Aetiology of preterm labour: Bacterial vaginosis

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 113, Issue SUPPL. 3, 2006, Pages 46-51

  Guaschino, S ^a,b   De Seta, F ^a   Piccoli, M ^a   Maso, G ^a   Alberico, S ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

^b INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

Author keywords

Antibiotics; Bacterial vaginosis; Immune response; Preterm birth; Vaginal pH

Indexed keywords

ANTIBIOTIC AGENT; CLINDAMYCIN; CLOTRIMAZOLE; ERYTHROMYCIN; METRONIDAZOLE;

ANAEROBIC BACTERIUM; BACTERIAL COLONIZATION; CLINICAL FEATURE; CLINICAL PRACTICE; CLINICAL TRIAL; CYTOKINE PRODUCTION; DIAGNOSTIC TEST; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; ENDOMETRITIS; GENITAL TRACT INFECTION; GEOGRAPHIC DISTRIBUTION; HOST PATHOGEN INTERACTION; HUMAN; IMMUNE RESPONSE; INFECTION RISK; LACTOBACILLUS; LOW BIRTH WEIGHT; META ANALYSIS; PATHOGENESIS; PELVIC INFLAMMATORY DISEASE; PREGNANCY; PREGNANCY OUTCOME; PREMATURE LABOR; PREVALENCE; PRIORITY JOURNAL; RACE DIFFERENCE; REVIEW; SCREENING TEST; SYSTEMATIC REVIEW; VAGINITIS;

FEMALE; HUMANS; IMMUNITY, MUCOSAL; OBSTETRIC LABOR, PREMATURE; PREGNANCY; RISK FACTORS; VAGINOSIS, BACTERIAL;

EID: 33845598207     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.2006.01122.x     Document Type: Review

References (33)

1. Amsel R, Totten PA, Spiegel CA, Chen KC, Eschenbach D, Holmes KK. Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med 1983;74:14-22.
2. Spiegel CA, Amsel R, Holmes KK. Diagnosis of bacterial vaginosis by direct gram stain of vaginal fluid. J Clin Microbiol 1983;18:170-7.
3. Nugent RP, Krohn MA, Hillier SL. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol 1991;29:297-301.
4. Leitich H, Bodner-Adler B, Brunbauer M, Kaider A, Egarter C, Husslein P. Bacterial vaginosis as a risk factor for preterm delivery: a meta-analysis. Am J Obstet Gynecol 2003;189:139-47.
5. Klebanoff MA, Hillier SL, Nugent RP, MacPherson CA, Hauth JC, Carey JC, et al. Is bacterial vaginosis a stronger risk factor for preterm birth when it is diagnosed earlier in gestation? Am J Obstet Gynecol 2005;192:470-7.
6. Hillier SL, Nugent RP, Eschenbach DA, Krohn MA, Gibbs RS, Martin DH, et al. for the Vaginal Infections and Prematurity Study Group. Association between bacterial vaginosis and preterm delivery of a low birth weight infant. N Engl J Med 1995;333:1737-42.
7. Cauci S, Thorsen P, Schendel D, Bremmelgaard A, Quadrifoglio F, Guaschino S. Determination of immunoglobulin A against Gardnerella vaginalis hemolysin, sialidase and prolidase activities in vaginal fluid: implications for adverse pregnancy outcome. J Clin Microbiol 2003;41:435-8.
8. Cauci S, McGregor J, Thorsen P, Grove J, Guaschino S. Combination of vaginal pH with vaginal sialidase and prolidase activities for prediction of low birth weight and preterm birth. Am J Obstet Gynecol 2005;192:489-96.
9. Cauci S, Guaschino S, De Aloysio D, Driussi S, De Santo D, Penacchioni P, Quadrifoglio F. Interrelationship of interleukin-8 with interleukin-1 beta and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women. Mol Hum Reprod 2003;9:53-8.
10. Cauci S, Driussi S, Guaschino S, Isola M, Quadrifoglio F. Correlation of local interleukin-1 beta levels with specific IgA response against Gardnerella vaginalis cytolysin in women with bacterial vaginosis. Am J Reprod Immunol 2002;47:257-64.
11. Genc M, Witkin SS, Delaney ML, Paraskevas LR, Tuomala RE, Norwitz ER, et al. A disproportionate increase in IL-1 beta over IL-1ra in the cervicovaginal secretions of pregnant women with altered vaginal microflora correlates with preterm birth. Am J Obstet Gynecol 2004;190:1191-7.
12. Simhan HN, Caritis SN, Krohn MA, de Tajada BM, Landers DV, Hillier SL. Decreased cervical proinflammatory cytokines permit subsequent upper genital tract infection during pregnancy. Am J Obstet Gynecol 2003;189:560-7.
13. Romero R, Chaiworapongsa T, Kuivaniemi H, Tromp G. Bacterial vaginosis, the inflammatory response and the risk of preterm birth: a role for genetic epidemiology in the prevention of preterm birth. Am J Obstet Gynecol 2004;190:1509-19.
14. Macones GA, Parry S, Elkousy M, Clothier B, Ural SH, Strauss JF. A polymorphism in the promoter region of TNF and bacterial vaginosis: preliminary evidence of gene environment interaction in the etiology of spontaneous preterm birth. Am J Obstet Gynecol 2004;190:1504-8.
15. Guaschino S, Ricci E, Franchi M, Frate GD, Tibaldi C, Santo DD, et al. Treatment of asymptomatic bacterial vaginosis to prevent pre-term delivery: a randomised trial. Eur J Obstet Gynecol Reprod Biol 2003;110:149-52.
16. Morales WJ, Schorr S, Albritton J. Effect of metronidazole in patients with preterm birth in preceding pregnancy and bacterial vaginosis: a placebo-controlled, double-blind study. Am J Obstet Gynecol 1994;171:345-7.
17. McGregor JA, French JI, Jones W, Milligan K, McKinney PJ, Patterson E, et al. Bacterial vaginosis is associated with prematurity and vaginal fluid mucinase and sialidase: results of a controlled trial of topical clindamycin cream. Am J Obstet Gynecol 1994;170:1048-59.
18. Hauth JC, Goldenberg RL, Andrews WW, DuBard MB, Copper RL. Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis. N Engl J Med 1995;333:1732-6.
19. Joesoef MR, Hillier SL, Wiknjosastro G, Sumampouw H, Linnan M, Norojono W, et al. Intravaginal clindamycin treatment for bacterial vaginosis: effects on preterm delivery and low birth weight. Am J Obstet Gynecol 1995;173:1527-31.
20. McDonald HM, O'Loughlin JA, Vigneswaran R, Jolley PT, Harvey JA, Bof A, et al. Impact of metronidazole therapy on preterm birth in women with bacterial vaginosis flora (Gardnerella vaginalis): a randomised, placebo controlled trial. Br J Obstet Gynaecol 1997;104:1391-7.
21. Carey JC, Klebanoff MA, Hauth JC, Hillier SL, Thom EA, Ernest JM, et al. Metronidazole to prevent preterm delivery in pregnant women with asymptomatic bacterial vaginosis. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. N Engl J Med 2000;342:534-40.
22. Kekki M, Kurki T, Pelkonen J, Kurkinen-Raty M, Cacciatore B, Paavonen J. Vaginal clindamycin in preventing preterm birth and peripartal infections in asymptomatic women with bacterial vaginosis: a randomized, controlled trial. Obstet Gynecol 2001;97:643-8.
23. Kurkinen-Raty M, Vuopala S, Koskela M, Kekki M, Kurki T, Paavonen J. A randomised controlled trial of vaginal clindamycin for early pregnancy bacterial vaginosis. BJOG 2000;107:1427-32.
24. Lamont RF, Duncan SL, Mandal D, Bassett P. Intravaginal clindamycin to reduce preterm birth in women with abnormal genital tract. Obstet Gynecol 2003;101:516-22.
25. Ugwumadu A, Manyonda I, Reid F, Hay P. Effect of early oral clindamycin on late miscarriage and preterm delivery in asymptomatic woman with abnormal vaginal flora and bacterial vaginosis: a randomize controlled trial. Lancet 2003;361:983-8.
26. Kiss H, Petricevic L, Husslein P. Prospective randomised controlled trial of an infection screening programme to reduce the rate of preterm delivery. Br Med J 2004;329:371.
27. Mc Donald H, Brocklehurst P, Parsons J. Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database Syst Rev 2005;25:CD000262.
28. Riggs MA, Klebanoff MA. Treatment of vaginal infections to prevent preterm birth: a meta-analysis. Clin Obstet Gynecol 2004;47:796-807.
29. Guise JM, Mahon SM, Aickin M, Helfand M, Peipert JF, Westhoff C. Screening for bacterial vaginosis in pregnancy. Am J Prev Med 2001;20:62-72.
30. Varma R, Gupta JK. Antibiotic treatment of bacterial vaginosis in pregnancy: multiple meta-analyses and dilemmas in interpretation. Eur J Obstet Gynecol Reprod Biol 2006;124:10-14.
31. Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines 2002: Management of Patients Who Have Vaginal Infections. [http://www.cdc.gov/STD/treatment/5-2002TG. htm#BacterialVaginosis]. Accessed 17 October 2006.
32. Beigi RH, Austin MN, Meyn LA, Krohn MA, Hillier SL. Antimicrobial resistance associated with the treatment of bacterial vaginosis. Am J Obstet Gynecol 2004;191:1124-9.
33. Larsson PG, Fahraeus L, Carlsson B, Jakobsson T, Forsum U.; Premature study group of the Southeast Health Care Region of Sweden. Late miscarriage and preterm birth after treatment with clindamycin: a randomised consent design study according to Zelen. BJOG 2006;113:629-37.