Combination of multiple genetic risk factors is synergistically associated with carotid atherosclerosis in Japanese subjects with type 2 diabetes

Diabetes Care

Volumn 29, Issue 11, 2006, Pages 2445-2451

  Yamasaki, Yoshimitsu ^a,h   Katakami, Naoto ^a   Sakamoto, Ken'ya ^a   Kaneto, Hideaki ^a   Matsuhisa, Munehide ^a   Sato, Hiroshi ^a   Hori, Masatsugu ^a   Haneda, Masakazu ^b   Kashiwagi, Atsunori ^c   Tanaka, Yasushi ^d   Kawamori, Ryuzo ^e   Kuno, Shin Ichi ^f,g  

^a OSAKA UNIVERSITY   (Japan)

^b ASAHIKAWA MEDICAL COLLEGE   (Japan)

^c SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^d ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e JUNTENDO UNIVERSITY   (Japan)

^f FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION   (Japan)

^g KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^h OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); LYMPHOTOXIN;

ADULT; AGED; ALLELE; ARTICLE; ATHEROSCLEROSIS; CAROTID ARTERY; CONTROLLED STUDY; DIABETIC PATIENT; ECHOGRAPHY; FEMALE; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; INTIMA; JAPAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; CAROTID ARTERY DISEASES; CAROTID ARTERY, COMMON; CAROTID ARTERY, INTERNAL; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; JAPAN; LYMPHOTOXIN-ALPHA; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; TUNICA INTIMA; TUNICA MEDIA;

EID: 33845489495     PISSN: 01495992     EISSN: 01495992     Source Type: Journal    
DOI: 10.2337/dc06-0871     Document Type: Article

References (25)

1. Chait A, Bierman EL: Pathogenesis of macrovascular disease in diabetes. In Joslin's Diabetes Mellitus. Kahn CR, Weir GC, Eds. Philadelphia, Lea & Febiger, 1994, p. 648-664
2. Nabel EG: Cardiovascular disease. N Engl J Med 349:60-72, 2003
3. Lusis AJ, Fogelman AM, Fonarow GC: Genetic basis of atherosclerosis. II. Clinical implications. Circulation 110:2066-2071, 2004
4. Ozaki K, Ohnishi Y, Iida A, Sekine A, Yamada R, Tsunoda T, Sato H, Sato H, Hori M, Nakamura Y, Tanaka T: Functional SNPs in the lymphotoxin-α gene that are associated with susceptibility to myocardial infarction. Nat Genet 32:650-654, 2002
5. Yamada Y, Izawa H, Ichihara S, Takatsu F, Ishihara H, Hirayama H, Sone T, Tanaka M, Yokota M: Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. N Engl J Med 347:1916-1923, 2002
6. 2c-adrenergic receptors and the risk of congestive heart failure. N Engl J Med 347:1135-1142, 2002
7. Nakata Y, Katsuya T, Rakugi H, Takami S, Sato N, Kamide K, Ohishi M, Miki T, HIgaki J, Ogihara T: Polymorphism of angiotensin converting enzyme, angiotensinogen, and apolipoprotein E genes in a Japanese population with cerebrovascular disease. Am J Hypertens 10:1391-1395, 1997
8. Chambless LE, Heiss G, Folsom AR, Rosamond W, Szklo M, Sharrett AR, Clegg LX: Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987-1993. Am J Epidemiol 146:483-494, 1997
9. Hodis HN, Mack WJ, LaBree L, Selzer RH, Liu CR, Liu CH, Azen SP: The role of carotid arterial intima-media thickness in predicting clinical coronary events. Ann Intern Med 128:262-269, 1998
10. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr, the Cardiovascular Health Study Collaborative Research Group: Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. N Engl J Med 340:14-22, 1999
11. Kawamori R, Yamasaki Y, Matsushima H, Nishizawa H, Nao K, Hougaku H, Maeda H, Handa N, Matsumoto M, Kamada T: Prevalence of carotid atherosclerosis in diabetic patients: ultrasound high-resolution B-mode imaging on carotid arteries. Diabetes Care 15:1290-1294, 1992
12. Yamasaki Y, Kawamori R, Matsushima H, Nishizawa H, Kodama M, Kajimoto Y, Morishima T, Kamada T: Atherosclerosis in carotid artery of young IDDM patients monitored by ultrasound high-resolution B-mode imaging. Diabetes 43:634-639, 1994
13. Pignoli P, Tremoli E, Poli A, Oreste P, Paoletti R: Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. Circulation 74:1399-1406, 1986
14. Simonson E, Keys A: The electrocardiographic exercise test: changes in scalar ECG and in mean spatial QRS and T vectors in two types of exercise: effect of absolute and relative body weight and comment on normal standards. Am Heart J 52:83-105, 1956
15. Schreyer SA, Vick GM, LeBoeuf RC: Loss of lymphotoxin-alpha but not tumor necrosis factor-alpha reduces atherosclerosis in mice. J Biol Chem 277:12364-12368, 2002
16. Robinson K, Mayer EL, Miller DP, Green R, van Lente F, Gupta A, Kottke-Marchant K, Savon SR, Selhub J, Nissen SE, Kutner M, Topol EJ, Jacobsen DW: Hyperhomocysteinemia and low pyridoxal phosphate: common and independent reversible risk factors for coronary artery disease. Circulation 92:2825-2830, 1995
17. Boushey CJ, Beresford SA, Omenn GS, Motulsky AG: A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA 274:1049-1057, 1995
18. Christensen B, Frosst P, Lussier-Cacan S, Selhub J, Goyette P, Rosenblatt DS, Genest J Jr, Rozen R: Correlation of a common mutation in the methylenetetrahydrofolate reductase gene with plasma homocysteine in patients with premature coronary artery disease. Arterioscler Thromb Vasc Biol 17:569-573, 1997
19. Arai K, Yamasaki Y, Kajimoto Y, Watada H, Umayahara Y, Kodama M, Sakamoto K, Hori M: Association of methylenetetrahydrofolate reductase gene polymorphism with carotid arterial wall thickening and myocardial infarction risk in NIDDM. Diabetes 46:2102-2104, 1997
20. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F: An insertion/deletion polymorphism in angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 86:1343-1346, 1990
21. Frost D, Pfohl M, Clemens P, Haring HU, Beischer W: Evaluation of the insertion/deletion ACE gene polymorphism as a risk factor for carotid artery intima-media thickening and hypertension in young type 1 diabetic patients. Diabetes Care 21:836-840, 1998
22. Mannami T, Katsuya T, Baba S, Inamoto N, Ishikawa K, Higaki J, Ogihara T, Ogata J: Low potentiality of angiotensin-converting enzyme gene insertion/deletion polymorphism as a useful predictive marker for carotid atherogenesis in a large general population of a Japanese city: the Suita Study. Stroke 32:1250-1256, 2001
23. Kogawa K, Nishizawa Y, Hosoi M, Kawagishi T, Maekawa K, Shoji T, Okuno Y, Horii H: Effect of polymorphism of apolipoprotein E and angiotensin-converting enzyme genes on arterial wall thickness. Diabetes 46:682-687, 1997
24. Rasmussen LM, Ledet T: Aortic atherosclerosis in diabetes mellitus is associated with an insertion/deletion polymorphism in the angiotensin I-converting enzyme gene: no relation between the polymorphism and aortic collagen content. Diabetologia 39:696-700, 1996
25. Yamasaki Y, Tsujino T, Kodama M, Kajimoto Y: DD genotype of the ACE gene as an atherosclerosis-independent risk factor for myocardial infarction. Circulation 96:3782, 1997