Diagnosis of syphilis: Clinical and laboratory problems;Syphilisdiagnostik: Klinische und labormedizinische problematik

JDDG - Journal of the German Society of Dermatology

Volumn 4, Issue 12, 2006, Pages 1058-1075

  Lautenschlager, Stephan ^a  

^a TRIEMLI HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL FEATURE; CONGENITAL SYPHILIS; DIAGNOSTIC APPROACH ROUTE; DIAGNOSTIC TEST; DIFFERENTIAL DIAGNOSIS; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; GENITAL ULCER; HUMAN; LABORATORY DIAGNOSIS; NONHUMAN; POLYMERASE CHAIN REACTION; REVIEW; SECONDARY SYPHILIS; SENSITIVITY AND SPECIFICITY; SERODIAGNOSIS; SYMPTOMATOLOGY; SYPHILIS; TREPONEMA PALLIDUM; VENEREAL DISEASE REACTION TEST;

ADULT; ANUS DISEASES; CHANCRE; DIAGNOSIS, DIFFERENTIAL; FEMALE; HIV INFECTIONS; HOMOSEXUALITY, MALE; HUMANS; INFANT, NEWBORN; MALE; MOUTH DISEASES; NEUROSYPHILIS; ORAL ULCER; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PROCTOSCOPY; SEXUAL BEHAVIOR; SYPHILIS; SYPHILIS SERODIAGNOSIS; SYPHILIS, CONGENITAL; TIME FACTORS;

EID: 33845564298     PISSN: 16100379     EISSN: 16100387     Source Type: Journal    
DOI: 10.1111/j.1610-0387.2006.06072.x     Document Type: Review

References (65)

1. Nicoll A, Hamers FF. Are trends in HIV, gonorrhoea, and syphilis worsening in western Europe? BMJ 2002; 324: 1324-1327.
2. RKI. Syphilis: Zur Situation in Deutschland 2004. Epidemiol Bull 2005; 26: 221-225.
3. Hamouda O, Marcus U. Syphilis auf dem Vormarsch. Neues Meldeverfahren nach dem Infektionsschutzgesetz. Hautarzt 2005; 56: 124-132.
4. Lautenschlager S. Sexually transmitted infections in Switzerland: return of the classics. Dermatology 2005; 210: 134-142.
5. Fenton KA, Lowndes CM. Recent trends in the epidemiology of sexually transmitted infections in the European Union. Sex Transm Infect 2004; 80: 255-263.
6. Schöfer H. Syphilis. Klinik der Treponema-pallidum-Infektion. Hautarzt 2004; 55: 112-119.
7. Schöfer H, Brockmeyer NH, Hagedorn H-J, Hamouda O, Handrick W, Krause W, Marcus U, Münstermann D, Petry KU, Prange H, Potthoff A, Gross G. Syphilis. Leitlinie der Deutschen STD Gesellschaft zur Diagnostik und Therapie der Syphilis. J Dtsch Dermatol Ges 2006; 2: 160-177.
8. CDC. Sexually transmitted diseases treatment guidelines 2002. Centers for Disease Control and Prevention. MMWR 2002; 51: 1-78.
9. Musher DM. Early syphilis. In: Holmes KK, Sparling PF, Mardh P, Lemon SM, Stamm WE, Piot P, Wasserheit JN. Editors. Sexually Transmitted Diseases. New York: McGraw-Hill, 1999: 479-485.
10. Lynn WA, Lightman S. Syphilis and HIV: a dangerous combination. Lancet Infect Dis 2004; 4: 456-466.
11. DiCarlo RP, Martin DH. The clinical diagnosis of genital ulcer disease in men. Clin Infect Dis 1997; 25: 292-298.
12. Lacey HB, Higgins SP, Graham D. An outbreak of early syphilis: cases from North Manchester General Hospital. Sex Transm Infect 2001; 77: 311-313.
13. Hourihan M, Wheeler H, Houghton R, Goh BT. Lessons from the syphilis outbreak in homosexual men in east London. Sex Transm Infect 2004; 80: 509-511.
14. Lautenschlager S, Eichmann A. The heterogeneous clinical spectrum of genital herpes. Dermatology 2001; 202: 211-219.
15. Chapel TA, Prasad P, Chapel J, Lekas N. Extragenital syphilitic chancres. J Am Acad Dermatol 1985; 13: 582-584.
16. Haustein UF, Pfeil B, Zschiesche A. Analyse der von 1983-1991 an der Universitäts-Hautklinik Leipzig beobachteten Syphilisfälle. Hautarzt 1993; 44: 23-29.
17. Alam F, Argiriadou AS, Hodgson TA, Kumar N, Porter SR. Primary syphilis remains a cause of oral ulceration. Br Dent J 2000; 189: 352-354.
18. Donofrio P. Unusual location of syphilitic chancre: case report. Genitourin Med 1986; 62: 59-60.
19. Weber B. Ein Fall von syphilitischem Primäraffekt am Lid. Klin Monatsbl Augenheilkd 1982; 180: 565-566.
20. Lautenschlager S, Schwarzkopf S, Borelli S. Presternal indurated ulceration: primary syphilis. Dermatology 2006; 212: 200-202.
21. Fournier A. Treatment and prophylaxis of syphilis. London: Rebman Limited, 1906.
22. Kumar B, Gupta S, Muralidhar S. Mucocutaneous manifestations of secondary syphilis in north Indian patients: a changing scenario? J Dermatol 2001; 28: 137-144.
23. Martin DH, Mroczkowski TF. Dermatologic manifestations of sexually transmitted diseases other than HIV. Infect Dis Clin North Am 1994; 8: 533-582.
24. Carbia SG, Lagodin C, Abbruzzese M, Sevinsky L, Casco R, Casas J, Woscoff A. Lichenoid secondary syphilis. Int J Dermatol 1999; 38: 53-55.
25. Papini M, Bettacchi A, Guiducci A. Nodular secondary syphilis. Br J Dermatol 1998; 138: 704-705.
26. Chapel TA. The signs and symptoms of secondary syphilis. Sex Transm Dis 1980; 7: 161-164.
27. Little JW. Syphilis: an update. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005; 100: 3-9.
28. Stepanova A, Marsch WC. Plaques opalines. Eine seltene Manifestation der Sekundärsyphilis an der Mundschleimhaut. Hautarzt. In press.
29. Pandhi RK, Singh N, Ramam M. Secondary syphilis: a clinicopathologic study. Int J Dermatol 1995; 34: 240-243.
30. Engelkens HJ, ten Kate FJ, Vuzevski VD, van der Sluis JJ, Stolz E. Primary and secondary syphilis: a histopathological study. Int J STD AIDS 1991; 2: 280-284.
31. Körber A, Dissemond J, Lehnen M, Franckson T, Grabbe S, Esser S. Syphilis bei HIV-Koinfektion. J Dtsch Dermatol Ges 2004; 2: 833-840.
32. Rompalo AM, Joesoef MR, O'Donnell JA, Augenbraun M, Brady W, Radolf JD, Johnson R, Rolfs RT. Clinical manifestations of early syphilis by HIV status and gender: results of the syphilis and HIV study. Sex Transm Dis 2001; 28: 158-165.
33. Inamadar AC, Palit A. Perforating chancre: any cause-effect relation with HIV infection? Sex Transm Infect 2003; 79: 262.
34. Wappner D, Carbia S, Gioseffi L, Schroh R, Losso MH. Diagnosis: malignant syphilis. Clin Infect Dis 1997; 25: 1343, 1447.
35. Don PC, Rubinstein R, Christie S. Malignant syphilis (lues maligna) and concurrent infection with HIV. Int J Dermatol 1995; 34: 403-407.
36. Schöfer H, Imhof M, Thoma-Greber E, Brockmeyer NH, Hartmann M, Gerken G, Pees HW, Rasokat H, Hartmann H, Sadri I, Emminger C, Stellbrink HJ, Baumgarten R, Plettenberg A. Active syphilis in HIV infection: a multicentre retrospective survey. The German AIDS Study Group (GASG). Genitourin Med 1996; 72: 176-181.
37. Egglestone SI, Turner AJ. Serological diagnosis of syphilis. PHLS Syphilis Serology Working Group. Commun Dis Public Health 2000; 3: 158-162.
38. Larsen SA, Steiner BM, Rudolph AH. Laboratory diagnosis and interpretation of tests for syphilis. Clin Microbiol Rev 1995; 8: 1-21.
39. Goh BT, Voorst Vader PC. European guideline for the management of syphilis. Int J STD AIDS 2001; 12 Suppl 3: 14-26.
40. Cummings MC, Lukehart SA, Marra C, Smith BL, Shaffer J, Demeo LR, Castro C, McCormack WM. Comparison of methods for the detection of treponema pallidum in lesions of early syphilis. Sex Transm Dis 1996; 23: 366-369.
41. Palmer HM, Higgins SP, Herring AJ, Kingston MA. Use of PCR in the diagnosis of early syphilis in the United Kingdom. Sex Transm Infect 2003; 79: 479-483.
42. Wheeler HL, Agarwal S, Goh BT. Dark ground microscopy and treponemal serological tests in the diagnosis of early syphilis. Sex Transm Infect 2004; 80: 411-414.
43. Rogstad KE, Simms I, Fenton KA, Edwards S, Fisher M, Carne CA. Screening, diagnosis and management of early syphilis in genitourinary medicine clinics in the UK. Int J STD AIDS 2005; 16: 348-352.
44. Liu H, Rodes B, Chen CY, Steiner B. New tests for syphilis: rational design of a PCR method for detection of Treponema pallidum in clinical specimens using unique regions of the DNA polymerase I gene. J Clin Microbiol 2001; 39: 1941-1946.
45. Brockmeyer, N.H. Syphilis. In: Petzoldt D, Gross G, editors. Diagnostik und Therapie sexuell übertragbarer Krankheiten. Berlin: Springer Verlag, 2001: 101-111.
46. Wicher K, Horowitz HW, Wicher V. Laboratory methods of diagnosis of syphilis for the beginning of the third millennium. Microbes Infect 1999; 1: 1035-1049.
47. Young H. Syphilis. Serology. Dermatol Clin 1998; 16: 691-698.
48. Heise H. Aktuelles zur Syphilistherapie und zur serologischen Kontrolle. Hautarzt 2004; 55: 1087-1089.
49. Hook EW, III, Marra CM. Acquired syphilis in adults. N Engl J Med 1992; 326: 1060-1069.
50. Nandwani R, Evans DT. Are you sure it's syphilis? A review of false positive serology. Int J STD AIDS 1995; 6: 241-248.
51. Kuznetsov AV, Burgdorf WH, Prinz JC. Latent syphilis confirmed by polymerase chain reaction in 2 HIV-positive patients with inconclusive serologic test results. Arch Dermatol 2005; 141: 1169-1170.
52. Smith G, Holman RP. The prozone phenomenon with syphilis and HIV-1 co-infection. South Med J 2004; 97: 379-382.
53. Taniguchi S, Osato K, Hamada T. The prozone phenomenon in secondary syphilis. Acta Derm Venereol 1995; 75: 153-154.
54. Young H. Guidelines for serological testing for syphilis. Sex Transm Infect 2000; 76: 403-405.
55. Koff AB, Rosen T. Nonvenereal treponematoses: yaws, endemic syphilis, and pinta. J Am Acad Dermatol 1993; 29: 519-535.
56. Marangoni A, Sambri V, Cavrini F, Frabetti A, Storni E, Accardo S, Servidio D, Foschi F, Montebugnoli L, Prati C, Cevenini R. Treponema denticola infection is not a cause of false positive Treponema pallidum serology. New Microbiol 2005; 28: 215-221.
57. Erbelding EJ, Vlahov D, Nelson KE, Rompalo AM, Cohn S, Sanchez P, Quinn TC, Brathwaite W, Thomas DL. Syphilis serology in human immunodeficiency virus infection: evidence for false-negative fluorescent treponemal testing. J Infect Dis 1997; 176: 1397-1400.
58. Schmidt BL. Evaluation of a new particle gel immunoassay for determination of antibodies against Treponema pallidum. J Clin Microbiol 2004; 42: 2833-2835.
59. Schmidt BL, Edjlalipour M, Luger A. Comparative evaluation of nine different enzyme-linked immunosorbent assays for determination of antibodies against Treponema pallidum in patients with primary syphilis. J Clin Microbiol 2000; 38: 1279-1282.
60. Hicks CB, Benson PM, Lupton GP, Tramont EC. Seronegative secondary syphilis in a patient infected with the human immunodeficiency virus (HIV) with Kaposi sarcoma. A diagnostic dilemma. Ann Intern Med 1987; 107: 492-495.
61. Augenbraun M, Rolfs R, Johnson R, Joesoef R, Pope V. Treponemal specific tests for the serodiagnosis of syphilis. Syphilis and HIV Study Group. Sex Transm Dis 1998; 25: 549-552.
62. Haslett P, Laverty M. The prozone phenomenon in syphilis associated with HIV infection. Arch Intern Med 1994; 154: 1643-1644.
63. Malone JL, Wallace MR, Hendrick BB, LaRocco A, Jr., Tonon E, Brodine SK, Bowler WA, Lavin BS, Hawkins RE, Oldfield EC, III. Syphilis and neurosyphilis in a human immunodeficiency virus type-1 seropositive population: evidence for frequent serologic relapse after therapy. Am J Med 1995; 99: 55-63.
64. Janier M, Chastang C, Spindler E, Strazzi S, Rabian C, Marcelli A, Morel P. A prospective study of the influence of HIV status on the seroreversion of serological tests for syphilis. Dermatology 1999; 198: 362-369.
65. Rompalo AM, Cannon RO, Quinn TC, Hook EW. III. Association of biologic false-positive reactions for syphilis with human immunodeficiency virus infection. J Infect Dis 1992; 165: 1124-1126.