Endothelin-converting enzyme 2

Handbook of Proteolytic Enzymes, Second Edition: Volume 1: Aspartic and Metallo Peptidases

Volumn 1, Issue , 2004, Pages 434-436

  Ahn, Kyunghye ^a  

^a PFIZER INC   (United States)

Author keywords

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Indexed keywords

EID: 33845624008     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-079611-3.50119-1     Document Type: Chapter

References (8)

1. K. Ahn, A.M. Sisneros, S.B. Herman, S.M. Pan, D. Hupe, D. Lee, S. Nikam, X.-M. Cheng, A.M. Doherty, R.L. Schroeder, S.J. Haleen, S. Kaw, N. Emoto and M. Yanagisawa (1998) Novel selective quinazoline inhibitors of endothelin converting enzyme-1. Biochem. Biophys. Res. Commun. 243 184-190.
2. N. Emoto and M. Yanagisawa (1995) Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum. J. Biol. Chem. 270 15262-15268.
3. A. Inoue, M. Yanagisawa, S. Kimura, Y. Kasuya, T. Miyauchi, K. Goto and T. Masaki (1989) The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc. Natl. Acad. Sci. USA 86 2863-2867.
4. M.N. Lorenzo, R.Y. Khan, Y. Wang, S.C. Tai, G.C. Chan, A.H. Cheung and P.A. Marsden (2001) Human endothelin converting enzyme-2 (ECE2): characterization of mRNA species and chromosomal localization. Biochim. Biophys. Acta 1522 46-52.
5. K. Ohnaka, R. Takayanagi, M. Nishikawa, M. Haji and H. Nawata (1993) Purification and characterization of a phosphoramidon-sensitive endothelin-converting enzyme in porcine aortic endothelium. J. Biol. Chem. 268 26759-26766.
6. M. Takahashi, Y. Matsushita, Y. Iijima and K. Tanzawa (1993) Purification and characterization of endothelin-converting enzyme from rat lung. J. Biol. Chem. 268 21394-21398.
7. H. Yanagisawa, R.E. Hammer, J.A. Richardson, N. Emoto, S.C. Williams, S. Takeda, D.E. Clouthier and M. Yanagisawa (2000) Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development. J. Clin. Invest. 105 1373-1382.
8. D. Xu, N. Emoto, A. Giaid, C. Slaughter, S. Kaw, D. deWit and M. Yanagisawa (1994) ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell 78 473-485.