Role of cellular compartmentation in the metabolic response to stress: Mechanistic insights from computational models

Annals of the New York Academy of Sciences

Volumn 1080, Issue , 2006, Pages 120-139

  Zhou, Lufang ^a,b   Yu, Xin ^a,b   Cabrera, Marco E ^a,b   Stanley, William C ^b,c  

^a Case Western Reserve University   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Diabetes; Exercise; Glycolysis; Ischemia; Mitochondria; NADH; Simulations

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ASPARTIC ACID; LACTIC ACID; MALIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

CITRIC ACID CYCLE; CONFERENCE PAPER; CYTOSOL; DIABETES MELLITUS; EXERCISE; GLUCOSE UTILIZATION; GLYCOGENOLYSIS; HEART MUSCLE BLOOD FLOW; HEART MUSCLE METABOLISM; HUMAN; HYDROLYSIS; INTRACELLULAR SPACE; ISCHEMIA; MATHEMATICAL MODEL; METABOLISM; MITOCHONDRION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PH; PROTEIN PHOSPHORYLATION; REPERFUSION INJURY; RESPIRATORY CHAIN; SIMULATION; STRESS; WORKLOAD;

EID: 33845628491     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1380.012     Document Type: Conference Paper

References (62)

1. STANLEY, W.C., F.A. RECCHIA & G.D. LOPASCHUK. 2005. Myocardial substrate metabolism in the normal and failing heart. Physiol. Rev. 85: 1093-1129.
2. ZHOU, L., W.C. STANLEY, G.M. SAIDEL, X. YU & M.E. CABRERA. 2005. Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD+: insights from in silico studies. J. Physiol. 569: 925-937.
3. SALEM, J.E., M.E. CABRERA, M.P. CHANDLER, et al. 2004. Step and ramp induction of myocardial ischemia: comparison of in vivo and in silico results. J. Physiol. Pharmacol. 55: 519-536.
4. SALEM, J.E., W.C. STANLEY & M.E. CABRERA. 2004. Computational studies of the effects of myocardial blood flow reductions on cardiac metabolism. Biomed. Eng. Online 3: 15.
5. CABRERA, M.E., G.M. SAIDEL & S.C. KALHAN. 1998. Modeling metabolic dynamics. From cellular processes to organ and whole body responses. Prog. Biophys. Mol. Biol. 69: 539-557.
6. GREENSTEIN, J., A.J. TANSKANEN & R. WINSLOW. 2004. Modeling the actions of [beta]-adrenergic signaling on excitation-contraction coupling processes. Ann. N. Y. Acad. Sci. 1015: 16-27.
7. MATSUOKA, S., N. SARAI, H. JO & A. NOMA. 2004. Simulation of ATP metabolism in cardiac excitation-contraction coupling. Progress Biophys. Mol. Biol. 85: 279-299.
8. MATSUOKA, S., H. JO, N. SARAI & A. NOMA. 2004. An in silico study of energy metabolism in cardiac excitation-contraction coupling. Jpn. J. Physiol. 54: 517-522.
9. SOELLER, C. & M.B. CANNELL. 2004. Analysing cardiac excitation-contraction coupling with mathematical models of local control. Prog. Biophys. Mol. Biol. 85: 141-162.
10. VAN DER VUSSE,G.J., M. VAN BILSEN, J.F. GLATZ, et al. 2002. Critical steps in cellular fatty acid uptake and utilization. Mol. Cell. Biochem. 239: 9-15.
11. CHIU, H.C., A. KOVACS, D.A. FORD, et al. 2001. A novel mouse model of lipotoxic cardiomyopathy. J. Clin. Invest. 107: 813-822.
12. HUNTER, P. & T. ARTS. 1997. Tissue remodeling with micro-structurally based material laws. Adv. Exp. Med. Biol. 430: 215-225.
13. ACHS, M.J. & D. GARFINKEL. 1977. Computer simulation of energy metabolism in anoxic perfused rat heart. Am. J. Physiol. 232: R164-R174.
14. CH'EN, F.F., R.D. VAUGHAN-JONES, K. CLARKE & D. NOBLE. 1998. Modelling myocardial ischaemia and reperfusion. Prog. Biophys. Mol. Biol. 69: 515-538.
15. CHANCE, B., D. GARFINKEL, J. HIGGINS & B. HESS. 1960. Metabolic control mechanisms. 5. A solution for the equations representing interaction between glycolysis and respiration in ascites tumor cells. J. Biol. Chem. 235: 2426-2439.
16. MCGARRY, J.D., K.F. WOELTJE, J.G. SCHROEDER, et al. 1990. Carnitine palmitoyltransferase-structure/function/regulatory relationships. Prog. Clin. Biol. Res. 321: 193-208.
17. HEINRICH, R. & S. SCHUSTER. 1998. The modelling of metabolic systems. Structure, control and optimality. Biosystems 47: 61-77.
18. KASHIWAYA, Y., K. SATO, et al. 1994. Control of glucose utilization in working perfused rat heart. J. Biol. Chem. 269: 25502-25514.
19. VOGT, A.M., H. NEF, J. SCHAPER, et al. 2002. Metabolic control analysis of anaerobic glycolysis in human hibernating myocardium replaces traditional concepts of flux control. FEBS Lett. 517: 245-250.
20. CABRERA, M., G. SAIDEL & S. KALHAN. 1998. Role of O2 in regulation of lactate dynamics during hypoxia: mathematical model and analysis. Ann. Biomed. Eng. 26: 1-27.
21. CABRERA, M., G. SAIDEL & S. KALHAN. 1999. Lactate metabolism during exercise: analysis by an integrative systems model. Am. J. Physiol. 277: R1522-R1536.
22. SALEM, J.E., G.M. SAIDEL, W.C. STANLEY & M.E. CABRERA. 2002. Mechanistic model of myocardial energy metabolism under normal and ischemic conditions. Ann. Biomed. Eng. 30: 202-216.
23. GUTH, B.D., R. SCHULZ & G. HEUSCH. 1993. Time course and mechanisms of contractile dysfunction during acute myocardial ischemia. Circulation 87: IV35-IV42.
24. BALABAN, R.S., S. BOSE, S.A. FRENCH & P.R. TERRITO. 2003. Role of calcium in metabolic signaling between cardiac sarcoplasmic reticulum and mitochondria in vitro. Am. J. Physiol. Cell. Physiol. 284: C285-C293.
25. HEINEMAN, F.W. & R.S. BALABAN. 1990. Control of mitochondrial respiration in the heart in vivo. Annu. Rev. Physiol. 52: 523-542.
26. CHANDLER, M.P., H. HUANG, T.A. MCELFRESH & W.C. STANLEY. 2002. Increased nonoxidative glycolysis despite continued fatty acid uptake during demand-induced myocardial ischemia. Am. J. Physiol. Heart Circ. Physiol. 282: H1871-H1878.
27. STANLEY, W.C., G.D. LOPASCHUK, et al. 1997. Regulation of myocardial carbohydrate metabolism under normal and ischemic conditions. Cardiovasc. Res. 33: 243-257.
28. CHANCE, B. & G.R. WILLIAMS. 1956. The respiratory chain and oxidative phosphorylation. Adv. Enzymol. Relat. Subj. Biochem. 17: 65-134.
29. HARRIS, D.A. & A.M. DAS. 1991. Control of mitochondrial ATP synthesis in the heart. Biochem. J. 280(Pt 3): 561-573.
30. KORZENIEWSKI, B., A. NOMA & S. MATSUOKA. 2005. Regulation of oxidative phosphorylation in intact mammalian heart in vivo. Biophys. Chem. 116: 145-157.
31. BALABAN, R.S. 2002. Cardiac energy metabolism homeostasis: role of cytosolic calcium. J. Mol. Cell. Cardiol. 34: 1259-1271.
32. MCCORMACK, J.G., A.P. HALESTRAP & R.M. DENTON. 1990. Role of calcium ions in regulation of mammalian intramitochondrial metabolism. Physiol. Rev. 70: 391-425.
33. CORTASSA, S., M.A. AON, E. MARBAN, et al. 2003. An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys. J. 84: 2734-2755.
34. KORZENIEWSKI, B. 2000. Regulation of ATP supply in mammalian skeletal muscle during resting state->intensive work transition. Biophys. Chem. 83: 19-34.
35. STANLEY, W.C., K.M. KIVILO, et al. 2003. Post-ischemic treatment with dipyruvyl-acetyl-glycerol decreases myocardial infarct size in the pig. Cardiovasc. Drugs Ther. 17: 209-216.
36. SHARMA, N., I.C. OKERE, D.Z. BRUNENGRABER, et al. 2005. Regulation of pyruvate dehydrogenase activity and citric acid cycle intermediates during high cardiac power generation. J. Physiol. 562: 593-603.
37. VOGT, A.M., M. POOLMAN, C. ACKERMANN, et al. 2002. Regulation of glycolytic flux in ischemic preconditioning: a study employing metabolic control analysis. J. Biol. Chem. 277: 24411-24419.
38. CABRERA, M.E., L. ZHOU, W.C. STANLEY & G.M. SAIDEL. 2005. Regulation of cardiac energetics: role of redox state and cellular compartmentation during ischemia. Ann N. Y. Acad. Sci. 1047: 259-270.
39. ZHOU, L., J.E. SALEM, G.M. SAIDEL, et al. 2005. Mechanistic model of cardiac energy metabolism predicts localization of glycolysis to cytosolic subdomain during ischemia. Am. J. Physiol. Heart Circ. Physiol. 288: H2400-H2411.
40. ZHOU, L., M.E. CABRERA, I.C. OKERE, et al. 2006. Regulation of myocardial substrate metabolism during increased energy expenditure: insights from computational studies. Am. J. Physiol. Heart Circ. Physiol. Submitted.
41. ARNOLD, H. & D. PETTE. 1968. Binding of glycolytic enzymes to structure proteins of the muscle. Eur. J. Biochem. 6: 163-171.
42. JOSHI, A. & B.O. PALSSON. 1989. Metabolic dynamics in the human red cell. Part II-Interactions with the environment. J. Theor. Biol. 141: 529-545.
43. MASTER, C.J. 1984. Interactions between glycolytic enzymes and the cytomatrix. J. Cell. Biol. 99: 222s-225s.
44. PANTLEY, G.A., S.A. MALONE, et al. 1990. Regeneration of myocardial phosphocreatine in pigs despite continued moderate ischemia. Circ. Res. 67: 1491-1493.
45. LIEDTKE, A.J. 1981. Alterations of carbohydrate and lipid metabolism in the acutely ischemic heart. Prog. Cardiovasc. Dis. 23: 321-336.
46. LLOYD, S.G., P. WANG, H. ZENG & J.C. CHATHAM. 2004. Impact of low-flow ischemia on substrate oxidation and glycolysis in the isolated perfused rat heart. Am. J. Physiol. Heart Circ. Physiol. 287: H351-H362.
47. GUTH, B.D., J.A. WISNESKI, R.A. NEESE, et al. 1990. Myocardial lactate release during ischemia in swine. Relat. Reg. Blood Flow Circ. 81: 1948-1958.
48. MYEARS, D.W., B.E. SOBEL & S.R. BERGMANN. 1987. Substrate use in ischemic and reperfused canine myocardium: quantitative considerations. Am. J. Physiol. 253: H107-H114.
49. RENSTROM, B., S.H. NELLIS & A.J. LIEDTKE. 1990. Metabolic oxidation of pyruvate and lactate during early myocardial reperfusion. Circ. Res. 66: 282-288.
50. BALABAN, R.S., H.L. KANTOR, L.A. KATZ & R.W. BRIGGS. 1986. Relation between work and phosphate metabolite in the in vivo paced mammalian heart. Science 232: 1121-1123.
51. BALABAN, R.S. 1990. Regulation of oxidative phosphorylation in the mammalian cell. Am. J. Physiol. 258: C377-C389.
52. SCHOLZ, T.D., M.R. LAUGHLIN, R.S. BALABAN, et al. 1995. Effect of substrate on mitochondrial NADH, cytosolic redox state, and phosphorylated compounds in isolated hearts. Am. J. Physiol. 268: H82-H91.
53. SCHOLZ, T.D. & R.S. BALABAN. 1994. Mitochondrial F1-ATPase activity of canine myocardium: effects of hypoxia and stimulation. Am. J. Physiol. 266: H2396-H2403.
54. TERRITO, P.R., V.K. MOOTHA, S.A. FRENCH & R.S. BALABAN. 2000. Ca(2+) activation of heart mitochondrial oxidative phosphorylation: role of the F(0)/F(1)-ATPase. Am. J. Physiol. Cell. Physiol. 278: C423-C435.
55. TERRITO, P.R., S.A. FRENCH & R.S. BALABAN. 2001. Simulation of cardiac work transitions, in vitro: effects of simultaneous Ca2+ and ATPase additions on isolated porcine heart mitochondria. Cell. Calcium 30: 19-27.
56. KORZENIEWSKI, B. 1998. Regulation of ATP supply during muscle contraction: theoretical studies. Biochem. J. 330(Pt 3): 1189-1195.
57. GIBBS, C.L. 1978. Cardiac energetics. Physiol. Rev. 58: 174-254.
58. SUGA, H. 1990. Ventricular energetics. Physiol. Rev. 70: 247-277.
59. ARNOLD, M.K.. 1992. Physiology of the Heart. Raven Press. New York.
60. LANOUE, K.F. & M.E. TISCHLER. 1974. Electrogenic characteristics of the mitochondrial glutamate-aspartate antiporter. J. Biol. Chem. 249: 7522-7528.
61. LEWANDOWSKI, E.D., X. YU, K.F. LANOUE, et al. 1997. Altered metabolite exchange between subcellular compartments in intact postischemic rabbit hearts. Circ. Res. 81: 165-175.
62. SCHOLZ, T.D., C.J. TENEYCK & B.C. SCHUTTE. 2000. Thyroid hormone regulation of the NADH shuttles in liver and cardiac mitochondria. J. Mol. Cell. Cardiol. 32: 1-10.