메뉴 건너뛰기




Volumn 119, Issue 3, 2007, Pages 361-367

The respective and combined anticoagulant effects of recombinant human activated protein C, melagatran and heparins using CAT

Author keywords

Calibrated automated thrombography; Melagatran; rhAPC; Thrombin generation

Indexed keywords

ANTICOAGULANTS; AZETIDINES; BENZYLAMINES; BLOOD COAGULATION; BLOOD COAGULATION TESTS; DRUG COMBINATIONS; DRUG SYNERGISM; FEMALE; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; MALE; PROTEIN C; RECOMBINANT PROTEINS; SEPSIS; THROMBIN TIME;

EID: 33845511129     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2006.03.004     Document Type: Article
Times cited : (13)

References (29)
  • 1
    • 0035826096 scopus 로고    scopus 로고
    • Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis
    • Bernard G.R., Vincent J.L., Laterre P.F., LaRosa S.P., Dhainaut J.F., Lopez-Rodriguez A., et al. Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344 (2001) 699-709
    • (2001) N Engl J Med , vol.344 , pp. 699-709
    • Bernard, G.R.1    Vincent, J.L.2    Laterre, P.F.3    LaRosa, S.P.4    Dhainaut, J.F.5    Lopez-Rodriguez, A.6
  • 3
    • 0034971291 scopus 로고    scopus 로고
    • A cell-based model of hemostasis
    • Hoffman M., and Monroe III D.M. A cell-based model of hemostasis. Thromb Haemost 85 (2001) 958-965
    • (2001) Thromb Haemost , vol.85 , pp. 958-965
    • Hoffman, M.1    Monroe III, D.M.2
  • 4
    • 0037352375 scopus 로고    scopus 로고
    • Recombinant human activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial
    • Vincent J.L., Angus D.C., Artigas A., Kalil A., Basson B.R., Jamal H.H., et al. Recombinant human activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med 31 (2003) 834-840
    • (2003) Crit Care Med , vol.31 , pp. 834-840
    • Vincent, J.L.1    Angus, D.C.2    Artigas, A.3    Kalil, A.4    Basson, B.R.5    Jamal, H.H.6
  • 5
    • 0344752866 scopus 로고    scopus 로고
    • Clinical review: drotrecogin alfa (activated) as adjunctive therapy for severe sepsis-practical aspects at the bedside and patient identification
    • Laterre P.F., and Wittebole X. Clinical review: drotrecogin alfa (activated) as adjunctive therapy for severe sepsis-practical aspects at the bedside and patient identification. Crit Care 7 (2003) 445-450
    • (2003) Crit Care , vol.7 , pp. 445-450
    • Laterre, P.F.1    Wittebole, X.2
  • 6
    • 0037803423 scopus 로고    scopus 로고
    • Recombinant human activated Protein C Worldwide Evaluation in Sepsis (PROWESS) study group. Drotrecogin alfa (activated) in the treatment of severe sepsis patients with multiple-organ dysfunction: data from the PROWESS trial
    • Dhainaut J.F., Laterre P.F., Janes J.M., Bernard G.R., Artigas A., Bakker J., et al. Recombinant human activated Protein C Worldwide Evaluation in Sepsis (PROWESS) study group. Drotrecogin alfa (activated) in the treatment of severe sepsis patients with multiple-organ dysfunction: data from the PROWESS trial. Intense Care Med 29 (2003) 894-903
    • (2003) Intense Care Med , vol.29 , pp. 894-903
    • Dhainaut, J.F.1    Laterre, P.F.2    Janes, J.M.3    Bernard, G.R.4    Artigas, A.5    Bakker, J.6
  • 7
    • 0142218380 scopus 로고    scopus 로고
    • Pharmacokinetics and anticoagulant effect of the direct thrombin inhibitor melagatran following subcutaneous administration to healthy young men
    • Johansson S., Wahlander K., Larson G., Ohlsson L., Larsson M., and Eriksson U.G. Pharmacokinetics and anticoagulant effect of the direct thrombin inhibitor melagatran following subcutaneous administration to healthy young men. Blood Coagul Fibrinolysis 14 (2003) 677-684
    • (2003) Blood Coagul Fibrinolysis , vol.14 , pp. 677-684
    • Johansson, S.1    Wahlander, K.2    Larson, G.3    Ohlsson, L.4    Larsson, M.5    Eriksson, U.G.6
  • 8
    • 22444445631 scopus 로고    scopus 로고
    • Ximelagatran: an orally active direct thrombin inhibitor
    • Gulseth M.P. Ximelagatran: an orally active direct thrombin inhibitor. Am J Health-Syst Pharm 62 (2005) 1451-1467
    • (2005) Am J Health-Syst Pharm , vol.62 , pp. 1451-1467
    • Gulseth, M.P.1
  • 9
    • 0037048939 scopus 로고    scopus 로고
    • Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement: the METHRO II randomised trial
    • Eriksson B.I., Bergqvist D., Kalebo P., Dahl O.E., Lindbratt S., Bylock A., et al. Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement: the METHRO II randomised trial. Lancet 360 (2002) 1441-1447
    • (2002) Lancet , vol.360 , pp. 1441-1447
    • Eriksson, B.I.1    Bergqvist, D.2    Kalebo, P.3    Dahl, O.E.4    Lindbratt, S.5    Bylock, A.6
  • 10
    • 4644285241 scopus 로고    scopus 로고
    • Clinical experience with ximelagatran in orthopaedic surgery
    • Eriksson B. Clinical experience with ximelagatran in orthopaedic surgery. Drugs 64 (2004) S27-S35
    • (2004) Drugs , vol.64
    • Eriksson, B.1
  • 11
    • 10044284360 scopus 로고    scopus 로고
    • Drotrecogin alfa activated (recombinant human activated protein C) in combination with heparin or melagatran: effects on prothrombin time and activated partial thromboplastin time
    • Koestenberger M., Cvirn G., Gallistl S., and Muntean W. Drotrecogin alfa activated (recombinant human activated protein C) in combination with heparin or melagatran: effects on prothrombin time and activated partial thromboplastin time. Blood Coagul Fibrinolysis 15 (2004) 693-697
    • (2004) Blood Coagul Fibrinolysis , vol.15 , pp. 693-697
    • Koestenberger, M.1    Cvirn, G.2    Gallistl, S.3    Muntean, W.4
  • 12
    • 22144441728 scopus 로고    scopus 로고
    • Additive effects of anticoagulants: recombinant human activated protein C and heparin or melagatran, in tissue factor-activated umbilical-cord plasma
    • Koestenberger M., Gallistl S., Muntean W., Leschnik B., Fritsch P., and Cvirn G. Additive effects of anticoagulants: recombinant human activated protein C and heparin or melagatran, in tissue factor-activated umbilical-cord plasma. Thromb Haemost 94 (2005) 69-74
    • (2005) Thromb Haemost , vol.94 , pp. 69-74
    • Koestenberger, M.1    Gallistl, S.2    Muntean, W.3    Leschnik, B.4    Fritsch, P.5    Cvirn, G.6
  • 13
    • 9644255788 scopus 로고    scopus 로고
    • Anticoagulant action of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, in umbilical cord and adult plasma: an in vitro examination
    • Koestenberger M., Gallistl S., Cvirn G., Baier K., Leschnik B., and Muntean W. Anticoagulant action of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, in umbilical cord and adult plasma: an in vitro examination. Thromb Res 115 (2005) 135-142
    • (2005) Thromb Res , vol.115 , pp. 135-142
    • Koestenberger, M.1    Gallistl, S.2    Cvirn, G.3    Baier, K.4    Leschnik, B.5    Muntean, W.6
  • 14
    • 8444233553 scopus 로고    scopus 로고
    • Other supportive therapies in sepsis: an evidence-based review
    • Trzeciak S., and Dellinger R.P. Other supportive therapies in sepsis: an evidence-based review. Crit Care Med 32 Suppl 11 (2004) S 571-S 577
    • (2004) Crit Care Med , vol.32 , Issue.SUPPL. 11
    • Trzeciak, S.1    Dellinger, R.P.2
  • 15
    • 4644308426 scopus 로고    scopus 로고
    • Heparin and low-molecular-weight heparin: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
    • Hirsh J., and Raschke R. Heparin and low-molecular-weight heparin: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126 (2004) S188-S203
    • (2004) Chest , vol.126
    • Hirsh, J.1    Raschke, R.2
  • 17
    • 0033214353 scopus 로고    scopus 로고
    • "Normal" thrombin generation
    • Butenas S., van't Veer C., and Mann K.G. "Normal" thrombin generation. Blood 94 (1999) 2169-2178
    • (1999) Blood , vol.94 , pp. 2169-2178
    • Butenas, S.1    van't Veer, C.2    Mann, K.G.3
  • 19
    • 2442481465 scopus 로고    scopus 로고
    • The anticoagulant action of recombinant human activated protein C (rhAPC, drotrecogin alpha activated): comparison between cord and adult plasma
    • Cvirn G., Gallistl S., Koestenberger M., Baier K., Fritsch P., Greilberger J., et al. The anticoagulant action of recombinant human activated protein C (rhAPC, drotrecogin alpha activated): comparison between cord and adult plasma. Thromb Haemost 91 (2004) 912-918
    • (2004) Thromb Haemost , vol.91 , pp. 912-918
    • Cvirn, G.1    Gallistl, S.2    Koestenberger, M.3    Baier, K.4    Fritsch, P.5    Greilberger, J.6
  • 20
    • 1242284639 scopus 로고    scopus 로고
    • Coagulopathy of sepsis
    • Dempfle C.E. Coagulopathy of sepsis. Thromb Haemost 91 (2004) 213-224
    • (2004) Thromb Haemost , vol.91 , pp. 213-224
    • Dempfle, C.E.1
  • 21
    • 0037104691 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics and clinical effects of the oral direct thrombin inhibitor ximelagatran in acute treatment of patients with pulmonary embolism and deep vein thrombosis
    • Wahlander K., Lapidus L., Olsson C.G., Thuresson A., Eriksson U.G., Larson G., et al. Pharmacokinetics, pharmacodynamics and clinical effects of the oral direct thrombin inhibitor ximelagatran in acute treatment of patients with pulmonary embolism and deep vein thrombosis. Thromb Res 107 (2002) 93-99
    • (2002) Thromb Res , vol.107 , pp. 93-99
    • Wahlander, K.1    Lapidus, L.2    Olsson, C.G.3    Thuresson, A.4    Eriksson, U.G.5    Larson, G.6
  • 22
    • 0035251672 scopus 로고    scopus 로고
    • The direct thrombin inhibitor melagatran and its oral prodrug H 376/95: intestinal absorption properties, biochemical and pharmacodynamic effects
    • Gustafsson D., Nystrom J., Carlsson S., Bredberg U., Eriksson U., Gyzander E., et al. The direct thrombin inhibitor melagatran and its oral prodrug H 376/95: intestinal absorption properties, biochemical and pharmacodynamic effects. Thromb Res 101 (2001) 171-181
    • (2001) Thromb Res , vol.101 , pp. 171-181
    • Gustafsson, D.1    Nystrom, J.2    Carlsson, S.3    Bredberg, U.4    Eriksson, U.5    Gyzander, E.6
  • 23
    • 3242673971 scopus 로고    scopus 로고
    • Thrombin generation assays: accruing clinical relevance
    • Hemker H.C., Al Dieri R., and Beguin S. Thrombin generation assays: accruing clinical relevance. Curr Opin Hematol 11 (2004) 170-175
    • (2004) Curr Opin Hematol , vol.11 , pp. 170-175
    • Hemker, H.C.1    Al Dieri, R.2    Beguin, S.3
  • 25
    • 13244253700 scopus 로고    scopus 로고
    • Thrombin generation for the control of heparin treatment, comparison with the activated partial thromboplastin time
    • Al Dieri R., Alban S., Beguin S., and Hemker H.C. Thrombin generation for the control of heparin treatment, comparison with the activated partial thromboplastin time. J Thromb Haemost 2 (2004) 1395-1401
    • (2004) J Thromb Haemost , vol.2 , pp. 1395-1401
    • Al Dieri, R.1    Alban, S.2    Beguin, S.3    Hemker, H.C.4
  • 26
    • 1842737656 scopus 로고    scopus 로고
    • The inhibitory effect of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, compared with enoxaparin and r-hirudin on ex vivo thrombin generation in human plasma
    • Bostrom S.L., Hansson G.F., Sarich T.C., and Wolzt M. The inhibitory effect of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, compared with enoxaparin and r-hirudin on ex vivo thrombin generation in human plasma. Thromb Res 113 (2004) 85-91
    • (2004) Thromb Res , vol.113 , pp. 85-91
    • Bostrom, S.L.1    Hansson, G.F.2    Sarich, T.C.3    Wolzt, M.4
  • 27
    • 7044239113 scopus 로고    scopus 로고
    • Phenotyping the haemostatic system by thrombography-potential for the estimation of thrombotic risk
    • Regnault V., Hemker H.C., Wahl D., and Lecompte T. Phenotyping the haemostatic system by thrombography-potential for the estimation of thrombotic risk. Thromb Res 114 (2004) 539-545
    • (2004) Thromb Res , vol.114 , pp. 539-545
    • Regnault, V.1    Hemker, H.C.2    Wahl, D.3    Lecompte, T.4
  • 28
    • 0029085314 scopus 로고
    • Thrombin generation in plasma: its assessment via the endogenous thrombin potential
    • Hemker H.C., and Beguin S. Thrombin generation in plasma: its assessment via the endogenous thrombin potential. Thromb Haemost 74 (1995) 134-138
    • (1995) Thromb Haemost , vol.74 , pp. 134-138
    • Hemker, H.C.1    Beguin, S.2
  • 29
    • 0345195222 scopus 로고    scopus 로고
    • Inhibitory mechanism of the protein C pathway on tissue factor-induced thrombin generation. Synergistic effect in combination with tissue factor pathway inhibitor
    • Van't Veer C., Golden N.J., Kalafatis M., and Mann K.G. Inhibitory mechanism of the protein C pathway on tissue factor-induced thrombin generation. Synergistic effect in combination with tissue factor pathway inhibitor. J Biol Chem 272 (1997) 7983-7994
    • (1997) J Biol Chem , vol.272 , pp. 7983-7994
    • Van't Veer, C.1    Golden, N.J.2    Kalafatis, M.3    Mann, K.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.