Production of pellets by pharmaceutical extrusion and spheronisation. Part II. Physical characterisation of pellets;Obtenção de pellets por extrusão e esferonizaç ão farmacêutica. Parte II. Avaliação das características física de pellets

Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences

Volumn 42, Issue 3, 2006, Pages 309-318

  Santos, Helton Max Massaranduba ^a   Veiga, Francisco José Batista ^a   De Pina, Eugênica Maria Soares Tavares ^a   De Sousa, João José Martins Simões ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Pelletisation; Pellets; Physical characterisation; Sphere

Indexed keywords

CAPSULE FILLING; DRUG GRANULE; DRUG PELLET; DRUG STORAGE; FILM COATING; PELLET EXTRUSION; REVIEW; SPHERONIZATION;

EID: 33845514880     PISSN: 15169332     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (54)

1. BEDDOW, J.K. Morphological analysis, ten years of progress. Particle Sci. Technol., v.1, p.101-123, 1983.
2. CARLI, F.; COLOMBO, I.; SIMIONI, L.; BIANCHINE, L.; BIANCHINE, R. The effect of compression on the capillary microstructure of tablets. J. Pharm. Pharmacol., v.33, p.129-135, 1981.
3. CARLI, F.; MOTTA, A. Particle size and surface area distributions of pharmaceutical powders by microcomputerized mercuryporosimetry. J. Pharm. Sci., v.73, p.197-203, 1984.
4. CHAPMAN, S.R.; ROWE, R.C.; NEWTON, J.M. Characterisation of the sphericity of particles by the one plane critical stability. J. Pharm. Pharmacol., v.40, p.503-505, 1988.
5. CHOPRA, R.; NEWTON, J.M.; ALDERBORN, G.; PODCZECK, F. Preparation of pellets of different shape and their characterization. Pharm. Dev. Technol., v.6, p.495-503, 2001.
6. CLARK, G.M.; NEWTON, J.M.; SHORT, M.D. Gastrointestinal transit of pellets of differing size and density. Int. J. Pharm., v.100, p.81.92, 1993.
7. COX, B.P. A method of assigning numerical and percentage values to the degree of roundness. J. Paleontol., v.1, p.179-183, 1927.
8. DEVEREUX, J.E.; NEWTON, J.M.; SHORT, M.B. The influence of density on the gastrointestinal transit of pellets. J. Pharm. Pharmacol., v.42, p.500-501, 1990.
9. FIELDEN, K.E.; NEWTON, J.M.; ROWE, R.C. The influence of moisture content on spheronisation of extrudate processed by a ram extruder. Int. J. Pharm., v.97, p.79-92, 1993.
10. FUJIWARA, H.; TODA, J.; KATO, M. Studies on pore structure of granules by mercury porosimetry. Chem. Pharm. Bulletin, v.14, p.601-607, 1966.
11. HAUSNER, H.H. Characterisation of the powder particle shape. Planseeber. Pulvermet., v.14, p.75-84, 1966.
12. HELLÉN, L.; YLIRUUSI, J.; KRISTOFFERSSON, E. Process variable of instant granulator and spheroniser: II. Size and size distributions of pellets. Int J. Pharm., v.96, p.205-216, 1993a.
13. HELLÉN, L.; YLIRUUSI, J.; MUTTONEN, E.; KRISTOFFERSSON, E. Process variable of the radial screen extruder: II. Size and size distributions of pellets. Pharm. Tech. Int., v.5, p.44-53, 1993b.
14. HUTCHINGS, I.M. Deformation and fracture of brittle particles. In: ADAMS, M.J.; BISWAS, S.K.; BRISCOE, B.J. (Eds.), Solid-Solid Interactions. London: Imperial College Press, 1996. p. 211-224.
15. JOHANSSON, B.; ALDERBORN, G. The effect of shape and porosity on the compression behaviour and tablet forming ability of granular materials formed from microcrystalline cellulose. Eur. J. Pharm. Biopharm., v.52, p.347-357, 2001.
16. JOHANSSON, B.; NICKLASSON, F.; ALDERBORN, G. Effect of pellet size on degree of deformation and densification during compression and on compactability of microcrystalline cellulose pellets. Int. J. Pharm., v.163, p.35-48, 1998.
17. JOHANSSON, B.; WIKBERG, M.; EK, R., ALDERBORN, G. Compression behaviour and compactability of microcrystalline cellulose pellets in relation to their pore structure and mechanical properties. Int. J. Pharm., v.117, p.57-73, 1995.
18. JUPPO, A.M. Porosity parameters of lactose, glucose and mannitol granules obtained by mercury porosimetry. Int. J. Pharm., v.129, p.1-12, 1996a.
19. JUPPO, A.M. Change in porosity parameters of lactose, glucose and mannitol granules caused by low compression force. Int. J. Pharm., v.130, p.149-157, 1996b.
20. JUPPO, A.M.; YLIRUUSI, J. Effect of amount of granulation liquid on total pore volume and pore size distrinution of lactose, glucose and mannitol granules. Eur. J. Pharm. Biopharm., v.40, p.299-309, 1994.
21. LINDNER, H.; KLEINEBUDDE, P. Anwendung der automatischen bildanalyse zur charakterisierung von pellets. Pharm. Ind., v.55, p.694-701, 1993.
22. LINDNER, H.; KLEINEBUDDE, P. Use of powdered cellulose for production of pellets by extrusion/spheronisation. J. Pharm. Pharmacol., v.46, p.2-7, 1994.
23. MARTIN, A.N. Physical Pharmacy. 4th ed., Philadelphia: Lea & Febiger, 1993. 622pp.
24. MATTSSON, S.; NYSTRÖM, C. The use of mercury porosimetry in assessing the effect of different binders on the pore structure and bonding properties of pellets. Eur. J. Pharm. Biopharm., v.52, p.237-247, 2001.
25. MEHTA, A.M. Evaluation and characterization of pellets. In: GHEBRE-SELLASSIE, I. Ed., Pharmaceutical pelletization technology., New York: Marcel Dekker Inc., 1989. p.241-266.
26. NEWTON, J.M.; PETERSSON, J.; PODCZECK, F.; CLARKE, A.; BOOTH, S. The influence of formulation variables on the properties of pellets containing a self-emulsifying mixture. J. Pharm. Sci., v.90, p.987-995, 2001.
27. NICKLASSON, F.; JOHANSSON, B.; ALDERBORN, G. Occurrence of fragmentation during compression of pellets prepared from a 4 to 1 mixture of dicalcium phosphate dehydrate and microcrystalline cellulose. Eur. J. Pharm. Sci., v.7, p.221-229, 1999a.
28. NICKLASSON, F.; JOHANSSON, B.; ALDERBORN, G. Tabetting behaviour of pellets of a series of porosities - a comparison between pellets of two different compositions. Eur. J. Pharm. Sci., v.8, p.11-17, 1999b.
29. NYSTRÖM, C.; MALMQVIST, K. Comparison between the ring gap sizer and dry sieving. Acta Pharm. Suec., v.14, p.309-316, 1977.
30. NYSTRÖM, C.; STANLEY-WOOD, N. Measurement of particle size of free-flowing material with a ring gap sizer. Acta Pharm. Suec., v.13, p.277-284, 1976.
31. NYSTRÖM, C.; STANLEY-WOOD, N. Measurement of the minimum dimension of particles by a ring gap sizer. Acta Pharm. Suec., v.14, p.181-190, 1977.
32. PALMER, H.K.; ROWE, R.C. The application of mercury porosimetry to porous polymer powder. Powder Technol., v.9, p.1981-1986, 1974.
33. PENTLAND, A. A method of measuring the angularity of sands. Proceedings and transcription of the Royal Society of Canada, v. 21, p. 1927.
34. PODCZECK, F. Measurement of surface roughness of tablets made from polyethylene glycol powders of various molecular weights. Pharm. Pharmacol. Commun., v.4, p.179-182, 1998.
35. PODCZECK, F.; NEWTON, J.M. A shape fator to characterise the quality of spheroids. J. Pharm. Pharmacol., v.46, p.82-85, 1994.
36. PODCZECK, F.; NEWTON, J.M. The evaluation of a three-dimensional shape fator for the quantitative assessment of the sphericity and surface roughness of pellets. Int. J. Pharm., v.124, p.253-259, 1995.
37. PODCZECK, F.; RAHMAN, S.R.; NEWTON, J.M. Evaluation of a standardised procedure to assess the shape of pellets using image analysis. Int. J. Pharm., v.192, p.123-138, 1999.
38. RIIPPI, M.; ANTIKAINEN, O.; NISKANEN, T.; YLIRUUSI, J. The effect of compression force on surface structure, crushing strength, friability, and disintegration time of erythromycin acistrate tablets. Eur. J. Pharm. Biopharm., v.46, p.339-345, 1998.
39. SALAKO, M.; PODCZECK, F.; NEWTON, J.M. Investigation into the deformability and tensile strength of pellets. Int. J. Pharm., v.168, p.49-57, 1998.
40. SANTOS, H.; VEIGA, F.; PINA, M.; PODCZECK, F.; SOUSA, J. Physical properties of chitosan pellets produced by extrusion-spheronisation: influence of formulation variables. Int. J. Pharm., v.246, p.153-169, 2002.
41. SANTOS, H.; VEIGA, F.; PINA, M.; SOUSA, J. Compaction, compression and drug release characteristics of xanthan gum pellets of different compositions. Eur. J. Pharm. Sci., v.21, p.271-281, 2004.
42. SANTOS, H.; VEIGA, F.; PINA, M.; SOUSA, J. Obtenção de pellets por extrusão e esferonização farmacêutica. Parte I. Avaliação das variáveis tecnológicas e de formulação. Rev. Bras. Cienc. Farm., v.40, p.455-470, 2004.
43. SANTOS, H.; VEIGA, K.; PINA, M.; SOUSA, J. Compaction, compression and drug release properties of diclotenae sodium and ibuprofen pellets comprising xanthan gum a a sustained release agent. Int. J. Pharm., v.295, p.15-27, 2005.
44. SCHNEIDERHÖHN, P. Eine vergleichende studie über methoden zur quantitativen bestimmung von abrundung und form an sandkörnern. Heidelb. Beitr. Miner. Petrogr., v.4, p.172-191, 1954.
45. SCHRÖDER, M.; KLEINEBUDDE, P. Structure of disintegrating pellets with regard to fractal geometry. Pharm. Res., v.12, p.1694-1700, 1995.
46. SHIPWAY, P.H.; HUTCHINGS, I.M. Fracture of brittle spheres under compression and impact loading: I-Elastic stress distribution. Phil. Mag., v.A67, p.1389-1404, 1993.
47. TSUBAKI, J.; JIMBO, G. A proposed new characterization of particle shape and its application. Powder Technol., v.22, p.161-169, 1979,
48. VERTOMMEN, J.; ROMBAUT, R.; KINGET, R. Internal and external structure of pellets made in rotary processor. Int. J. Pharm., v.161, p.225-236, 1998.
49. th, Manchester, 1992. Proceedings. v.3, p. 51-62.
50. WAN, L.S.C.; HENG, P.W.S.; LIEW, C.V. Spheronization conditions on spheroids shape and size. Int. J. Pharm., v.96, p.59-65, 1993.
51. WAN, D.S.; JEYABALAN, T. A simple apparatus for measuring the crushing strength of pellets. Acta. Pharm. Technol., v.32, p.197-199, 1986.
52. WIKBERG, M.; ALDERBORN, G. Compression characteristics of granulated materials. II. Evaluation of granule fragmentation during compression by tablet permeability and porosity measurements. Int. J. Pharm., v.62, p.229-241, 1990.
53. WIKBERG, M., ALDERBORN, G. Compression characteristics of granulated materials. VI. Pore size distributions, assessed by mercury penetration, of compacts of two lactose granulations with different fragmentation propensities. Int. J. Pharm., v.84, p.191-195, 1992.
54. ZUURMAN, K.; RIEPMA, K.A.; BOLHUIS, G.K.; VROMANS, H.; LERK, C.F. The relationship between bulk density and compatibility of lactose granulations. Int. J. Pharm., v.102, p.1-9, 1994.