Pharmaceutical design of a novel colon-targeted delivery system using two-layer-coated tablets of three different pharmaceutical formulations, supported by clinical evidence in humans

Journal of Controlled Release

Volumn 97, Issue 1, 2004, Pages 31-42

  Goto, Takeshi ^a,b   Tanida, Norifumi ^b   Yoshinaga, Takaaki ^b   Sato, Shuji ^b   Ball, D J ^c   Wilding, I R ^c   Kobayashi, Eiji ^a   Fujimura, Akio ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b HISAMITSU PHARMACEUTICAL CO INC   (Japan)

^c PHARMACEUTICAL PROFILES LTD   (United Kingdom)

Author keywords

Colon targeted delivery; Disintegration; Gamma scintigraphy; Samarium; Two layer coated tablets

Indexed keywords

DIGESTIVE SYSTEM; DISEASES; PH EFFECTS; POLYPEPTIDES;

DRUG DELIVERY; HUMAN COLON; ORAL PREPARATIONS;

DRUG PRODUCTS;

BUFFER; CITRIC ACID; EXCIPIENT; HYDROXYPROPYLCELLULOSE; LACTOSE; MAGNESIUM STEARATE; MICROCRYSTALLINE CELLULOSE; PEPTIDE DERIVATIVE; SAMARIUM;

ADULT; ARTICLE; CLINICAL TRIAL; COLON DISEASE; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG FORMULATION; DRUG TARGETING; FEMALE; GASTROINTESTINAL TRACT; HUMAN; HUMAN EXPERIMENT; MALE; METHODOLOGY; NORMAL HUMAN; PH; PHARMACEUTICAL ENGINEERING; PRIORITY JOURNAL; SCINTIANGIOGRAPHY; SMALL INTESTINE; STOMACH; TABLET DISINTEGRATION; TABLET DISINTEGRATION TIME; TABLET FORMULATION;

ADULT; CHEMISTRY, PHARMACEUTICAL; COLON; CROSS-OVER STUDIES; DRUG DELIVERY SYSTEMS; DRUG DESIGN; FEMALE; HUMANS; INTESTINAL ABSORPTION; MALE; MIDDLE AGED; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; TABLETS, ENTERIC-COATED;

EID: 2442526386     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.02.023     Document Type: Article

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