Polymorphism of the 3′-untranslated region of the leptin receptor gene, but not the adiponectin SNP45 polymorphism, predicts type 2 diabetes: A population-based study

Diabetes Care

Volumn 29, Issue 11, 2006, Pages 2509-2511

  Nannipieri, Monica ^a   Posadas, Rosalinda ^a   Bonotti, Alessandra ^a   Williams, K E N ^b   Gonzalez Villalpando, Clicerio ^c   Stern, Michael P ^b   Ferrannini, Ele ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c AMERICAN BRITISH COWDRAY MEDICAL CENTER   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; DNA FRAGMENT; LEPTIN RECEPTOR; CELL SURFACE RECEPTOR;

3' UNTRANSLATED REGION; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA POLYMORPHISM; HUMAN; IMPAIRED GLUCOSE TOLERANCE; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PREVALENCE; SCREENING; SINGLE NUCLEOTIDE POLYMORPHISM; DISEASE COURSE; FOLLOW UP; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; GLUCOSE INTOLERANCE; MEXICO; PREDICTION AND FORECASTING; RISK FACTOR; STATISTICAL MODEL;

3' UNTRANSLATED REGIONS; ADIPONECTIN; DIABETES MELLITUS, TYPE 2; DISEASE PROGRESSION; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLUCOSE INTOLERANCE; HUMANS; LOGISTIC MODELS; MEXICO; POLYMORPHISM, SINGLE NUCLEOTIDE; PREDICTIVE VALUE OF TESTS; RECEPTORS, CELL SURFACE; RISK FACTORS;

EID: 33845508086     PISSN: 01495992     EISSN: 01495992     Source Type: Journal    
DOI: 10.2337/dc06-0355     Document Type: Article

References (19)

1. Albu JB, Curi M, Shur M, Murphy L, Matthews DE, Pi-Sunyer FX: Systemic resistance to the antilipolytic effect of insulin in black and white women with visceral obesity. Am J Physiol 277:E551-E560, 1999
2. Francke S, Clement K, Dina C, Inoue H, Behn P, Vatin V, Basdevant A, Guy-Grand B, Permutt MA, Froguel P, Hager J: Genetic studies of the leptin receptor gene in morbidly obese French Caucasian families. Hum Genet 100:491-496, 1997
3. Oksanen L, Kaprio J, Mustajoki P, Kontula K: A common pentanucleotide polymorphism of the 3′-untranslated part of the leptin receptor gene generates a putative stem-loop motif in the mRNA and is associated with serum insulin levels in obese individuals. Int J Obes Relat Metab Disord 22:634-640, 1998
4. Lakka HM, Oksanen L, Tuomainen TP, Kontula K, Salonen JT: The common pentanucleotide polymorphism of the 3′-untranslated region of the leptin receptor gene is associated with serum insulin levels and the risk of type 2 diabetes in nondiabetic men: a prospective case-control study. J Intern Med 248:77-83, 2000
5. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y: Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257:79-83, 1999
6. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K, Nishida M, Kihara S, Sakai N, Nakajima T, Hasegawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Hanafusa T, Matsuzawa Y: Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 20:1595-1599, 2000
7. Vionnet N, Hani El-H, Dupont S, Gallina S, Francke S, Dotte S, De Matos F, Durand E, Lepretre F, Lecoeur C, Gallina P, Zekiri L, Dina C, Froguel P: Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. Am J Hum Genet 67:1470-1480, 2000
8. Kissebah AH, Sonnenberg GE, Myklebust J, Goldstein M, Broman K, James RG, Marks JA, Krakower GR, Jacob HJ, Weber J, Martin L, Blangero J, Comuzzie AG: Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc Natl Acad Sci U S A 97:14478-14483, 2000
9. Hara K, Boutin P, Mori Y, Tobe K, Dina C, Yasuda K, Yamauchi T, Otabe S, Okada T, Eto K, Kadowaki H, Hagura R, Akanuma Y, Yazaki Y, Nagai R, Taniyama M, Matsubara K, Yoda M, Nakano Y, Tomita M, Kimura S, Ito C, Froguel P, Kadowaki T: Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 51:536-540, 2002
10. Menzaghi C, Ercolino T, Di Paola R, Berg AH, Warram JH, Scherer PE, Trischitta V, Doria A: A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes 51:2306-2312, 2002
11. Stumvoll M, Tschritter O, Fritsche A, Staiger H, Renn W, Weisser M, Machicao F, Häring H: Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. Diabetes 51:37-41, 2002
12. Nannipieri M, Posadas R, Williams K, Politi E, Gonzales-Villalpando C, Stern MP, Ferrannini E: Association between polymorphisms of the atrial natriuretic peptide gene and proteinuria: a population-based study. Diabetologia 46:429-432, 2003
13. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 25 (Suppl. 1):S5-S20, 2002
14. Miller SA, Dykes DD, Polesky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215, 1988
15. + channels in pancreatic β-cells. Diabetes 46:1087-1093, 1997
16. Emilsson V, Liu YL, Cawthorne MA, Morton NM, Davenport M: Expression of the leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes 46:313-316, 1997
17. Brown CY, Lagnado CA, Goodall GJ: A cytokine mRNA-destabilizing element that is structurally and functionally distinct from A+U-rich elements. Proc Natl Acad Sci U S A 93:17721-17725, 1996
18. Vasseur F, Helbecque N, Dina C, Lobbens S, Delannoy V, Gaget S, Boutin P, Vaxillaire M, Lepretre F, Dupont S, Hara K, Clement K, Bihain B, Kadowaki T, Froguel P: Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet 11:2607-2614, 2002
19. Gu HF, Abulaiti A, Östenson CG, Humphreys K, Wahlestedt C, Brookes AJ, Efendic S: Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish Caucasians. Diabetes 53 (Suppl. 1):S31-S35, 2004