Evaluation of the insertion/deletion ACE gene polymorphism as a risk factor for carotid artery intima-media thickening and hypertension in young type 1 diabetic patients

Diabetes Care

Volumn 21, Issue 5, 1998, Pages 836-840

  Frost, Dietmar ^a,c   Pfohl, Martin ^b   Clemens, Pia ^b   Häring, Hans Ulrich ^b   Beischer, Wolfgang ^a  

^a Third Department of Medicine   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c Klinikum Stuttgart Burgerhospital   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE;

ADOLESCENT; ADULT; ARTERY INTIMA PROLIFERATION; ARTICLE; CAROTID ARTERY OBSTRUCTION; COMORBIDITY; DIABETIC ANGIOPATHY; DIABETIC NEPHROPATHY; DIABETIC RETINOPATHY; FEMALE; GENE DELETION; GENE INSERTION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; HYPERTENSION; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; RISK ASSESSMENT;

ADOLESCENT; ADULT; AGE FACTORS; ALBUMINURIA; ALLELES; CAROTID ARTERY DISEASES; CAROTID ARTERY, COMMON; CHOLESTEROL, LDL; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; DIABETIC RETINOPATHY; DNA TRANSPOSABLE ELEMENTS; FEMALE; GENE DELETION; GENE FREQUENCY; GENES; GENOTYPE; HEMOGLOBIN A, GLYCOSYLATED; HOMOZYGOTE; HUMANS; HYPERTENSION; LINEAR MODELS; LIPIDS; MALE; MICROCIRCULATION; PEPTIDYL-DIPEPTIDASE A; POLYMORPHISM, GENETIC; RISK FACTORS; SEX FACTORS; TUNICA INTIMA;

EID: 0031764656     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.21.5.836     Document Type: Article

References (36)

1. Cambien F, Poirier O, Lecerf L, Evans A, Cambou JP, Arveiler D, Luc G, Bard JM, Bara L, Ricard S, Tiret L, Amouyel P, Alhenc-Gelas F, Soubrier F: Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature 359:641-644, 1992
2. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F: An insertion/deletion polymorphism in angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 86:1343-1346, 1990
3. Hallab M, Bled F, Ebran JM, Suraniti S, Girault A, Fressinaud P, Marre M: Elevated serum angiotensin I converting enzyme activity in type I, insulin-dependent diabetic subjects with persistent microalbuminuria. Acta Diabetol 29:82-85, 1992
4. Tarnow L, Cambien F, Rossing P, Nielsen FS, Hansen BV, Lecerf L, Poirier O, Danilov S, Boelskifte S, Borch-Johnsen K, Parving HH: Insertion/deletion polymorphism in the angiotensin-I-converting enzyme gene is associated with coronary heart disease in IDDM patients with diabetic nephropathy. Diabetologia 38:798-803, 1995
5. Markus HS, Barley J, Lunt R, Bland JM, Jeffery S, Carter ND, Brown MM: Angiotensin-converting enzyme gene deletion polymorphism: a new risk factor for lacunar stroke but not carotid atheroma. Stroke 26:1329-1333, 1995
6. Zee RY, Lou YK, Griffiths LR, Morris BJ: Association of a polymorphism of the angiotensin I-converting enzyme gene with essential hypertension. Biochem Biophys Res Commun 184:9-15, 1992
7. Singer DRJ, Missouris CG, Jeffery S: Angiotensin-converting enzyme gene polymorphism: what to do about all the confusion? Circulation 94:236-239, 1996
8. Haber E: Angiotensin-converting enzyme and lipoprotein(a) as risk factors for myocardial infarction. Circulation 91:1888-1890, 1995
9. Grobbee DE, Bots ML: Carotid artery intima-media thickness as an indicator of generalized atherosclerosis. J Intern Med 236:567-573, 1994
10. Salonen JT, Salonen R: Ultrasound B-mode imaging in observational studies of atherosclerotic progression. Circulation 87 (Suppl. 2):II-56-II-65, 1993
11. Frost D, Beischer W: Carotiswandverän-derungen bei jungen Typ-1-Diabetikern. Dtsch Med Wochenschr 119:1225-1230, 1994
12. World Health Organization: WHO Expert Committee on Diabetes Mellitus. Geneva, World Health Org., 1980 (Tech. Rep. Ser., no. 640)
13. Doria A, Warram JH, Krolewski AS: Genetic predisposition to diabetic nephropathy: evidence for a role of the angiotensin I-converting enzyme gene. Diabetes 43:690-695, 1994
14. Koch M, Lehmann R, Pfohl M, Voelter W, Liebich H: Analysis of the deletion/insertion polymorphism of the angiotensin I-converting enzyme gene by capillary electrophoresis. Clin Chim Acta 248:197-203, 1996
15. Shanmugan V, Sell KW, Saha K: Mistyping AVE heterozygotes. PCR Methods Appl 3:120-121, 1993
16. Salonen R, Haapanen A, Salonen J: Measurement of intima-media thickness of common carotid arteries with high-resolution B-mode ultrasonography: inter- and intra-observer variability. Ultrasound Med Biol 17:225-230, 1991
17. Salonen R, Salonen JT: Determinants of carotid intima-media thickness: a population-based ultrasonography study in Eastern Finnish men. J Intern Med 229:225-231, 1991
18. Wendelhag I, Gustavsson T, Suurküla M, Wikstrand J: Ultrasound measurement of wall thickness in the carotid artery: fundamental principles and description of a computerized analysing system. Clin Physiol 11:565-577, 1991
19. Wikstrand J, Wendelhag I : Methodological considerations of ultrasound investigation of intima-media thickness and lumen diameter. J Intern Med 236:555-559, 1994
20. Ludwig E, Corneli PS, Anderson JL, Marshall HW, Laoulel JM, Ward RH: Angiotensin-converting enzyme gene polymorphism is associated with myocardial infarction but not with development of coronary stenosis. Circulation 91:2120-2124, 1995
21. Gardemann A, Weiss T, Schwartz O, Eberbach A, Katz N, Hehrlein FW, Tillmanns H, Waas W, Haberbosch W: Gene polymorphism but not catalytic activity of angiotensin I-converting enzyme is associated with coronary artery disease and myocardial infarction in low-risk patients. Circulation 92:2796-2799, 1995
22. Fujisawa T, Ikegami H, Shen GQ, Yamato E, Takekawa K, Nakagawa Y, Hamada Y, Ueda H, Rakugi H, Higaki J, Ohishi M, Fujii K, Fukuda M, Ogihara T: Angiotensin I-converting enzyme gene polymorphism is associated with myocardial infarction, but not with retinopathy or nephropathy, in NIDDM. Diabetes Care 18:983-985, 1995
23. Ruiz J, Blanché H, Cohen N, Velho G, Cambien F, Cohen D, Passa P, Froguel P: Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 91:3662-3665, 1994
24. Geroulakos G, O'Gorman DJ, Kalodiki E, Sheridan DJ, Nicolaides AN: The carotid intima-media thickness as a marker of the presence of severe symptomatic coronary artery disease. Eur Heart J 15:781-785, 1994
25. Rasmussen LM, Ledet T: Aortic atherosclerosis in diabetes mellitus is associated with an insertion/deletion polymorphism in the angiotensin I-converting enzyme gene: no relation between the polymorphism and aortic collagen content. Diabetologia 39:696-700, 1996
26. Bonithon-Kopp C, Ducimetiere P, Touboul PJ, Feve JM, Billaud E, Courbon D, Heraud V: Plasma angiotensin-converting enzyme activity and carotid wall thickening. Circulation 89:952-954, 1994
27. Castellano M, Muiesan ML, Rizzoni D, Beschi M, Pasini G, Cinelli A, Salvetti M, Porteri E, Bettoni G, Kreutz R, Lindpaintner K, Rosei EA: Angiotensin-converting enzyme I/D polymorphism and arterial wall thickness in a general population: the Vobarno Study. Circulation 91:2721-2724, 1995
28. Hosoi M, Nishizawa Y, Kogawa K, Kawagishi T, Konishi T, Maekawa K, Emoto M, Fukumoto S, Shioi A, Shoji T, Inaba M, Okuno Y, Morii H: Angiotensin-converting enzyme gene polymorphism is associated with carotid arterial wall thickness in non-insulin-dependent diabetic patients. Circulation 94:704-707, 1996
29. Kauma H, Paivansalo M, Savolainen MJ, Rantala AO, Kiema TR, Lilja M, Reunanen A, Kesaniemi YA: Association between angiotensin converting enzyme gene polymorphism and carotid atherosclerosis. J Hypertens 14:1183-1187, 1996
30. Yamasaki Y, Kawamori R, Matsushima H, Nishizawa H, Kodama M, Kajimoto Y, Morishima T, Kamada T: Atherosclerosis in carotid artery of young IDDM patients monitored by ultrasound high-resolution B-mode imaging. Diabetes 43:634-639, 1994
31. Cambien F, Costerousse O, Tiret L, Poirier O, Lecerf L, Gonzalez MF, Evans A, Arveiler D, Cambou JP, Luc G, Rakotovao R, Ducimetiere P, Soubrier F, Alhenc-Gelas F: Plasma level and gene polymorphism of angiotensin-converting enzyme in relation to myocardial infarction. Circulation 90:669-676, 1994
32. Chowdhury TA, Dronsfield MJ, Kumar S, Gough SLC, Gibson SP, Khatoon A, Mac-Donald F, Rowe BR, Dunger DB, Dean JD, Davies SJ, Webber J, Smith PR, Mackin P, Marshall SM, Adu D, Morris PJM, Todd JA, Barnett AH, Boulton AJM, Bain SC: Examination of two genetic polymorphisms within the renin-angiotensin system: no evidence for an association with nephropathy in IDDM. Diabetologia 39:1108-1114, 1996
33. Lindpaintner K, Pfeffer MA, Kreutz R, Stampfer MJ, Grodstein F, LaMotte F, Buring J, Hennekens CH: A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease. N Engl J Med 332:706-711, 1995
34. Marre M, Bernadet P, Gallois Y, Savagner F, Guyene TT, Hallab M, Cambien F, Passa P, Alhenc-Gelas F: Relationships between angiotensin I converting enzyme gene polymorphism, plasma levels, and diabetic retinal and renal complications. Diabetes 43:384-388, 1994
35. Morris BJ, Zee RYL, Schrader AP: Different frequencies of angiotensin-converting enzyme genotypes in older hypertensive individuals. J Clin Invest 94:1085-1089, 1994
36. Schachter F, Faure-Delanef L, Guenot F, Rouger H, Froguel P, Lesueur-Ginot L, Cohen D: Genetic associations with human longevity at the ApoE and ACE loci. Nat Genet 6:29-32, 1994