Safety improvements of a Grignard reaction by controlling the reactant feed rate by on-line concentration monitoring using NIR

Organic Process Research and Development

Volumn 10, Issue 6, 2006, Pages 1282-1286

  Wiss, Jacques ^a   Ermini, Gianni ^b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Fachhochschule für Technik Wirtschaft und Soziale Arbeit ^*  (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33845495442     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op0601159     Document Type: Article

References (6)

1. Wiss, J.; Länzlinger, M.; Wermuth, M. Org. Process Res. Dev. 2005, 9, 365-371.
2. Kessler, R. W. Prozessanalytik; Wiley-VCH: Weinheim, 2006; p 117.
3. Thermal Process Safety; ESCIS (Expert Commission for Safety in the Swiss Chemical Industry): Basel, Switzerland, 1993; Booklet 8, pp 26-27.
4. GAMP-4, The Good Automated Manufacturing Practice (GAMP) Guide for Validation of Automated Systems in Pharmaceutical Manufacture. ISPE (International Society for Pharmaceutical Engineering), 2001.
5. Matlab and Simulink are registred trademarks of The MathWorks Inc., Natick, Massachusetts (U.S.A.)
6. PROFIBUS Technology and Applications, System Description. Profibus User Organization: Karlsruhe, Germany, October 2002.