Effects of the Smad signaling pathway on differentiation of marrow-derived cardiac stem cells toward cardiomyocytes

Acta Anatomica Sinica

Volumn 37, Issue 5, 2006, Pages 525-529

  Wang, Xing Yan ^a   Tan, Yu Zhen ^a   Wang, Hai Jie ^a   Zhang, Gui Tao ^a   He, Qi Zhi ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

BMP 2; cTnT; GATA 4; Marrow derived cardiac stem cells; Smad signaling pathway; Western blotting rats

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BONE MORPHOGENETIC PROTEIN 2; CARRIER PROTEIN; MESSENGER RNA; SMAD PROTEIN; SMAD PROTEIN 1; SMAD PROTEIN 5; SMAD PROTEIN 8; TRANSCRIPTION FACTOR GATA 4;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL SHAPE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEART MUSCLE CELL; IMMUNOCYTOCHEMISTRY; MOLECULAR MECHANICS; MYOTUBE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; RAT STRAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STEM CELL; WESTERN BLOTTING;

EID: 33845506670     PISSN: 05291356     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Monzen K, Shiojima I, Hiroi Y, et al. Bone morphogenctic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase TAK1 and cardiac transcription factors Csx/Nkx2.5 and GATA-4[J]. Mol Cell Biol, 1999, 19 (10): 7096-7105.
2. Monzen K, Hiroi Y, Kudoh S, et al. Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation[J]. J Cell Biol, 2001, 153 (4): 687-698.
3. Ghosh-Choudhury N, Abboud SL, Nishimura R, et al. Requirement of RMP-2-induced phosphatidylinositol 3-kinase and Aktserine/Threonine kinase, in osteoblast differentiation and Smad-dependent BMP-2 gene transcription[J]. J Biol Chem, 2002, 277 (36): 33361-33368.
4. Sun LL, Tan YZH, Wang HJ, et al. Cloning culture of the marrow mesenchymal stem cells and their differentiation towards cardiomyocytes [J]. Fudan Univ J Med Sci, 2003, 30 (6): 519-523.
5. He QZH, Tna YZH, Wang HJ, et al. Effects of BMP-2 on differentiation of marrow-derived cardiac stem cells towards cardiomyocytes [J]. Acta Anatomica Sinica, 2005,36(5):498-502.
6. Lee CH, Jang YS, Her SJ, et al. Nordihydroguaiaetic acid, an antioxidant, inhibits transforming growth factor-β activity through the inhibition of Smad signaling pathway[J]. Exp Cell Res, 2003, 289 (2): 335-341.
7. Tan YZH, Wang HJ. Lineage commitment and differentiation of cardiac stem cells and their regulating mechanism[J]. Biomedical Engineering Foreign Medical Sciences, 2004, 27(1): 37-41.
8. Wang XY, Tan YZH. Mechanisms of signal transduction in bone morphogenetic protein-2-induced cardiomyocyte differentiation of cardiac stem cell[J]. J Med Mol Biol, 2005, 2 (2): 111-114.
9. Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-β family signaling[J]. Nature, 2003, 425 (9): 577-584.
10. Zwijsen A, Verschueren K, Huylebroeck D. New intracellular components of bone morphogenetic protein/Smad signaling cascades[J]. FEBS, 2003, 546 (1): 133-139.
11. Brown III CO, Chi X, Garcia-Gras E, et al. The cardiac determination factor, Nkx2.5, is activated by mutual confactors GATA-4 and Smad1/4 via a novel upsream enhancer [J]. J Biol Chem, 2004, 279 (11): 10659-10669.
12. Eriksson M, Leppa S. Mitogen-activated protein kinases and activator protein 1 are required for proliferation and cardiomyocyte differentiation of P19 embryonal carcinoma cells[J]. J Biol Chem, 2002, 277 (18): 15992-16001.
13. Ghosh-Choudhury N, Abboud SL, Nishimura R, et al. Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Aktserine/Threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription[J]. J Biol Chem, 2002, 277 (36): 33361-33368.
14. Schneider MD, Gaussin V, Lyons KM. Tempting fate: BMP signals for cardiac morphogenesis [J]. Cytokine Growth Factor Rew, 2003, 14 (1): 1-4.
15. Behafar A, Zingman LV, Hodgson DM, et al. Stem cell differentiation requires a paracrine pathway in the heart [J]. J FASEB, 2002, 48 (16):1558-1566.