Safety pharmacology and prolongation of the QT interval

Journal of Electrocardiology

Volumn 40, Issue 1 SUPPL., 2007, Pages

  Cavero, Icilio ^a   Yan, Gan Xin ^b   Lux, Robert ^c   Steinhoff, Uwe ^d  

^a Lankenau Institute for Medical Research ^*

^b LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

^c UNIVERSITY OF UTAH   (United States)

^d PHYSIKALISCH TECHNISCHE BUNDESANSTALT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CISAPRIDE; CLARITHROMYCIN; ERYTHROMYCIN; ISOPRENALINE; SOTALOL; SPARFLOXACIN;

ARTICLE; DRUG SAFETY; ELECTROCARDIOGRAM; HEART PROARRHYTHMIA; HUMAN; INTERMETHOD COMPARISON; MAGNETOCARDIOGRAPHY; MEDICAL SOCIETY; NONHUMAN; PREDICTION; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION;

EID: 33845617692     PISSN: 00220736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jelectrocard.2006.10.035     Document Type: Note

References (18)

1. Roden D.M. Drug-induced prolongation of QT interval. N Engl J Med 350 (2004) 1013
2. International Conference on Harmonisation of technical requirements for registration of pharmaceuticals for human use. ICH harmonized tripartite guideline: The non-clinical evaluation of the potential for delayed ventricular repolarization (QT interval prolongation) by human pharmaceuticals. S7B. (2005): http://www.ich.org/LOB/media/MEDIA2192.pdf.
3. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. ICH harmonized tripartite guideline: the clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs. E14 (2005): http://www.ich.org/LOB/media/MEDIA1476.pdf.
4. Cavero I., and Crumb W. The use of electrocardiograms in clinical trials: a public discussion of the proposed ICH E14 regulatory guidance. April 11-12, 2005, Bethesda, MD, USA. Expert Opin Drug Saf 4 (2005) 795
5. Liu T., Brown B., Wu Y., Antzelevitch C., Kowey P.R., and Yan G.X. Blinded validation of the arterially isolated perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias. Heart Rhythm 3 (2006) 948
6. Yan G.X., Wu Y., Liu T., et al. Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long QT syndrome: direct evidence from intracellular recordings in the intact left ventricular wall. Circulation 1003 (2001) 2851
7. Hondeghem L.M. TRIad: foundation for proarrhythmia (triangulation, reverse use dependence and instability). Novartis Found Symp 266 (2005) 235
8. Valentin J.P., Hoffmann P., De Clerck F., Hammond T.G., and Hondeghem L. Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs. J Pharmacol Toxicol Methods 49 (2004) 171
9. Hondeghem L.M., Lu H.R., van Rossem K., and De Clerck F. Detection of proarrhythmia in the female rabbit heart: blinded validation. J Cardiovasc Electrophysiol 14 (2003) 287
10. Hondeghem L.M., and Hoffmann P. Blinded test in isolated female rabbit heart reliably identifies action potential duration prolongation and proarrhythmic drugs: importance of triangulation, reverse use dependence, and instability. J Cardiovasc Pharmacol 41 (2003) 14
11. Fenici R., Brisinda D., and Meloni A.M. Clinical application of magnetocardiography. Expert Rev Mol Diagn 5 (2005) 291
12. Brazdeikis A., Chu C.W., Cherukuri P., Litovsky S., and Naghavi M. Changes in magnetocardiogram patterns of infarcted-reperfused myocardium after injection of superparamagnetic contrast media. Neurol Clin Neurophysiol 2004 (2004) 16
13. Steinhoff U., Knappe-Grueneberg S., Schnabel A., et al. Magnetocardiography for pharmacology safety studies requiring high patient throughput and reliability. J Electrocardiol 37 Suppl (2004) 187
14. Brisinda D., Caristo M.E., and Fenici R. Contactless magnetocardiographic mapping in anesthetized Wistar rats: evidence of age-related changes of cardiac electrical activity. Am J Physiol Heart Circ Physiol 291 (2006) H368
15. Steinhoff U., Wilhelm C., Wiekhorst F., et al. Contactless magnetocardiographic characterization of knock-out mice. Folia Cardiol 12 (2005) 396
16. Wiekhorst F., Jurgons R., Eberbeck D., et al. SQUID system with integrated superconducting shield for monitoring of drug targeting with magnetic nanoparticles in animals. Biomed Tech 50 (2005) 609
17. Fuller M.S., Sandor G., et al. Estimates of repolarization and its dispersion from electrocardiographic measurements: direct epicardial assessment in the canine heart. J Electrocardiol 33 (2000) 171
18. Fuller M.S., Sandor G., et al. Estimates of repolarization dispersion from electrocardiographic measurements. Circulation 102 (2000) 685