A multivalent peptide library approach identifies a novel Shiga toxin inhibitor that induces aberrant cellular transport of the toxin

FASEB Journal

Volumn 20, Issue 14, 2006, Pages

  Nishikawa, Kiyotaka ^a,b   Watanabe, Miho ^a   Kita, Eiji ^c   Igai, Katsura ^a,b   Omata, Kazumi ^a   Yaffe, Michael B ^d   Natori, Yasuhiro ^a  

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c NARA MEDICAL UNIVERSITY   (Japan)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Globotriaosylceramide; Multivalent interaction; Retrograde transport; Shiga toxin producing E. coli infection; Therapeutic agent

Indexed keywords

PEPTIDE LIBRARY; SHIGA TOXIN; VEROTOXIN 2; PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CELL TRANSPORT; CYTOTOXICITY; ENDOPLASMIC RETICULUM; ESCHERICHIA COLI; GOLGI COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CERCOPITHECUS; CHEMISTRY; DRUG ANTAGONISM; ENTEROBACTER INFECTION; FEMALE; METABOLISM; MUTATION; PROTEIN CONFORMATION; VERO CELL;

ESCHERICHIA COLI;

AMINO ACID SEQUENCE; ANIMALS; CERCOPITHECUS AETHIOPS; ENDOPLASMIC RETICULUM; ESCHERICHIA COLI INFECTIONS; FEMALE; GOLGI APPARATUS; MICE; MICE, INBRED C57BL; MUTATION; PEPTIDE LIBRARY; PEPTIDES; PROTEIN CONFORMATION; SHIGA TOXIN; VERO CELLS;

EID: 33845620960     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-6572fje     Document Type: Article

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