Isoflurane and propofol have similar effects on spinal neuronal windup at concentrations that block movement

Anesthesia and Analgesia

Volumn 103, Issue 6, 2006, Pages 1453-1458

  Ng, Kevin P ^a   Antognini, Joseph F ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOFLURANE; PANCURONIUM; PROPOFOL;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ELECTROSTIMULATION; LUMBAR SPINE; MALE; MINIMUM LUNG ALVEOLUS CONCENTRATION; NERVE BLOCK; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD NERVE CELL;

ANESTHETICS; ANIMALS; ISOFLURANE; MALE; NERVE FIBERS, MYELINATED; NEURONS; PROPOFOL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD;

EID: 33845599551     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ane.0000247732.33602.f5     Document Type: Article

References (22)

1. Jurd R, Arras M, Lambert S, et al. General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit. FASEB J 2003;17:250-2.
2. Krasowski MD, Harrison NL. General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci 1999;55:1278-303.
3. Yamakura T, Harris RA. Effects of gaseous anesthetics nitrous oxide and xenon on ligand-gated ion channels. Comparison with isoflurane and ethanol. Anesthesiology 2000;93:1095-101.
4. Urch CE, Rahman W, Dickenson AH. Electrophysiological studies on the role of the NMDA receptor in nociception in the developing rat spinal cord. Brain Res Dev Brain Res 2001;126:81-9.
5. Herrero JF, Laird JM, Lopez-Garcia JA. Wind-up of spinal cord neurones and pain sensation: much ado about something? Prog Neurobiol 2000;61:169-203.
6. Matute E, Rivera-Arconada I, Lopez-Garcia JA. Effects of propofol and sevoflurane on the excitability of rat spinal motoneurones and nociceptive reflexes in vitro. Br J Anaesth 2004;93:422-7.
7. Solt K, Eger EI II, Raines DE. Differential modulation of human N-methyl-D-aspartate receptors by structurally diverse general anesthetics. Anesth Analg 2006;102:1407-11.
8. Cuellar JM, Dutton RC, Antognini JF, Carstens E. Differential effects of halothane and isoflurane on lumbar dorsal horn neuronal windup and excitability. Br J Anaesth 2005;94:35-48.
9. Jinks SL, Antognini JF, Dutton RC, et al. Isoflurane depresses windup of C-fiber-evoked limb withdrawal with variable effects on nociceptive lumbar spinal neurons in rats. Anesth Analg 2004;99:1413-19.
10. Jinks SL, Carstens E, Antognini JF. Isoflurane differentially modulates medullary ON and OFF neurons while suppressing hindlimb motor withdrawals. Anesthesiology 2004;100:1224-34.
11. Orth M, Barter L, Dominguez C, et al. Halothane and propofol differentially affect electroencephalographic responses to noxious stimulation. Br J Anaesth 2005;95:477-84.
12. Mitsuyo T, Dutton RC, Antognini JF, Carstens E. Differential effects of halothane and isoflurane on windup of dorsal horn neurons selected in unanesthetized decerebrated rats. Anesth Analg 2006;103:753-60.
13. Yamauchi M, Sekiyama H, Shimada SG, Collins JG. Halothane suppression of spinal sensory neuronal responses to noxious peripheral stimuli is mediated, in part, by both GABA(A) and glycine receptor systems. Anesthesiology 2002;97:412-17.
14. Chapman V, Dickenson AH. The effect of intrathecal administration of RP67580, a potent neurokinin 1 antagonist on nociceptive transmission in the rat spinal cord. Neurosci Lett 1993;157:149-52.
15. Woolf CJ. C-primary afferent fiber mediated inhibitions in the dorsal horn of the decerebrate-spinal rat. Exp Brain Res 1983;51:283-90.
16. Reeve AJ, Dickenson AH, Kerr NC. Spinal effects of bicuculline: modulation of an allodynia-like state by an A1-receptor agonist, morphine, and an NMDA-receptor antagonist. J Neurophysiol 1998;79:1494-507.
17. Seagrove LC, Suzuki R, Dickenson AH. Electrophysiological characterisations of rat lamina I dorsal horn neurones and the involvement of excitatory amino acid receptors. Pain 2004;108:76-87.
18. Dutton RC, Laster MJ, Xing Y, et al. Do N-methyl-D-aspartate receptors mediate the capacity of inhaled anesthetics to suppress the temporal summation that contributes to minimum alveolar concentration? Anesth Analg 2006;102:1412-18.
19. Eger EI II, Liao M, Laster MJ, et al. Contrasting roles of the N-methyl-D-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics. Anesth Analg 2006;102:1397-406.
20. Roth D, Petersen-Felix S, Bak P, et al. Analgesic effect in humans of subanaesthetic isoflurane concentrations evaluated by evoked potentials. Br J Anaesth 1996;76:38-42.
21. Petersen-Felix S, Arendt-Nielsen L, Bak P, et al. Analgesic effect in humans of subanaesthetic isoflurane concentrations evaluated by experimentally induced pain. Br J Anaesth 1995;75:55-60.
22. Frolich MA, Price DD, Robinson ME, et al. The effect of propofol on thermal pain perception. Anesth Analg 2005;100:481-6.