메뉴 건너뛰기




Volumn 42, Issue 3, 2006, Pages 319-335

Colonic drug delivery. I - The colon as a site for drug delivery;Liberação específica de fármacos para administração no cólon por via oral. I - O cólon como local de liberação de fármacos

Author keywords

Absorption; Colon; Colonic microflora; Colonic pH; Gastrointestinal transit; Inflammatory bowel disease

Indexed keywords

EUDRAGIT; MESALAZINE; PEPTIDASE; PEPTIDE DERIVATIVE; PROTEIN DERIVATIVE;

EID: 33845488123     PISSN: 15169332     EISSN: None     Source Type: Journal    
DOI: 10.1590/s1516-93322006000300003     Document Type: Review
Times cited : (10)

References (77)
  • 3
    • 0028033502 scopus 로고
    • Targeting drugs to the colon: Delivery systems for oral administration
    • London
    • ASHFORD, M.; FELL, J. T. Targeting drugs to the colon: delivery systems for oral administration. J. Drug Targeting, London, v. 2, p. 241-258, 1994.
    • (1994) J. Drug Targeting , vol.2 , pp. 241-258
    • Ashford, M.1    Fell, J.T.2
  • 5
    • 0025310950 scopus 로고
    • The effect of food on gastrointestinal transit (GI) transit of sustained-release ibuprofen tablets as evaluated by gamma scintigraphy
    • Amsterdam
    • BORIN, M. T.; KHARE, S.; BEIHN, R. M.; JAY, M. The effect of food on gastrointestinal transit (GI) transit of sustained-release ibuprofen tablets as evaluated by gamma scintigraphy. Pharma. Res., Amsterdam, v. 7, n.3, p.304-307, 1990.
    • (1990) Pharma. Res. , vol.7 , Issue.3 , pp. 304-307
    • Borin, M.T.1    Khare, S.2    Beihn, R.M.3    Jay, M.4
  • 6
    • 0020576357 scopus 로고
    • Clinical appearance at diagnosis of ulcerative colitis and Crohn's disease in a regional patient group
    • London
    • BOTH, H.; TORP-PEDERSEN, K.; KREINER, S.; HENDRIKSEN, B., V. Clinical appearance at diagnosis of ulcerative colitis and Crohn's disease in a regional patient group. Scand. J. Gastroenterol., London, v. 18, p. 987-991, 1983.
    • (1983) Scand. J. Gastroenterol. , vol.18 , pp. 987-991
    • Both, H.1    Torp-Pedersen, K.2    Kreiner, S.3    Hendriksen, B.V.4
  • 8
    • 0028924730 scopus 로고
    • Comparative gastrointestinal transit of pellets systems of varying density
    • Amsterdam
    • CLARKE, G. M.; NEWTON, J. M.; SHORT, M. B. Comparative gastrointestinal transit of pellets systems of varying density. Int. J. Pharm., Amsterdam, v. 114, p. 1-11, 1995.
    • (1995) Int. J. Pharm. , vol.114 , pp. 1-11
    • Clarke, G.M.1    Newton, J.M.2    Short, M.B.3
  • 9
    • 0027431325 scopus 로고
    • Gastrointestinal transit of pellets of differing size and density
    • Amsterdam
    • CLARKE, G. M.; NEWTON, J. M.; SHORT, M. B. Gastrointestinal transit of pellets of differing size and density. Int. J. Pharm., Amsterdam, v. 100, p. 81-95, 1993.
    • (1993) Int. J. Pharm. , vol.100 , pp. 81-95
    • Clarke, G.M.1    Newton, J.M.2    Short, M.B.3
  • 10
    • 0018954519 scopus 로고
    • Effects of meal size and correction technique on gastric emptying time: Studies with two tracers and opposed detectors
    • London
    • CHRISTIAN, P. E.; MOORE, J. G.; SORENSON, J. A.; COLEMAN, R. E.; WELCH, D. M. Effects of meal size and correction technique on gastric emptying time: studies with two tracers and opposed detectors. J. Nucl. Med., London, v. 21, p. 883-885, 1980.
    • (1980) J. Nucl. Med. , vol.21 , pp. 883-885
    • Christian, P.E.1    Moore, J.G.2    Sorenson, J.A.3    Coleman, R.E.4    Welch, D.M.5
  • 11
    • 0003986775 scopus 로고
    • Year Book Medical Publisher, New York
    • rd Ed, Year Book Medical Publisher, New York, 1971.
    • (1971) rd Ed
    • Davenport, H.W.1
  • 12
    • 0031544302 scopus 로고    scopus 로고
    • Acrylic polymers for colon-specific drug delivery
    • Paris
    • DAVID, A.; YAGEN, B.; SINTOV, A.; RUBINSTEIN, A. Acrylic polymers for colon-specific drug delivery. STP Pharma Sci., Paris, v. 7. n. 6, p. 546-554, 1997.
    • (1997) STP Pharma Sci. , vol.7 , Issue.6 , pp. 546-554
    • David, A.1    Yagen, B.2    Sintov, A.3    Rubinstein, A.4
  • 13
    • 0022538998 scopus 로고
    • Transit of pharmaceutical dosage forms through the small intestine
    • London
    • DAVIS, S. S.; HARDY, J. G.; FARA, J. W. Transit of pharmaceutical dosage forms through the small intestine. Gut, London, v. 27, p. 886-892, 1986.
    • (1986) Gut , vol.27 , pp. 886-892
    • Davis, S.S.1    Hardy, J.G.2    Fara, J.W.3
  • 14
    • 0003122723 scopus 로고
    • Small intestine transit
    • Hardy. J. G.; Davis, S. S.; Wilson, C. G., eds. New York: Ellis Horwood Limited.
    • DAVIS, S. S. Small intestine transit. In: HARDY. J. G.; DAVIS, S. S.; WILSON, C. G., eds. Drug delivery to the gastrointestinal tract. New York: Ellis Horwood Limited. 1989. p.49-61.
    • (1989) Drug Delivery to the Gastrointestinal Tract , pp. 49-61
    • Davis, S.S.1
  • 15
    • 0025042445 scopus 로고
    • The influence of density on the gastrointestinal transit of pellets
    • London
    • DEVEROUX, J. E.; NEWTON, J. M.; SHORT, M. B. The influence of density on the gastrointestinal transit of pellets. J. Pharm. Pharmacol., London, v. 42, p. 500-501, 1990.
    • (1990) J. Pharm. Pharmacol. , vol.42 , pp. 500-501
    • Deveroux, J.E.1    Newton, J.M.2    Short, M.B.3
  • 16
    • 0000888475 scopus 로고
    • Oral route of peptide and protein delivery
    • Lee, V.H.L., ed. New York: Marcel-Dekker
    • DODDA-KASHI, S.; GRASS, G.M.; RUBAS, W. Oral route of peptide and protein delivery. In: LEE, V.H.L., ed. Peptide and protein drug delivery. New York: Marcel-Dekker, 1991. p.691-738.
    • (1991) Peptide and Protein Drug Delivery , pp. 691-738
    • Dodda-Kashi, S.1    Grass, G.M.2    Rubas, W.3
  • 17
    • 0002837057 scopus 로고
    • Anatomical and physiological basis: Physiological factors influencing drug absorption
    • Bieck, P. R., ed. Drugs and the Pharmaceutical Sciences, New York: Marcel-Dekker
    • EDWARDS, C. A. Anatomical and physiological basis: physiological factors influencing drug absorption. In: BIECK, P. R., ed. Colonic drug absorption and metabolism. Drugs and the Pharmaceutical Sciences, New York: Marcel-Dekker, v. 60, 1993. p. 1-28.
    • (1993) Colonic Drug Absorption and Metabolism , vol.60 , pp. 1-28
    • Edwards, C.A.1
  • 18
    • 0024563628 scopus 로고
    • Stress effects on gastrointestinal transit in the rat
    • London
    • ENCK, P.; MERLIN, V.; ERCKENBRECHT, J.F.; WIENBECK, M. Stress effects on gastrointestinal transit in the rat. Gut. London, v. 30, p. 455-459, 1989.
    • (1989) Gut , vol.30 , pp. 455-459
    • Enck, P.1    Merlin, V.2    Erckenbrecht, J.F.3    Wienbeck, M.4
  • 19
    • 0023234298 scopus 로고
    • Increased fecal glycosidases in patients with Crohn's disease
    • London
    • EMBDEN, J.G.H.R.; VAN LIESHOUT, L.M.C. Increased fecal glycosidases in patients with Crohn's disease. Digestion, London, v. 37, p. 43-50, 1987.
    • (1987) Digestion , vol.37 , pp. 43-50
    • Embden, J.G.H.R.1    Van Lieshout, L.M.C.2
  • 20
    • 0023693299 scopus 로고
    • Measurement of gastrointestinal pH profiles in normal ambulant human subjects
    • London
    • EVANS, D. F.; PYE, G.; BRAMLEY, R.; CLARK, A. G.; DYSON, T. J., HARDCASTLE, J. D. Measurement of gastrointestinal pH profiles in normal ambulant human subjects. Gut. London, v. 29, p. 1035-1041, 1988.
    • (1988) Gut. , vol.29 , pp. 1035-1041
    • Evans, D.F.1    Pye, G.2    Bramley, R.3    Clark, A.G.4    Dyson, T.J.5    Hardcastle, J.D.6
  • 21
    • 0041684535 scopus 로고
    • Drug metabolism in the colon wall and lumen
    • Bieck, P. R., ed. Drugs and the Pharmaceutical Sciences, New York: Marcel-Dekker
    • FAIGLE, J. W. Drug Metabolism in the Colon Wall and Lumen. In: BIECK, P. R., ed. Colonic drug absorption and metabolism. Drugs and the Pharmaceutical Sciences, New York: Marcel-Dekker, v. 60, 1993, p. 29-54.
    • (1993) Colonic Drug Absorption and Metabolism , vol.60 , pp. 29-54
    • Faigle, J.W.1
  • 22
    • 0027490263 scopus 로고
    • Very low intraluminal colonic pH in patients with active ulcerative colitis
    • London
    • FALLINGBORG, J.; CHRISTENSEN, L. A.; JACOBSEN, B. A.; RASMUSSEN, S.N. Very low intraluminal colonic pH in patients with active ulcerative colitis. Dig. Dix. Sci., London, v. 38, n. 11, p. 1989-1993, 1993.
    • (1993) Dig. Dix. Sci. , vol.38 , Issue.11 , pp. 1989-1993
    • Fallingborg, J.1    Christensen, L.A.2    Jacobsen, B.A.3    Rasmussen, S.N.4
  • 23
    • 0026608368 scopus 로고
    • Biopharmaceutical comparison of oral multiple-unit and single-unit sustained-release dosage forms
    • Paris
    • FOLLONIER, N.; DOELKER, E. Biopharmaceutical comparison of oral multiple-unit and single-unit sustained-release dosage forms. S.T.P. Pharma Sci., Paris, v. 2, p. 141-158, 1992.
    • (1992) S.T.P. Pharma Sci. , vol.2 , pp. 141-158
    • Follonier, N.1    Doelker, E.2
  • 24
    • 8844286917 scopus 로고    scopus 로고
    • New oral delivery systems for treatment of inflammatory bowel disease
    • FRIEND, D. R. New oral delivery systems for treatment of inflammatory bowel disease. Adv. Drug Deliv. Rev., Amsterdam, v. 57, p. 247-265, 2004.
    • (2004) Adv. Drug Deliv. Rev., Amsterdam , vol.57 , pp. 247-265
    • Friend, D.R.1
  • 26
    • 2442526386 scopus 로고    scopus 로고
    • Pharmaceutical design of a novel colon-target delivery system using two-layer-coated tablets of three different pharmaceutical formulations, supported by clinical evidence in humans
    • Amsterdam
    • GOTO, T.; TANIDA, N.; YOSHINAGA, T.; SATO, S.; BALL, D.J.; WILDING, I.R.; KOBAYASHI, E.; FUJIMURA, A. Pharmaceutical design of a novel colon-target delivery system using two-layer-coated tablets of three different pharmaceutical formulations, supported by clinical evidence in humans. J. Control. Release, Amsterdam, v. 97, p. 31-42, 2004.
    • (2004) J. Control. Release , vol.97 , pp. 31-42
    • Goto, T.1    Tanida, N.2    Yoshinaga, T.3    Sato, S.4    Ball, D.J.5    Wilding, I.R.6    Kobayashi, E.7    Fujimura, A.8
  • 27
    • 0035253622 scopus 로고    scopus 로고
    • A novel pH- and time-based multi-unit potential colonic drug delivery system. II. Optimization of multiple response variables
    • Amsterdam
    • GUPTA, V. K.; ASSMUS, M. W.; BECKERT, T. E.; PRICE, J. C. A novel pH- and time-based multi-unit potential colonic drug delivery system. II. Optimization of multiple response variables. Int. J. Pharm., Amsterdam, v. 213, p. 93-102, 2001.
    • (2001) Int. J. Pharm. , vol.213 , pp. 93-102
    • Gupta, V.K.1    Assmus, M.W.2    Beckert, T.E.3    Price, J.C.4
  • 28
    • 0001861801 scopus 로고
    • Anatomy and physiology of the gastrointestinal tract: Implications for colonic drug delivery
    • Friend, D. R. ed., London, CRC Press
    • HAEBERLIN, B.; FRIEND, D. R. Anatomy and physiology of the gastrointestinal tract: implications for colonic drug delivery. In: FRIEND, D. R. ed. Oral colon-specific drug delivery, London, CRC Press, 1992. p. 1-43.
    • (1992) Oral Colon-Specific Drug Delivery , pp. 1-43
    • Haeberlin, B.1    Friend, D.R.2
  • 29
    • 0001943582 scopus 로고
    • Colonic transit and drug delivery
    • Hardy, J. G.; Davis, S. S.; Wilson, C. G., eds. Ed. New York: Ellis Horwood Limited
    • HARDY, J. G. Colonic Transit and Drug Delivery. In: HARDY, J. G.; DAVIS, S. S.; WILSON, C. G., eds. Drug delivery: to the gastrointestinal tract. Ed. New York: Ellis Horwood Limited. 1989. p.75-81.
    • (1989) Drug Delivery: To the Gastrointestinal Tract , pp. 75-81
    • Hardy, J.G.1
  • 30
    • 0001840594 scopus 로고
    • Scintigraphic tecniques in studying colonic drug absorption
    • Bieck, P. R., ed., Drugs and the Pharmaceutical Sciences. Ed. New York: Marcel-Dekker
    • HARDY, J. G. Scintigraphic Tecniques in Studying Colonic Drug Absorption. In: BIECK, P. R., ed. Colonic drug absorption and metabolism, Drugs and the Pharmaceutical Sciences. Ed. New York: Marcel-Dekker, v. 60, 1993, p. 77-87.
    • (1993) Colonic Drug Absorption and Metabolism , vol.60 , pp. 77-87
    • Hardy, J.G.1
  • 31
    • 0023781542 scopus 로고
    • Gastrointestinal transit of small tablets in patients with ulcerative colitis
    • Amsterdam
    • HARDY, J. G.; DAVIS, S. S.; KHOSLA, R.; ROBERTSON, C. S. Gastrointestinal transit of small tablets in patients with ulcerative colitis. Int. J. Pharm., Amsterdam, v. 48, p. 79-82, 1988.
    • (1988) Int. J. Pharm. , vol.48 , pp. 79-82
    • Hardy, J.G.1    Davis, S.S.2    Khosla, R.3    Robertson, C.S.4
  • 32
    • 0022378338 scopus 로고
    • Drug delivery to the proximal colon
    • London
    • HARDY, J. G.; WILSON, C. G.; WOOD, E. Drug delivery to the proximal colon. J. Pharm. Pharmacol., London, v. 37, p. 874-877, 1985.
    • (1985) J. Pharm. Pharmacol. , vol.37 , pp. 874-877
    • Hardy, J.G.1    Wilson, C.G.2    Wood, E.3
  • 33
    • 0032995635 scopus 로고    scopus 로고
    • A pH-dependent colon targeted oral drug delivery system using methacrylic acid copolymers I. Manipulation of drug release using Eudragit® L100-55 and Eudragit® S100 combinations
    • Amsterdam
    • KHAN, M. Z. I.; PREBEG Z.; KURJAKOVIC, N. A pH-dependent colon targeted oral drug delivery system using methacrylic acid copolymers I. Manipulation of drug release using Eudragit® L100-55 and Eudragit® S100 combinations. J. Control. Release, Amsterdam, v. 58, p. 215-222, 1999.
    • (1999) J. Control. Release , vol.58 , pp. 215-222
    • Khan, M.Z.I.1    Prebeg, Z.2    Kurjakovic, N.3
  • 34
    • 8844258136 scopus 로고    scopus 로고
    • Topical delivery of therapeutics agents in the treatment of inflammatory bowel disease
    • Amsterdam
    • KLOTZ, U.; SCHWAB, M. Topical delivery of therapeutics agents in the treatment of inflammatory bowel disease. Adv. Drug Deliv. Rev., Amsterdam, v. 57, p. 267-279, 2004.
    • (2004) Adv. Drug Deliv. Rev. , vol.57 , pp. 267-279
    • Klotz, U.1    Schwab, M.2
  • 35
    • 0024980030 scopus 로고
    • The effect of food on the movement of pellets in the gastrointestinal tract
    • Ed., Amsterdam
    • KYROUDIS, A.; MARKANTONIS, S. L.; BECKETT, A. H. The effect of food on the movement of pellets in the gastrointestinal tract. Pharm. Weekbl. Scien. Ed., Amsterdam, v. 11, p. 44-49, 1988.
    • (1988) Pharm. Weekbl. Scien. , vol.11 , pp. 44-49
    • Kyroudis, A.1    Markantonis, S.L.2    Beckett, A.H.3
  • 36
    • 0025243656 scopus 로고
    • Disposition of 5-aminosalicylic acid by olsalazine and three mesalazine preparations in patients with ulcerative colitis: Comparison of intraluminal colonic concentrations, serum values, and urinary excretion
    • London
    • LAURSEN, L. S.; STOKHOLM, M.; BUKHAVE, K.; RASK-MADSEN, J.; LAURITSEN, K. Disposition of 5-aminosalicylic acid by olsalazine and three mesalazine preparations in patients with ulcerative colitis: comparison of intraluminal colonic concentrations, serum values, and urinary excretion. Gut, London, v. 31, p. 1271-1276, 1990.
    • (1990) Gut , vol.31 , pp. 1271-1276
    • Laursen, L.S.1    Stokholm, M.2    Bukhave, K.3    Rask-Madsen, J.4    Lauritsen, K.5
  • 37
    • 0002102983 scopus 로고
    • Kinetic perspectives in colon drug delivery
    • Friend, D. R. ed., London, CRC Press
    • MACLEOD, A. D.; TOZER, T. N. Kinetic perspectives in colon drug delivery. In: FRIEND, D. R. ed. Oral colon-specific drug delivery, London, CRC Press, 1992. p. 85-114.
    • (1992) Oral Colon-Specific Drug Delivery , pp. 85-114
    • Macleod, A.D.1    Tozer, T.N.2
  • 38
    • 0023616435 scopus 로고
    • Effect of polymer coating on fecal recovery of ingested 5-amino salicylic acid in patients with ulcerative colitis
    • London
    • MARDINI, H. A. L.; LINDSAY, D. C.; DEIGHTON, C. M.; RECORD, C. O. Effect of polymer coating on fecal recovery of ingested 5-amino salicylic acid in patients with ulcerative colitis. Gut, London, v. 28, p. 1084-1089, 1987.
    • (1987) Gut , vol.28 , pp. 1084-1089
    • Mardini, H.A.1    Lindsay, D.C.2    Deighton, C.M.3    Record, C.O.4
  • 40
    • 0002707840 scopus 로고
    • Drug absorption in the colon: A critical review
    • Friend, D. R. ed. London: CRC Press
    • MRSNY, R. J., Drug absorption in the colon: a critical review. In: FRIEND, D. R. ed. Oral-colon specific drug delivery, London: CRC Press, 1992a. p. 45-84.
    • (1992) Oral-Colon Specific Drug Delivery , pp. 45-84
    • Mrsny, R.J.1
  • 41
    • 0026722203 scopus 로고
    • The colon as a site for drug delivery
    • Amsterdam
    • MRSNY, R. J. The colon as a site for drug delivery. J. Control. Release, Amsterdam, v. 22, p. 15-34, 1992b.
    • (1992) J. Control. Release , vol.22 , pp. 15-34
    • Mrsny, R.J.1
  • 42
    • 0035084176 scopus 로고    scopus 로고
    • Intestinal luminal pH in inflammatory bowel disease: Possible determinants and implications for therapy with aminosalicylates and other drugs
    • London
    • NUGENT, S. G.; RAMPTON, D. S.; EVANS, D. F. Intestinal luminal pH in inflammatory bowel disease: possible determinants and implications for therapy with aminosalicylates and other drugs. Gut, London, v. 48, p. 571-577, 2001.
    • (2001) Gut , vol.48 , pp. 571-577
    • Nugent, S.G.1    Rampton, D.S.2    Evans, D.F.3
  • 43
    • 0023089470 scopus 로고
    • The influence of food on the gastric emptying of multiparticulate dosage forms
    • Amsterdam
    • O'REILLY, S.; WILSON, C. G.; HARDY, J. G.; The influence of food on the gastric emptying of multiparticulate dosage forms. Int. J. Pharm., Amsterdam, v. 34, p. 213-216, 1987.
    • (1987) Int. J. Pharm. , vol.34 , pp. 213-216
    • O'Reilly, S.1    Wilson, C.G.2    Hardy, J.G.3
  • 44
    • 2342442430 scopus 로고    scopus 로고
    • Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease
    • London
    • OTT, S. J.; MUSFELDT, M.; WENDEROTH, D.F.; HAMPE, J.; BRANT, O.; FÖLSH, U. R.; TIMMIS, K. N.; SCHREIBER, S. Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease. Gut, London, v. 53, p. 685-693, 2003.
    • (2003) Gut , vol.53 , pp. 685-693
    • Ott, S.J.1    Musfeldt, M.2    Wenderoth, D.F.3    Hampe, J.4    Brant, O.5    Fölsh, U.R.6    Timmis, K.N.7    Schreiber, S.8
  • 45
    • 0023930636 scopus 로고
    • Motility of the ileocecal junction
    • London
    • PHILLIPS, S. F.; QUIGLEY, E.M.M.; KUMAR, D.; KAMATH, P.S. Motility of the ileocecal junction. Gut, London, v.29, p.390-406, 1988.
    • (1988) Gut , vol.29 , pp. 390-406
    • Phillips, S.F.1    Quigley, E.M.M.2    Kumar, D.3    Kamath, P.S.4
  • 46
    • 0027302312 scopus 로고
    • The effect of meal composition on the gastro colonic response: Implications for drug delivery to the colon
    • Stuttgart
    • PRICE, J. M. C.; DAVIS, S. S.; SPARROW, R. A.; WILDING, I. R. The effect of meal composition on the gastro colonic response: implications for drug delivery to the colon. Pharm. Res., Stuttgart, v. 10, n. 5, p. 722-726, 1993.
    • (1993) Pharm. Res. , vol.10 , Issue.5 , pp. 722-726
    • Price, J.M.C.1    Davis, S.S.2    Sparrow, R.A.3    Wilding, I.R.4
  • 47
    • 0005624004 scopus 로고
    • Effect of dietary fibre on colonic pH in healthy volunteers
    • London
    • PYE, G.; CROMPTON, J.; EVANS, D. Effect of dietary fibre on colonic pH in healthy volunteers. Gut, London, v. 28: A:1366, 1987.
    • (1987) Gut , vol.28 , pp. 1366
    • Pye, G.1    Crompton, J.2    Evans, D.3
  • 49
    • 0008740374 scopus 로고
    • Non-invasive methods for measuring gastrointestinal transit
    • Hardy, J. G.; Davis, S. S.; Wilson, C. G., ed. New York: Ellis Horwood Limited
    • READ, N. W.; MANGNALL, Y. F.; TOMLIN, J.; BROWN, N. Non-Invasive Methods for Measuring Gastrointestinal Transit. In: HARDY, J. G.; DAVIS, S. S.; WILSON, C. G., ed. Drug delivery to the gastrointestinal tract. New York: Ellis Horwood Limited. 1989, p.9-25.
    • (1989) Drug Delivery to the Gastrointestinal Tract , pp. 9-25
    • Read, N.W.1    Mangnall, Y.F.2    Tomlin, J.3    Brown, N.4
  • 50
    • 33845490769 scopus 로고
    • Influence of disease on colonic drug absorption
    • Bieck, P. R., (Ed,). Drugs and the Pharmaceutical Sciences, New York: Marcel-Dekker
    • RILEY, S.A. Influence of Disease on Colonic Drug Absorption. In: BIECK, P. R., (Ed,). Colonic drug absorption and metabolism. Drugs and the Pharmaceutical Sciences, New York: Marcel-Dekker, v. 60, 1993. p. 177-195.
    • (1993) Colonic Drug Absorption and Metabolism , vol.60 , pp. 177-195
    • Riley, S.A.1
  • 51
    • 0018855591 scopus 로고
    • The colonic epithelium in ulcerative colitis: An energy deficiency disease?
    • London
    • ROEDIGER, W. E. The colonic epithelium in ulcerative colitis: an energy deficiency disease? Lancet, London, v. 2, p. 712-715, 1980.
    • (1980) Lancet , vol.2 , pp. 712-715
    • Roediger, W.E.1
  • 52
    • 0029953050 scopus 로고    scopus 로고
    • Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery
    • Amsterdam
    • ROUGE, N.; BURI, P.; DOELKER, E. Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery. Int. J. Pharm., Amsterdam v. 136, p. 117-139, 1996.
    • (1996) Int. J. Pharm. , vol.136 , pp. 117-139
    • Rouge, N.1    Buri, P.2    Doelker, E.3
  • 53
    • 0344809638 scopus 로고
    • Biodegradable polymeric matrices with the potential specificity to the large intestine
    • Friend, D. R. ed., London, CRC Press
    • RUBINSTEIN, A.; SINTOV, A. Biodegradable polymeric matrices with the potential specificity to the large intestine. In: FRIEND, D. R. ed. Oral colon-specific drug delivery, London, CRC Press, 1992. p. 233-257.
    • (1992) Oral Colon-Specific Drug Delivery , pp. 233-257
    • Rubinstein, A.1    Sintov, A.2
  • 54
    • 0031046957 scopus 로고    scopus 로고
    • The rationale for peptide drug delivery to the colon and the potential of polymeric carriers as effective tools
    • Amsterdam
    • RUBINSTEIN, A.; TIROSH, B.; BALUOM, M.; NASSAR, T.; DAVID, A.; RADAI, R.; GLIKO-KABIR, I.; FRIEDMAN, M. The rationale for peptide drug delivery to the colon and the potential of polymeric carriers as effective tools. J. Control. Release, Amsterdam, v.46, p. 59-73, 1997.
    • (1997) J. Control. Release , vol.46 , pp. 59-73
    • Rubinstein, A.1    Tirosh, B.2    Baluom, M.3    Nassar, T.4    David, A.5    Radai, R.6    Gliko-Kabir, I.7    Friedman, M.8
  • 55
    • 0006455431 scopus 로고
    • Oral colon-specific drug delivery with emphasis in insulin
    • Friend, D. R. ed., London, CRC Press
    • SAFFRAN, M. Oral colon-specific drug delivery with emphasis in insulin. In: FRIEND. D. R. ed. Oral colon-specific drug delivery, London, CRC Press, 1992. p. 115-142.
    • (1992) Oral Colon-Specific Drug Delivery , pp. 115-142
    • Saffran, M.1
  • 56
    • 0035907163 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of an oral system for time and/or site-specific drug delivery
    • Amsterdam
    • SANGALLI, M. E.; MARONI, A.; ZEMA, L.; GIORDANO, F.; GAZZANIGA, A. In vitro and in vivo evaluation of an oral system for time and/or site-specific drug delivery. J. Control. Release, Amsterdam, v. 73, p. 103-110, 2001.
    • (2001) J. Control. Release , vol.73 , pp. 103-110
    • Sangalli, M.E.1    Maroni, A.2    Zema, L.3    Giordano, F.4    Gazzaniga, A.5
  • 57
    • 0031032409 scopus 로고    scopus 로고
    • Improved localizing method of radiopill in measurement of entire gastrointestinal pH profiles: Colonic luminal pH in normal subjects and in patients with Cohn's disease
    • London
    • SASAKI, Y.; HADA, R.; NAKAJIMA, H.; FUKUDA, S.; MUNAKATA, A. Improved localizing method of radiopill in measurement of entire gastrointestinal pH profiles: Colonic luminal pH in normal subjects and in patients with Cohn's disease. Am. J. Gastroenterology. London, v. 92, p. 114-118, 1997.
    • (1997) Am. J. Gastroenterology , vol.92 , pp. 114-118
    • Sasaki, Y.1    Hada, R.2    Nakajima, H.3    Fukuda, S.4    Munakata, A.5
  • 58
    • 3242740076 scopus 로고    scopus 로고
    • Time-release compression-coated core tablet containing nifedipine for chronopharmacotherapy
    • Amsterdam
    • SAWADA, T.; KONDO, H.; NAKASHIMA, H.; SAKO, K.; HAYASHI, M. Time-release compression-coated core tablet containing nifedipine for chronopharmacotherapy. Int. J. Pharm., Amsterdam, v. 280, p. 103-111, 2004.
    • (2004) Int. J. Pharm. , vol.280 , pp. 103-111
    • Sawada, T.1    Kondo, H.2    Nakashima, H.3    Sako, K.4    Hayashi, M.5
  • 59
    • 0023521441 scopus 로고
    • Coated 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis
    • London
    • SCHROEDER, K. W.; TREMAINE, W. J.; ILSTRUP, D. M. Coated 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. New Eng. J. Med., London, v. 317, p. 1625-1629, 1987
    • (1987) New Eng. J. Med. , vol.317 , pp. 1625-1629
    • Schroeder, K.W.1    Tremaine, W.J.2    Ilstrup, D.M.3
  • 60
    • 8844272702 scopus 로고    scopus 로고
    • Regulation of intestinal epithelial function: A link between opportunities for macromolecular drug delivery and inflammatory bowel disease
    • Amsterdam
    • SICCARDI, D.; TURNER, J. R.; MRSNY, R. Regulation of intestinal epithelial function: a link between opportunities for macromolecular drug delivery and inflammatory bowel disease. Adv. Drug Deliv. Rev., Amsterdam, v.57, p. 219-235, 2005.
    • (2005) Adv. Drug Deliv. Rev. , vol.57 , pp. 219-235
    • Siccardi, D.1    Turner, J.R.2    Mrsny, R.3
  • 61
    • 0037027874 scopus 로고    scopus 로고
    • Binders for colon specific drug delivery: An in vitro evaluation
    • Amsterdam
    • SINHA, S. R.; KUMRIA, R. Binders for colon specific drug delivery: an in vitro evaluation. Int. J. Pharm., Amsterdam, v. 249, p. 23-31, 2002.
    • (2002) Int. J. Pharm. , vol.249 , pp. 23-31
    • Sinha, S.R.1    Kumria, R.2
  • 62
    • 0023106493 scopus 로고
    • Emptying of terminal ileum in intact humans - Influence of meal residue and ileum motility
    • London
    • SPILLER, R. C.; BROWN, M.L. AND PHILLIPS, S. F. Emptying of terminal ileum in intact humans- Influence of meal residue and ileum motility. Gastroenterology, London, v. 92, p. 724-779, 1987.
    • (1987) Gastroenterology , vol.92 , pp. 724-779
    • Spiller, R.C.1    Brown, M.L.2    Phillips, S.F.3
  • 63
    • 0028117637 scopus 로고
    • The in vivo behaviour of a colonic delivery system: A pilot study in man
    • Amsterdam
    • STEED, K. P.; HOOPER, G.; VENTURA, P.; MUSA, R.; WILDING, I. R. The in vivo behaviour of a colonic delivery system: a pilot study in man. Int. J. Pharm., Amsterdam, v. 112, p. 199-206, 1994.
    • (1994) Int. J. Pharm. , vol.112 , pp. 199-206
    • Steed, K.P.1    Hooper, G.2    Ventura, P.3    Musa, R.4    Wilding, I.R.5
  • 65
    • 0027073283 scopus 로고
    • Gastric emptying rate of drug preparations. III. Effects of size of enteric micro-capsules with mean diameters ranging from 0.1 to 1.1 mm in man
    • London
    • SUGITO, K.; OGATA, H.; GOTO, H.; KANIWA, N.; TAKAHATA, H.; SAMEJIMA, M. Gastric emptying rate of drug preparations. III. Effects of size of enteric micro-capsules with mean diameters ranging from 0.1 to 1.1 mm in man. Chem. Pharm. Bull., London, v. 40, p. 3343-3345, 1992.
    • (1992) Chem. Pharm. Bull. , vol.40 , pp. 3343-3345
    • Sugito, K.1    Ogata, H.2    Goto, H.3    Kaniwa, N.4    Takahata, H.5    Samejima, M.6
  • 66
    • 0141907178 scopus 로고
    • Models for intestinal permeability to drugs
    • Hardy, J. G.; Davis, S. S.; Wilson, C. G., ed. New York: Ellis Horwood Limited
    • TAYLOR, D. C.; LYNCH, J.; LEAHY, D. E. Models for intestinal permeability to drugs. In: HARDY, J. G.; DAVIS, S. S.; WILSON, C. G., ed. Drug delivery to the gastrointestinal tract. New York: Ellis Horwood Limited. 1989. p. 133-146.
    • (1989) Drug Delivery to the Gastrointestinal Tract , pp. 133-146
    • Taylor, D.C.1    Lynch, J.2    Leahy, D.E.3
  • 67
    • 0023743080 scopus 로고
    • Enhancement of colonic drug absorption by the paracellular permeation route
    • Amsterdam
    • TOMITA, M.; SHIGA, M.; HAYASHI, M.; AWAZU, S. Enhancement of colonic drug absorption by the paracellular permeation route. Pharm. Res., Amsterdam, v. 5, n. 6, p. 341-346, 1988.
    • (1988) Pharm. Res. , vol.5 , Issue.6 , pp. 341-346
    • Tomita, M.1    Shiga, M.2    Hayashi, M.3    Awazu, S.4
  • 68
    • 0033034920 scopus 로고    scopus 로고
    • Gastrointestinal transit of pellets in rats: Effect of size and density
    • Amsterdam
    • TULEO, C.; ANDRIEUX, C.; BOY, P.; CHAUMEIL, P. C. Gastrointestinal transit of pellets in rats: effect of size and density, Int. J. Pharm., Amsterdam, v. 180, p. 123-131, 1999.
    • (1999) Int. J. Pharm. , vol.180 , pp. 123-131
    • Tuleo, C.1    Andrieux, C.2    Boy, P.3    Chaumeil, P.C.4
  • 70
    • 0043028154 scopus 로고    scopus 로고
    • Comparative in vitro permeability of human vaginal, small intestinal and colonic mucosa
    • VAN DER BIJL, P.; VAN EYK, A.D.; Comparative in vitro permeability of human vaginal, small intestinal and colonic mucosa, Int. J. Pharm. Amsterdam, v.261, p. 147-152, 2003.
    • (2003) Int. J. Pharm. Amsterdam , vol.261 , pp. 147-152
    • Van Der Bijl, P.1    Van Eyk, A.D.2
  • 71
    • 0029076388 scopus 로고
    • Oral-colon-specific drug delivery: A review
    • London
    • VAN DER MOOTER, G.; KINGET, R. Oral-colon-specific drug delivery: a review, Drug delivery, London, v. 2, p. 81-93, 1995.
    • (1995) Drug Delivery , vol.2 , pp. 81-93
    • Van Der Mooter, G.1    Kinget, R.2
  • 73
    • 0030931837 scopus 로고    scopus 로고
    • Colonic drug delivery
    • London
    • WATTS, P. J.; ILLUM, L. Colonic drug delivery. Drug Dev. Ind. Pharm., London, v. 23, p. 893-913, 1997.
    • (1997) Drug Dev. Ind. Pharm. , vol.23 , pp. 893-913
    • Watts, P.J.1    Illum, L.2
  • 74
    • 0028829981 scopus 로고
    • Scintigraphic evaluation of colonic delivery systems
    • Paris
    • WILDING I. R. Scintigraphic evaluation of colonic delivery systems. S.T.P. Pharma Sci., Paris, v.5, n. 1, p. 13-18, 1995.
    • (1995) S.T.P. Pharma Sci. , vol.5 , Issue.1 , pp. 13-18
    • Wilding, I.R.1
  • 76
    • 0026702404 scopus 로고
    • Decreased fecal exoglycosidase activities identify a subset of patients with active Crohn's disease
    • London
    • YAMNI, J.; MIZON, C.; CAPON, C.; COLOMBEL, J.F.; FOURNET, B.; CORTOT, A.; MIZON, J. Decreased fecal exoglycosidase activities identify a subset of patients with active Crohn's disease. Digestion, London, v. 83, p. 409-415, 1992.
    • (1992) Digestion , vol.83 , pp. 409-415
    • Yamni, J.1    Mizon, C.2    Capon, C.3    Colombel, J.F.4    Fournet, B.5    Cortot, A.6    Mizon, J.7
  • 77
    • 0037139415 scopus 로고    scopus 로고
    • Colon-specific drug delivery: New approaches and in vitro/in vivo evaluation
    • Amsterdam
    • YANG, L.; CHU, J. S.; FIX, J. A.; Colon-specific drug delivery: new approaches and in vitro/in vivo evaluation, Int. J. Pharm., Amsterdam, v. 235, p. 1-15, 2002.
    • (2002) Int. J. Pharm. , vol.235 , pp. 1-15
    • Yang, L.1    Chu, J.S.2    Fix, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.