Safety improvement of a grignard reaction using on-line NIR monitoring

Organic Process Research and Development

Volumn 9, Issue 3, 2005, Pages 365-371

  Wiss, Jacques ^a   Länzlinger, Markus ^b   Wermuth, Markus ^b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b SOLVIAS AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; GRIGNARD REACTION; LABORATORY TEST; NEAR INFRARED SPECTROSCOPY; SAFETY; SURFACE PROPERTY;

EID: 20444493237     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op049784h     Document Type: Article

References (10)

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4. Tamao, K.; Sumitani, K.; Kumada, M. J. Am. Chem. Soc. 1972, 94, 4374-4376.
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8. Jones, M. C. Plant and Operations Progress 1989, 8, No. 4, 200-205.
9. Martens, H.; Naes, T. Multivariate Calibration; Wiley: Chichester, 1996.
10. Guidance for Industry, PAT a Framework for Innovative Pharmaceutical Development, Manufacturing and Quality Assurance, U.S. Department of Health and Human Services, Food and Drug Administration, September 2004.