Automated digital light modulation microscope (DLMM) for living cell array analysis: Pattern recognition and spatial alignment

Proceedings of the First IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics, 2006, BioRob 2006

Volumn 2006, Issue , 2006, Pages 977-981

  Chao, Shih Hui ^b   Ren, Timothy T H ^b   Gales, Steven A ^b   Holl, Mark R ^b   McQuaide, Sarah C ^b   Meldrum, Deirdre R ^a,b  

^a IEEE

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Digital light modulation microscope; DMD; High content cell screening; Large scale cell array; Microfluidics

Indexed keywords

ALGORITHMS; FLUIDICS; IMAGING TECHNIQUES; LIGHT MODULATION; PATTERN RECOGNITION;

DIGITAL LIGHT MODULATION MICROSCOPE; HIGH CONTENT CELL SCREENING; LARGE SCALE CELL ARRAY; MICROFLUIDICS;

CELLULAR ARRAYS;

EID: 33845565703     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/BIOROB.2006.1639218     Document Type: Conference Paper

References (13)

1. Mary E. Lidstrom and Deirdre R. Meldrum, "Life-on-a-Chip," Nature Reviews Microbiology vol. 1, no. 2, pp. 158-164, 2003.
2. V. C. Abraham, D. L. Taylor, and J. R. Haskins, "High content screening applied to large-scale cell biology," Trends in Biotechnology, vol. 22, pp. 15-22, 2004.
3. S. Bajaj, J. B. Welsh, R. C. Leif, and J. H. Price, "Ultra-rare- event detection performance of a custom scanning cytometer on a model preparation of fetal nRBCs," Cytometry, vol. 39, pp. 285-294, 2000.
4. L. S. Hibbard, J. S. Mccasland, J. E. Brunstrom, and A. L. Pearlman, "Automated recognition and mapping of immunolabelled neurons in the developing brain," Journal of Microscopy-Oxford, vol. 183, pp. 241-256, 1996.
5. P. Perner, H. Perner, and B. Muller, "Mining knowledge for HEp-2 cell image classification," Artificial Intelligence in Medicine, vol. 26, pp. 161-173, 2002.
6. D. G. Anderson, S. Levenberg, and R. Langer, "Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells," Nature Biotechnology, vol. 22, pp. 863-866, 2004.
7. Z. E. Perlman, M. D. Slack, Y. Feng, T. J. Mitchison, L. F. Wu, and S. J. Altschuler, "Multidimensional drug profiling by automated microscopy," Science, vol. 306, pp. 1194-1198, 2004.
8. L. J. Hornbeck, "The DMD (TM) projection display chip: A MEMS-based technology," Mrs Bulletin, vol. 26, pp. 325-327, 2001.
9. P. J. Verveer, Q. S. Hanley, P. W. Verbeek, L. J. Van Vliet, and T. M. Jovin, "Theory of confocal fluorescence imaging in the programmable array microscope (PAM)," Journal of Microscopy, vol. 189, pp. 192-8, 1998.
10. Q. S. Hanley, P. J. Verveer, M. J. Gemkow, D. Arndt Jovin, and T. M. Jovin, "An optical sectioning programmable array microscope implemented with a digital micromirror device," Journal of Microscopy, vol. 196, pp. 317-31, 1999.
11. Q. S. Hanley, P. J. Verveer, and T. M. Jovin, "Optical sectioning fluorescence spectroscopy in a programmable array microscope," Applied Spectroscopy, vol. 52, pp. 783-9, 1998.
12. S. C. McQuaide, M. R. Holl, L. Burgess, T. Molter, J. Dragavon, A. C. Young, T. Strovas, J. Anderson, A. Jen, B. Karlsgodt, M. Lidstrom, and R. D. Meldrum, "A Living Cell Array (LCA) for Multiparameter Cell Metabolism Studies," presented at IEEE / RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics, Pisa, Italy, 2006.
13. R. M. Haralick and L. G. Shapiro, Computer and robot vision. Reading, Mass.: Addison-Wesley Pub. Co, 1992.