.
31. Kiukkonen A, Viluksela M, Sahlberg C et al. Response of the incisor tooth to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a dioxin-resistant and a dioxin-sensitive rat strain. Toxicol Sci 2002 69: 482-489.
32. Thomae TL, Stevens EA, Liss AL et al. The teratogenic sensitivity to 2,3,7,8-tetrachlorodibenzo-p-dioxin is modified by a locus on mouse chromosome 3. Mol Pharmacol 2006 69: 770-775.
33. Di Domenico A, Silano V, Viviano G et al. Accidental release of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at Seveso, Italy. IV. Vertical distribution of TCDD in soil. Ecotoxicol Environ Safety 1980 4: 327-338.
34. Mocarelli P, Pocchiari F, Nelson N. Preliminary report: 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure to humans - Seveso, Italy. Morb Mortal Wkly Rep 1988 48: 733-736.
35. Needham LL, Gerthoux PM, Patterson DG Jr et al. Serum dioxin levels in Seveso, Italy, population in 1976. Teratogen Carcinogen Mutagen 1997/1998 17: 225-240.
36. Alaluusua S, Calderara P, Gerthoux PM et al. Developmental dental aberrations after the dioxin accident in Seveso. Environ Health Perspect 2004 112: 1313-1318.
37. Kashimoto T, Miyata H. Differences between Yusho and other kinds of poisoning involving only PCBs. In Ward J S (ed) PCBs in the Environment. Pp 1-26 Boca Raton, USA: CRC Press, Inc, 1987.
38. Hsu S-T, Ma C-I, Hsu S et al. Discovery and epidemiology of PCB poisoning in Taiwan: a four-year follow-up. Environ Health Perspect 1985 59: 5-12.
39. Rogan WJ, Gladen BC, Hung KL et al. Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan. Science 1988 241: 334-336.
40. Funatsu I, Yamashita T, Yoshinake T et al. A chlorobiphenyl induced fetopathy. Fukuoka Acta Med 1971 62: 139-149.
41. Shimizu K, Nakata S, Murakami T et al. Long-term occlusal guidance of a severely intoxicated patient with yusho (PCB poisoning): A case report. Am J Orthod Dentofac Orthop 1992 101: 393-402.
42. Lan S-J, Yen Y, Ko Y-C et al. Growth and development of permanent teeth germs of transplacental Yu-Cheng babies in Taiwan. Bull Environ Contam Toxicol 1989 42: 931-934.
43. Wang S-L, Chen T-T, Hsu J-F et al. Neonatal and childhood teeth in relation to perinatal exposure to polychlorinated biphenyls and dibenzofurans: observations of the Yucheng children in Taiwan. Environ Res 2003 93: 131-137.
44. Hara I. Health status and PCBs in blood of workers exposed to PCBs, and of their children. Environ Health Perspect 1985 59: 85-90.
45. Jan J, Vrbič V. Polychlorinated biphenyls cause developmental enamel defects in children. Caries Res 2000 34: 469-473.
46. Hölttä P, Kiviranta H, Leppäniemi A et al. Developmental dental defects in children who reside by a river polluted by dioxins and furans. Arch Environ Health 2001 56: 522-528.
47. Alaluusua S, Kiviranta H, Leppäniemi A et al. Natal and neonatal teeth in relation to environmental toxicants. Pediatr Res 2002 52: 652-655.
48. Jälevik B, Norén JG. Enamel hypomineralization of permanent first molars: a morphological study and survey of possible aetiological factors. Int Paed Dent 2000 10: 278-289.
49. Leppäniemi A, Lukinmaa P-L, Alaluusua S. Nonfluoride hypomineralizations in the permanent first molars and their impact on the treatment need. Caries Res 2001 35: 36-40.
50. Weerheijm K L, Groen H J, Beetjes V E V M. Prevalence of cheese molars in eleven-year-old Dutch children. J Dent Child 2001 68: 34-37.
51. Dietrich G, Sperling S, Hetzer G. Molar incisor hypomineralisation in a group of children and adolescents living in Dresden (Germany). Eur J Paediatr Dent 2003 4: 133-137.
52. Calderara PC, Gerthoux PM, Mocarelli P et al. The prevalence of molar incisor hypomineralisation (MIH) in a group of Italian school children. Eur J Paediatr Dent 2005 6: 79-83.
53. Päpke O. PCDD/PCDF human background data for Germany, a 10-year experience. Environ Health Perspect 1998 106: 723-731.
54. Alaluusua S, Lukinmaa P-L, Vartiainen T et al. Polychlorinated dibenzo-para-dioxins and dibenzofurans via mother's milk may cause developmental defects in the child's teeth. Environ Toxicol Pharmacol 1996 1: 193-197.
55. Alaluusua S, Lukinmaa P-L, Torppa J et al. Developing teeth as biomarker of dioxin exposure. Lancet 1999 353: 206.
56. Norén K, Meironyté D. Certain organochlorine and organobromine contaminants in Swedish human milk in perspective of past 20-30 years. Chemosphere 2000 40: 1111-1123.
57. Leeuwen van FXR, Malisch R. Results of the third round of the WHO-coordinated exposure study on the levels of PCBs, PCDDs and PCDFs in human milk. Organohalogen Compounds 2002 56: 311-316.
58. Heikkinen T, Alvesalo L, Osborne RH et al. Maternal smoking and tooth formation in the foetus. II. Tooth crown size in the permanent dentition. Early Hum Dev 1994 40: 73-86.
59. Thesleff I, Nieminen P (1998). Encyclopedia of Life Sciences. London: Nature Publishing Group. In: http://www.els.net.
60. Jernvall J, Thesleff I. Reiterative signaling and patterning during mammalian tooth morphogenesis. Mech Dev 2000 92: 19-29.
61. Partanen A-M, Alaluusua S, Miettinen PJ et al. Epidermal growth factor receptor as a mediator of developmental toxicity on mouse embryonic teeth. Lab Invest 1998 78: 1473-1481.
62. Lukinmaa P-L, Sahlberg C, Leppäniemi A et al. Arrest of rat molar tooth development by lactational exposure to 2,3,7,8-tetrachlorodibenzo-p- dioxin. Toxicol Appl Pharmacol 2001 173: 38-47.
63. Partanen A-M, Kiukkonen A, Alaluusua S et al. Developmental toxicity of dioxin to mouse embryonic teeth in vitro: arrest of tooth morphogenesis involves stimulation of apoptotic program in the dental epithelium. Toxicol Appl Pharmacol 2004 194: 24-33.
64. Miettinen HM, Alaluusua S, Tuomisto J et al. Effect of TCDD on rat molar development: the critical time window. Toxicol Appl Pharmacol 2002 184: 57-66.
65. Miettinen HM, Sorvari R, Alaluusua S et al. The effect of perinatal TCDD exposure on caries susceptibility in rats. Toxicol Sci 2006 91: 568-575.
66. Hurst CH, DeVito MJ, Setzer RW. Acute administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in pregnant Long Evans rats: association of measured tissue concentrations with developmental effects. Toxicol Sci 2000 53: 411-420.
67. Peltonen E, Lukinmaa P-L, Sahlberg C et al. 7,12-Dimethyl-benz[a] anthracene interferes with the development of cultured mouse mandibular molars. Toxicol Sci 2006 92: 279-285.
68. Gao Y, Sahlberg C, Kiukkonen A et al. Lactational exposure of Han/Wistar rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin interferes with enamel maturation and retards dentin mineralization. J Dent Res 2004 83: 139-144.
69. Alaluusua S, Lukinmaa P-L, Pohjanvirta R et al. Exposure to 2,3,7,8-tetrachlorodibenzo-para-dioxin leads to defective dentin formation and pulpal perforation in rat incisor tooth. Toxicology 1993 81: 1-13.
70. McNulty WP. Toxicity and fetotoxicity of TCDD, TCDF and PCB isomers in rhesus macaques (Macaca mulatta). Environ Health Perspect 1986 60: 77-88.
71. Yasuda I, Yasuda M, Sumida H et al. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affects tooth development in rhesus monkeys. Reproduct Toxicol 2005 20: 21-30.
72. Sahlberg C, Pohjanvirta R, Gao Y et al. Expression of the mediators of dioxin toxicity, aryl hydrocarbon receptor (AHR) and the AHR nuclear translocator (ARNT), is developmentally regulated in mouse teeth. Int J Dev Biol 2002 46: 295-300.
73. Yarden Y, Sliwkowski MX. Untangling the ErbB signalling network. Nature Reviews. Mol Cell Biol 2001 2: 127-137.
74. Tuomisto J, Sewall CH, Unkila M et al. Differences in binding of epidermal growth factor to liver membranes of TCDD-resistant and TCDD-sensitive rats after a single dose of TCDD. Environ Toxicol Pharmacol 1996 1: 109-116.
75. Kiukkonen A, Sahlberg C, Partanen A-M et al. Interference by 2,3,7,8-tetrachlorodibenzo-p-dioxin with cultured mouse submandibular gland branching morphogenesis involves reduced epidermal growth factor receptor signalling. Toxicol Appl Pharmacol 2006 212: 200-211.
76. Madhular BV, Ebner K, Matsumura F et al. 2,3,7,8-Tetrachlorodibenzo-p- dioxin causes an increase in protein kinases associated with epidermal growth factor receptor in the hepatic plasma membrane. J Biochem Toxicol 1988 3: 261-277.
77. Miettinen PJ, Berger JE, Meneses J et al. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 1995 376: 337-341.
78. Kiukkonen A, Sahlberg C, Lukinmaa P-L et al. 2,3,7,8-Tetrachlorodibenzo- p-dioxin specifically reduces mRNA for the mineralization-related dentin sialophosphoprotein in cultured mouse embryonic teeth. Toxicol Appl Pharmacol 216: 399-406.
79. Hornung MW, Spitsbergen JM, Peterson RE. 2,3,7,8-Tetrachlorodibenzo-p- dioxin alters cardiovascular and craniofacial development and function in sac fry of rainbow trout (Oncorhynchus mykiss). Toxicol Sci 1999 47: 40-51.